Extract
In a large subset of patients with asthma, blood eosinophilia is common, as a marker of T-helper type 2 cell (Th2) inflammation. Hypereosinophilia (HE), defined by blood eosinophil count >1500 per mm3, is rare, observed in 0.3% of asthmatic patients [1]. Classically, in the context of uncontrolled asthma and HE, allergic bronchopulmonary aspergillosis, vasculitis or parasitic infection must be investigated [2]. Asthma is also a feature of HE related to various haematological disorders, although respiratory manifestations are rarely isolated in this setting [2].
Abstract
Hypereosinophilia (blood eosinophil count >1500 per mm3) in asthma patients may hide some rare myeloid or lymphoid neoplasms. Their identification has prognostic and therapeutic relevance because of the potential for targeted therapy. http://bit.ly/2JCoVIA
Footnotes
Conflict of interest: L. Tabèze has nothing to disclose.
Conflict of interest: S. Marchand-Adam has nothing to disclose.
Conflict of interest: R. Borie reports grants and personal fees from Boehringer Ingelheim and Roche, outside the submitted work.
Conflict of interest: A. Justet has nothing to disclose.
Conflict of interest: C. Dupin has nothing to disclose.
Conflict of interest: M-C. Dombret has nothing to disclose.
Conflict of interest: B. Crestani reports research and travel grants and personal fees for lecturing from Boehringer Ingelheim and Roche, travel grants from Apellis, personal fees for travel and lecturing from AstraZeneca and Sanofi, grants from Medimmune, outside the submitted work.
Conflict of interest: C. Taillé reports personal fees from and acting as study investigator for AstraZeneca, Boehringer, Novartis and ALK, personal fees from Chiesi and Teva, grants and personal fees from and acting as study investigator for GSK, acting as study investigator for Sanofi, outside the submitted work.
- Received November 29, 2019.
- Accepted March 3, 2019.
- Copyright ©ERS 2019
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