Extract
Gastro-oesophageal reflux disease (GORD) and obesity are associated with frequent exacerbations and poor quality of life in people living with asthma. Multiple mechanisms have been proposed for the effect of obesity, including modification of inflammation affecting epithelial cell proliferation and wound repair, while the role of GORD is poorly understood and proton pump inhibitors (PPIs) are of variable efficacy. GORD might exert a deleterious effect by inducing vagal reflex, neuroinflammation and directly triggering airway inflammation (via microaspiration). Studies of reflux in animal models and human bronchial epithelial cell culture show varying impact on inflammation and airway remodelling. We have recently demonstrated changes in the sputum proteome in severe asthmatics with GORD, providing supportive evidence for gastric secretions exerting a direct effect on the airways [1]. The epithelium plays a key role in asthma, so in this study, we speculated that severe asthma in obese patients with GORD would be associated with epithelial dysfunction. Because GORD is treated with PPIs, drugs associated with risk of pneumonia and exacerbations of chronic obstructive pulmonary disease (COPD) and cystic fibrosis, the impact of PPIs was also assessed.
Abstract
Stratification of severe asthma on the basis of bronchial epithelial gene expression identified a subset whose endotype is defined by marked epithelial dysregulation associated with obesity, gastro-oesophageal reflux and proton pump inhibitors http://bit.ly/2EeKv23
Acknowledgements
J-M. Perotin is the recipient of a European Respiratory Society Long-Term Fellowship (LTRF 2017) and received additional funding to support her research in Southampton, UK, from the Association Régionale pour l'Aide aux Insuffisants Respiratoires de Champagne-Ardenne, Association Nationale de Formation Continue en Allergologie, Association des Allergologues de Champagne-Ardenne and Association des Pneumologues de Champagne-Ardenne. This funding is gratefully acknowledged.
Footnotes
The U-BIOPRED consortium wishes to acknowledge the help and expertise of the following individuals and groups without whom the study would not have been possible: I.M. Adcock, National Heart and Lung Institute, Imperial College, London, UK; H. Ahmed, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; C. Auffray, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; P. Bakke, Dept of Clinical Science, University of Bergen, Bergen, Norway; A.T. Banssal, Acclarogen Ltd, St John's Innovation Centre, Cambridge, UK; F. Baribaud, Janssen R&D, USA; S. Bates, Respiratory Therapeutic Unit, GSK, London, UK; E.H. Bel, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; J. Bigler, previously Amgen Inc.; H. Bisgaard, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; M.J. Boedigheimer, Amgen Inc., Thousand Oaks, USA; K. Bønnelykke, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; J. Brandsma, University of Southampton, Southampton, UK; P. Brinkman, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; E. Bucchioni, Chiesi Pharmaceuticals SPA, Parma, Italy; D. Burg, Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton, UK; A. Bush, National Heart and Lung Institute, Imperial College, London, UK; Royal Brompton and Harefield NHS trust, UK; M. Caruso, Dept Clinical and Experimental Medicine, University of Catania, Catania, Italy; A. Chaiboonchoe, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; P. Chanez, Assistance publique des Hôpitaux de Marseille - Clinique des bronches, allergies et sommeil, Aix Marseille Université, Marseille, France; K.F. Chung, National Heart and Lung Institute, Imperial College, London, UK; C.H. Compton, Respiratory Therapeutic Unit, GSK, London, UK; J. Corfield, Areteva R&D, Nottingham, UK; A. D'Amico, University of Rome “Tor Vergata”, Rome Italy; S.E. Dahlen, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; B. De Meulder, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; R. Djukanovic, NIHR Southampton Respiratory Biomedical Research Unit and Clinical and Experimental Sciences, Southampton, UK; V.J. Erpenbeck, Translational Medicine, Respiratory Profiling, Novartis Institutes for Biomedical Research, Basel, Switzerland; D. Erzen, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; K. Fichtner, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; N. Fitch, BioSci Consulting, Maasmechelen, Belgium; L.J. Fleming, National Heart and Lung Institute, Imperial College, London, UK; Royal Brompton and Harefield NHS trust, UK; E. Formaggio, previously CROMSOURCE, Verona, Italy; S.J. Fowler, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; U. Frey, University Children's Hospital, Basel, Switzerland; M. Gahlemann, Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland; T. Geiser, Dept of Respiratory Medicine, University Hospital Bern, Switzerland; Y. Guo, Data Science Institute, Imperial College, London, UK; S. Hashimoto, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; J. Haughney, International Primary Care Respiratory Group, Aberdeen, UK; G. Hedlin, Dept Women's and Children's Health & Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; P.W. Hekking, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; T. Higenbottam, Allergy Therapeutics, West Sussex, UK; J.M. Hohlfeld, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; C. Holweg, Respiratory and Allergy Diseases, Genentech, San Francisco, USA; I. Horváth, Semmelweis University, Budapest, Hungary; P. Howarth, NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK; A.J. James, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; R. Knowles, Arachos Pharma, Stevenge, UK; A.J. Knox, Respiratory Research Unit, University of Nottingham, Nottingham, UK; N. Krug, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; D. Lefaudeux, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; M.J. Loza, Janssen R&D, USA; R. Lutter, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; A. Manta, Roche Diagnostics GmbH, Mannheim, Germany; S. Masefield, European Lung Foundation, Sheffield, UK; J.G. Matthews, Respiratory and Allergy Diseases, Genentech, San Francisco, USA; A. Mazein, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; A. Meiser, Data Science Institute, Imperial College, London, UK; R.J.M. Middelveld, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; M. Miralpeix, Almirall, Barcelona, Spain; P. Montuschi, Università Cattolica del Sacro Cuore, Milan, Italy; N. Mores, Università Cattolica del Sacro Cuore, Milan, Italy; C.S. Murray, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; J. Musial, Dept of Medicine, Jagiellonian University Medical College, Krakow, Poland; D. Myles, Respiratory Therapeutic Unit, GSK, London, UK; L. Pahus, Assistance publique des Hôpitaux de Marseille, Clinique des bronches, allergies et sommeil, Espace Éthique Méditerranéen, Aix-Marseille Université, Marseille, France; I. Pandis, Data Science Institute, Imperial College, London, UK; S. Pavlidis, National Heart and Lung Institute, Imperial College, London, UK; P. Powell, European Lung Foundation, Sheffield, UK; G. Praticò, CROMSOURCE, Verona, Italy; M. Puig Valls, CROMSOURCE, Barcelona, Spain; N. Rao, Janssen R&D, USA; J. Riley, Respiratory Therapeutic Unit, GSK, London, UK; A. Roberts, Asthma UK, London, UK; G. Roberts, NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK; A. Rowe, Janssen R&D, UK; T. Sandström, Dept of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; W. Seibold, Boehringer Ingelheim Pharma GmbH, Biberach, Germany; A. Selby, NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK; D.E. Shaw, Respiratory Research Unit, University of Nottingham, UK; R. Sigmund, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; F. Singer, University Children's Hospital, Zurich, Switzerland; P.J. Skipp, Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton, UK; A.R. Sousa, Respiratory Therapeutic Unit, GSK, London, UK; P.J. Sterk, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; K. Sun, Data Science Institute, Imperial College, London, UK; B. Thornton, MSD, USA; W.M. van Aalderen, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; M. van Geest, AstraZeneca, Mölndal, Sweden; J. Vestbo, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; N.H. Vissing, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; A.H. Wagener, Academic Medical Center Amsterdam, Amsterdam, The Netherlands; S.S. Wagers, BioSci Consulting, Maasmechelen, Belgium; Z. Weiszhart, Semmelweis University, Budapest, Hungary; C.E. Wheelock, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; S.J. Wilson, Histochemistry Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK. Additional contributors: Antonios Aliprantis, Merck Research Laboratories, Boston, USA; David Allen, North West Severe Asthma Network, Pennine Acute Hospital NHS Trust, UK; Kjell Alving, Dept Women's & Children's Health, Uppsala University, Uppsala, Sweden; P. Badorrek, Fraunhofer ITEM, Hannover, Germany; David Balgoma, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; S. Ballereau, European institute for Systems Biology and Medicine, University of Lyon, France; Clair Barber, NIHR Southampton Respiratory Biomedical Research Unit and Clinical and Experimental Sciences, Southampton, UK; Manohara Kanangana Batuwitage, Data Science Institute, Imperial College, London, UK; An Bautmans, MSD, Brussels, Belgium; A. Bedding, Roche Diagnostics GmbH, Mannheim, Germany; A.F. Behndig, Umeå University, Umea, Sweden; Jorge Beleta, Almirall S.A., Barcelona, Spain; A. Berglind, MSD, Brussels, Belgium; A. Berton, AstraZeneca, Mölndal, Sweden; G. Bochenek, II Dept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland; A. Braun, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; D. Campagna, Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy; L. Carayannopoulos, previously at MSD, USA; C. Casaulta, University Children's Hospital of Bern, Switzerland; Romanas Chaleckis, Centre of Allergy Research, Karolinska Institutet, Stockholm, Sweden; B. Dahlén, Karolinska University Hospital & Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; T. Davison, Janssen R&D, USA; J. De Alba, Almirall S.A., Barcelona, Spain; I. De Lepeleire, MSD, Brussels, Belgium; T. Dekker, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; I. Delin, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; P. Dennison, NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, NIHR-Wellcome Trust Clinical Research Facility, Faculty of Medicine, University of Southampton, Southampton, UK; A. Dijkhuis, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; P. Dodson, AstraZeneca, Mölndal, Sweden; Aleksandra Draper, BioSci Consulting, Maasmechelen, Belgium; K. Dyson, CROMSOURCE, Stirling, UK; J. Edwards, Asthma UK, London, UK; L. El Hadjam, European Institute for Systems Biology and Medicine, University of Lyon, France; R. Emma, Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy; M. Ericsson, Karolinska University Hospital, Stockholm, Sweden; C. Faulenbach, Fraunhofer ITEM, Hannover, Germany; Breda Flood, European Federation of Allergy and Airways Diseases Patient's Associations, Brussels, Belgium; G. Galffy, Semmelweis University, Budapest, Hungary; H. Gallart, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; D. Garissi, Global Head Clinical Research Division, CROMSOURCE, Italy; J. Gent, Royal Brompton and Harefield NHS Foundation Trust, London, UK; M. Gerhardsson de Verdier, AstraZeneca; Mölndal, Sweden; D. Gibeon, National Heart and Lung Institute, Imperial College, London, UK; Cristina Gomez, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; K. Gove, NIHR Southampton Respiratory Biomedical Research Unit and Clinical and Experimental Sciences, Southampton, UK; Neil Gozzard, UCB, Slough, UK; E. Guillmant-Farry, Royal Brompton Hospital, London, UK; E. Henriksson, Karolinska University Hospital & Karolinska Institutet, Stockholm, Sweden; L. Hewitt, NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK; U. Hoda, Imperial College, London, UK; Richard Hu, Amgen Inc. Thousand Oaks, USA; S. Hu, National Heart and Lung Institute, Imperial College, London, UK; X. Hu, Amgen Inc., Thousand Oaks, USA; E. Jeyasingham, UK Clinical Operations, GSK, Stockley Park, UK; K. Johnson, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and repair, University Hospital of South Manchester, NHS Foundation Trust, Manchester, UK; N. Jullian, European Institute for Systems Biology and Medicine, University of Lyon, France; J. Kamphuis, Longfonds, Amersfoort, The Netherlands; E.J. Kennington, Asthma UK, London, UK; D. Kerry, CromSource, Stirling, UK; G. Kerry, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University Hospital of South Manchester, NHS Foundation Trust, Manchester, UK; M. Klüglich, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; H. Knobel, Philips Research Laboratories, Eindhoven, The Netherlands; Johan Kolmert, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; J.R. Konradsen, Dept Women's and Children's Health & Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; M. Kots, Chiesi Pharmaceuticals, SPA, Parma, Italy; Kosmas Kretsos, UCB, Slough, UK; L. Krueger, University Children's Hospital Bern, Switzerland; S. Kuo, National Heart and Lung Institute, Imperial College, London, UK; M. Kupczyk, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; B. Lambrecht, University of Gent, Gent, Belgium; A-S. Lantz, Karolinska University Hospital & Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Christopher Larminie, GSK, London, UK; L.X. Larsson, AstraZeneca, Mölndal, Sweden; P. Latzin, University Children's Hospital of Bern, Bern, Switzerland; N. Lazarinis, Karolinska University Hospital & Karolinska Institutet, Stockholm, Sweden; N. Lemonnier, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; S. Lone-Latif, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; L.A. Lowe, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University Hospital of South Manchester, NHS Foundation Trust, Manchester, UK; A. Manta, Roche Diagnostics GmbH, Mannheim, Germany; L. Marouzet, NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK; J. Martin, NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK; C. Mathon, Centre of Allergy Research, Karolinska Institutet, Stockholm, Sweden; L. McEvoy, University Hospital, Dept of Pulmonary Medicine, Bern, Switzerland; S. Meah, National Heart and Lung Institute, Imperial College, London, UK; A. Menzies-Gow, Royal Brompton and Harefield NHS Foundation Trust, London, UK; L. Metcalf, previously at Asthma UK, London, UK; M. Mikus, Science for Life Laboratory & The Royal Institute of Technology, Stockholm, Sweden; P. Monk, Synairgen Research Ltd, Southampton, UK; S. Naz, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; K. Nething, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; B. Nicholas, University of Southampton, Southampton, UK; U. Nihlén, previously at AstraZeneca, Mölndal, Sweden; Peter Nilsson, Science for Life Laboratory & The Royal Institute of Technology, Stockholm, Sweden; R. Niven, North West Severe Asthma Network, University Hospital South Manchester, UK; B. Nordlund, Dept Women's and Children's Health & Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; S. Nsubuga, Royal Brompton Hospital, London, UK; J. Östling, AstraZeneca, Mölndal, Sweden; A. Pacino, Lega Italiano Anti Fumo, Catania, Italy; S. Palkonen, European Federation of Allergy and Airways Diseases Patient's Associations, Brussels, Belgium; J. Pellet, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; G. Pennazza, University of Rome ‘Tor Vergata’, Rome Italy; A. Petrén, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; S. Pink, NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK; C. Pison, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; A. Postle, University of Southampton, UK; M. Rahman-Amin, previously at Asthma UK, London, UK; L. Ravanetti, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; E. Ray, NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK; S. Reinke, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; L. Reynolds, previously at Asthma UK, London, UK; K. Riemann, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; Martine Robberechts, MSD, Brussels, Belgium; J.P. Rocha, Royal Brompton and Harefield NHS Foundation Trust, UK; C. Rossios, National Heart and Lung Institute, Imperial College, London, UK; K. Russell, National Heart and Lung Institute, Imperial College, London, UK; M. Rutgers, Longfonds, Amersfoort, The Netherlands; G. Santini, Università Cattolica del Sacro Cuore, Milan, Italy; M. Santoninco, University of Rome “Tor Vergata”, Rome Italy; M. Saqi, European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Lyon, France; C. Schoelch, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; J.P.R. Schofield, Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton, UK; S. Scott, North West Severe Asthma Network, Countess of Chester Hospital, UK; N. Sehgal, North West Severe Asthma Network, Pennine Acute Hospital NHS Trust; M. Sjödin, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; B. Smids, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Caroline Smith, NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK; J. Smith, Asthma UK, London, UK; K.M. Smith, University of Nottingham, UK; P. Söderman, Dept Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; A. Sogbessan, Royal Brompton and Harefield NHS Foundation Trust, London, UK; F. Spycher, University Hospital Dept of Pulmonary Medicine, Bern, Switzerland; D. Staykova, University of Southampton, Southampton, UK; S. Stephan, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University Hospital of South Manchester, NHS Foundation Trust, Manchester, UK; J. Stokholm, University of Copenhagen and Danish Pediatric Asthma Centre Denmark; K. Strandberg, Karolinska University Hospital & Karolinska Institutet, Stockholm, Sweden; M. Sunther, Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University Hospital of South Manchester, NHS Foundation Trust, Manchester, UK; M. Szentkereszty, Semmelweis University, Budapest, Hungary; L. Tamasi, Semmelweis University, Budapest, Hungary; K. Tariq, NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, NIHR-Wellcome Trust Clinical Research Facility, Faculty of Medicine, University of Southampton, Southampton, UK; J-O. Thörngren, Karolinska University Hospital, Stockholm, Sweden; Jonathan Thorsen, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; S. Valente, Università Cattolica del Sacro Cuore, Milan, Italy; Marianne van de Pol, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; C.M. van Drunen, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; J. Van Eyll, UCB, Slough, UK; J. Versnel, previously at Asthma UK, London, UK; A. Vink, Philips Research Laboratories, Eindhoven, The Netherlands; C. von Garnier, University Hospital Bern, Switzerland; A. Vyas, North West Severe Asthma Network, Lancashire Teaching Hospitals NHS Trust, UK; F. Wald, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; S. Walker, Asthma UK, London, UK; J. Ward, Histochemistry Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK; K. Wetzel, Boehringer Ingelheim Pharma GmbH, Biberach, Germany; C. Wiegman, National Heart and Lung Institute, Imperial College, London, UK; S. Williams, International Primary Care Respiratory Group, Aberdeen, UK; X. Yang, Data Science Institute, Imperial College, London, UK; E. Yeyasingham, UK Clinical Operations, GSK, Stockley Park, UK; W. Yu, Amgen Inc., Thousand Oaks, USA; W. Zetterquist, Dept Women's and Children's Health & Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Z. Zolkipli, NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK; A.H. Zwinderman, Academic Medical Centre, University of Amsterdam, The Netherlands. Partner organisations: Novartis Pharma AG; University of Southampton, Southampton, UK; Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Imperial College London, London, UK; University of Catania, Catania, Italy; University of Rome “Tor Vergata”, Rome, Italy; Hvidore Hospital, Hvidore, Denmark; Jagiellonian Univ. Medi. College, Krakow, Poland; University Hospital, Inselspital, Bern, Switzerland; Semmelweis University, Budapest, Hungary; University of Manchester, Manchester, UK; Université d'Aix-Marseille, Marseille, France; Fraunhofer Institute, Hannover, Germany; University Hospital, Umea, Sweden; Ghent University, Ghent, Belgium; Ctr. Nat. Recherche Scientifique, Lyon, France; Università Cattolica del Sacro Cuore, Rome, Italy; University Hospital, Copenhagen, Denmark; Karolinska Institutet, Stockholm, Sweden; Nottingham University Hospital, Nottingham, UK; University of Bergen, Bergen, Norway; Netherlands Asthma Foundation, Leusden, The Netherlands; European Lung Foundation, Sheffield, UK; Asthma UK, London, UK; European. Fed. of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium; Lega Italiano Anti Fumo, Catania, Italy; International Primary Care Respiratory Group, Aberdeen, UK; Philips Research Laboratories, Eindhoven, The Netherlands; Synairgen Research Ltd, Southampton, UK; Aerocrine AB, Stockholm, Sweden; BioSci Consulting, Maasmechelen, Belgium; Almirall; AstraZeneca; Boehringer Ingelheim; Chiesi; GlaxoSmithKline; Roche; UCB; Janssen Biologics BV; Amgen NV; Merck Sharp & Dome Corp. Members of the ethics board: J-B. Prins, biomedical research, LUMC, The Netherlands; M. Gahlemann, clinical care, BI, Germany; L. Visintin, legal affairs, LIAF, Italy; H. Evans, paediatric care, Southampton, UK; M. Puhl, patient representation (co-chair), NAF, The Netherlands; L. Buzermaniene, patient representation, EFA, Lithuania; V. Hudson, patient representation, Asthma UK; L. Bond, patient representation, Asthma UK; P. de Boer, patient representation and pathobiology, IND; G. Widdershoven, research ethics, VUMC, The Netherlands; R. Sigmund, research methodology and biostatistics, BI, Germany. The patient input platform: A. Roberts, UK; D. Supple (chair), UK; D. Hamerlijnck, The Netherlands; J. Negus, UK; J. Kamphuis, The Netherlands; L. Sergison, UK; L. Visintin, Italy; P. de Boer (co-chair), The Netherlands; S. Onstein, The Netherlands. Members of the safety monitoring board: W. MacNee, clinical care; R. Bernardini, clinical pharmacology; Louis Bont, paediatric care and infectious diseases; P-A. Wecksell, patient representation; P. de Boer, patient representation and pathobiology (chair); M. Gahlemann, patient safety advice and clinical care (co-chair); R. Sigmund, bio-informatician.
Support statement: U-BIOPRED is supported through an Innovative Medicines Initiative Joint Undertaking under grant agreement number 115010, resources of which are composed of financial contribution from the European Union's Seventh Framework Program (FP7/2007–2013) and European Federation of Pharmaceutical Industries and Associations companies' in-kind contribution (www.imi.europa.eu). J.M. Perotin was supported by the European Respiratory Society (fellowship LTRF 2017), Association Régionale pour l'Aide aux Insuffisants Respiratoires de Champagne-Ardenne, Association Nationale de Formation Continue en Allergologie, Association des Allergologues de Champagne-Ardenne and Association des Pneumologues de Champagne-Ardenne. Funding information for this article has been deposited with the Crossref Funder Registry.
Author contributions: Substantial contributions to the conception or design of the work: J.M. Perotin, J.P.R. Schofield, D.E. Davies and R. Djukanović. Acquisition, analysis, or interpretation of data: J.M. Perotin, J.P.R. Schofield, J. Brandsma, F. Strazzeri, A. Bansal, X. Yang, A. Rowe, J. Corfield, S.J. Wilson, J. Ward, R. Lutter, D.E. Shaw, P.S. Bakke, M. Caruso, B. Dahlén, S.J. Fowler, I. Horváth, P. Howarth, N. Krug, P. Montuschi, M. Sanak, T. Sandström, K. Sun, I. Pandis, C. Auffray, B. De Meulder, D. Lefaudeux, J.H. Riley, A.R. Sousa, S-E. Dahlen, I.M. Adcock, K.F. Chung, P.J. Sterk, P.J. Skipp, D.E. Davies and R. Djukanović. Drafting the manuscript or revising it critically for important intellectual content: J-M. Perotin, J.P.R. Schofield, J.E. Collins, D.E. Davies and R. Djukanović. Final approval of the manuscript version to be published: all authors.
Conflict of interest: J.M. Perotin has nothing to disclose.
Conflict of interest: J.P.R. Schofield has nothing to disclose.
Conflict of interest: S.J. Wilson has nothing to disclose.
Conflict of interest: J. Ward has nothing to disclose.
Conflict of interest: J. Brandsma has nothing to disclose.
Conflict of interest: F. Strazzeri has nothing to disclose.
Conflict of interest: A. Bansal has nothing to disclose.
Conflict of interest: X. Yang has nothing to disclose.
Conflict of interest: A. Rowe is a full-time employee and shareholder of Janssen Pharmaceutical Companies of Johnson and Johnson.
Conflict of interest: J. Corfield has nothing to disclose.
Conflict of interest: R. Lutter has nothing to disclose.
Conflict of interest: D.E. Shaw reports fees for lectures at company sponsored symposia and support to attend an international conference from AstraZeneca, fees for lectures at company sponsored symposia and investigator-initiated research funding from Boehringer Ingelheim, fees for lectures at company sponsored symposia from Novartis and Teva, a fee for presentation from Circassia, and a grant for an investigator led study from GSK, outside the submitted work.
Conflict of interest: P.S. Bakke reports personal fees from GSK, AZ, Novartis andTeva, outside the submitted work.
Conflict of interest: M. Caruso has no conflict of interest to disclose.
Conflict of interest: B. Dahlén has nothing to disclose.
Conflict of interest: S.J. Fowler reports personal fees and non-financial support from AstraZeneca, grants and personal fees from Boehringer Ingelheim, and personal fees from Novartis and Teva, outside the submitted work.
Conflict of interest: I. Horváth reports personal fees from Astra Zeneca, Boehringer Ingelheim, Novartis, CSL, Chiesi, Roche, GSK, Berlin-Chemie and Sandoz, outside the submitted work.
Conflict of interest: P. Howarth reports personal fees from GSK, outside the submitted work.
Conflict of interest: N. Krug has nothing to disclose.
Conflict of interest: P. Montuschi has nothing to disclose.
Conflict of interest: M. Sanak has nothing to disclose.
Conflict of interest: T. Sandström reports Fees for lectures and course arrangement from Boehringer Ingelheim, outside the submitted work.
Conflict of interest: K. Sun has nothing to disclose.
Conflict of interest: I. Pandis has nothing to disclose.
Conflict of interest: C. Auffray reports grants from Innovative Medicine Initiative, during the conduct of the study.
Conflict of interest: B. De Meulder reports grants from Innovative Medicine Initiative, during the conduct of the study.
Conflict of interest: D. Lefaudeux reports grants from Innovative Medicine Initiative, grants from Innovative Medicine Initiative, during the conduct of the study.
Conflict of interest: J.H. Riley reports that he has shares in and is employed by GSK.
Conflict of interest: A.R. Sousa has nothing to disclose.
Conflict of interest: S-E. Dahlén has nothing to disclose.
Conflict of interest: I.M. Adcock reports grants from EU-IMI, during the conduct of the study.
Conflict of interest: K.F. Chung has received honoraria for participating in Advisory Board meetings of GSK, AZ, BI, Teva, Novartis and Merck regarding treatments for asthma and chronic obstructive pulmonary disease, and has also been renumerated for speaking engagements.
Conflict of interest: P.J. Sterk reports grants from Innovative Medicines Initiative, during the conduct of the study.
Conflict of interest: P.J. Skipp has nothing to disclose.
Conflict of interest: J.E. Collins reports a patent application for use of a genetically modified Drosophila line carrying one or more mammalian genes associated with a chronic respiratory disease and uses to screen the impact of such genes.
Conflict of interest: D.E. Davies has nothing to disclose.
Conflict of interest: R. Djukanović reports receiving fees for lectures at symposia organised by Novartis, AstraZeneca and TEVA, consultation for TEVA and Novartis as member of advisory boards, and participation in a scientific discussion about asthma organised by GlaxoSmithKline. He is a co-founder and current consultant, and has shares in Synairgen, a University of Southampton spin out company.
- Received December 17, 2018.
- Accepted March 20, 2019.
- Copyright ©ERS 2019
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