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Table of Contents

01 May 2019; volume 53, issue 5

Editorials

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    New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough
    Lorcan McGarvey, Lieven Dupont, Surinder S. Birring, Jeanette Boyd, Kian Fan Chung, Marta Dabrowska, Christian Domingo, Giovanni Fontana, Laurent Guilleminault, Peter Kardos, Eva Millqvist, Alyn H. Morice, Jaclyn A. Smith, Jan Willem van den Berg, Charlotte Van de Kerkhove on behalf of the NEUROCOUGH Clinical Research Collaboration
    European Respiratory Journal 53 (5) 1900787; DOI: 10.1183/13993003.00787-2019 Published 30 May 2019
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    The Ariane-IPF ERS Clinical Research Collaboration: seeking collaboration through launch of a federation of European registries on idiopathic pulmonary fibrosis
    Vincent Cottin, Isabella Annesi-Maesano, Andreas Günther, Liam Galvin, Michael Kreuter, Pippa Powell, Antje Prasse, George Reynolds, Luca Richeldi, Paolo Spagnolo, Claudia Valenzuela, Marlies Wijsenbeek, Wim A. Wuyts, Bruno Crestani on behalf of the Ariane-IPF Clinical Research Collaboration consortium
    European Respiratory Journal 53 (5) 1900539; DOI: 10.1183/13993003.00539-2019 Published 23 May 2019
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    The International Collaborative Effusion (ICE) database: an ERS Clinical Research Collaboration
    Rahul Bhatnagar, Julius Janssen, Nick Maskell
    European Respiratory Journal 53 (5) 1900591; DOI: 10.1183/13993003.00591-2019 Published 2 May 2019
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    It needs more than just eosinophils to cause emphysema in COPD
    Florence Schleich, Renaud Louis
    European Respiratory Journal 53 (5) 1900332; DOI: 10.1183/13993003.00332-2019 Published 30 May 2019
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    Supplemental oxygen during exercise training in COPD: full of hot air?
    Jessica A. Walsh, Matthew Maddocks, William D-C. Man
    European Respiratory Journal 53 (5) 1900837; DOI: 10.1183/13993003.00837-2019 Published 30 May 2019
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    Guiding antibiotic treatment with inflammatory biomarkers in COPD? Another brick in the wall
    Philipp Schuetz, Daiana Stolz
    European Respiratory Journal 53 (5) 1900562; DOI: 10.1183/13993003.00562-2019 Published 23 May 2019
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    Is it still relevant to consider polysomnography as essential for noninvasive ventilation titration?
    Jean-Christian Borel, Jesus Gonzalez-Bermejo
    European Respiratory Journal 53 (5) 1900619; DOI: 10.1183/13993003.00619-2019 Published 23 May 2019
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    Less is more: the impact of maintenance treatment adherence in severe asthma clinical trials
    Claire N. McBrien, Andrew Menzies-Gow
    European Respiratory Journal 53 (5) 1900599; DOI: 10.1183/13993003.00599-2019 Published 18 May 2019
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    A crossroads between the heart and lungs: air pollution and pulmonary hypertension
    Meredith C. McCormack, Stephen C. Mathai
    European Respiratory Journal 53 (5) 1900654; DOI: 10.1183/13993003.00654-2019 Published 30 May 2019
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    Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension: is Europe behind?
    Irene M. Lang, Hiromi Matsubara
    European Respiratory Journal 53 (5) 1900843; DOI: 10.1183/13993003.00843-2019 Published 23 May 2019
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    Novel techniques for advancing our understanding of pulmonary arterial hypertension
    Emily M. Beck, Nathan D. Hatton, John J. Ryan
    European Respiratory Journal 53 (5) 1900556; DOI: 10.1183/13993003.00556-2019 Published 9 May 2019
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    Chronic cough: a disorder of response inhibition?
    Stuart B. Mazzone
    European Respiratory Journal 53 (5) 1900254; DOI: 10.1183/13993003.00254-2019 Published 2 May 2019

Original Articles

  • Airways disease and basic science

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      Eosinophil-derived IL-13 promotes emphysema
      Alfred D. Doyle, Manali Mukherjee, William E. LeSuer, Tyler B. Bittner, Saif M. Pasha, Justin J. Frere, Joseph L. Neely, Jake A. Kloeber, Kelly P. Shim, Sergei I. Ochkur, Terence Ho, Sarah Svenningsen, Benjamin L. Wright, Matthew A. Rank, James J. Lee, Parameswaran Nair, Elizabeth A. Jacobsen
      European Respiratory Journal 53 (5) 1801291; DOI: 10.1183/13993003.01291-2018 Published 30 May 2019
  • COPD

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      Oxygen compared to air during exercise training in COPD with exercise-induced desaturation
      Jennifer A. Alison, Zoe J. McKeough, Regina W.M. Leung, Anne E. Holland, Kylie Hill, Norman R. Morris, Sue Jenkins, Lissa M. Spencer, Catherine J. Hill, Annemarie L. Lee, Helen Seale, Nola Cecins, Christine F. McDonald
      European Respiratory Journal 53 (5) 1802429; DOI: 10.1183/13993003.02429-2018 Published 30 May 2019
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      CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions
      H.J. Prins, Ruud Duijkers, Paul van der Valk, Marianne Schoorl, Johannes M.A. Daniels, Tjip S. van der Werf, Wim G. Boersma
      European Respiratory Journal 53 (5) 1802014; DOI: 10.1183/13993003.02014-2018 Published 23 May 2019
  • Sleep medicine

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      Randomised controlled trial of polysomnographic titration of noninvasive ventilation
      Liam M. Hannan, Linda Rautela, David J. Berlowitz, Christine F. McDonald, Jennifer M. Cori, Nicole Sheers, Caroline Chao, Fergal J. O'Donoghue, Mark E. Howard
      European Respiratory Journal 53 (5) 1802118; DOI: 10.1183/13993003.02118-2018 Published 23 May 2019
  • Asthma

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      Asthma and affective traits in adults: a genetically informative study
      Kelli Lehto, Nancy L. Pedersen, Catarina Almqvist, Yi Lu, Bronwyn K. Brew
      European Respiratory Journal 53 (5) 1802142; DOI: 10.1183/13993003.02142-2018 Published 30 May 2019
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      Dampness, mould, onset and remission of adult respiratory symptoms, asthma and rhinitis
      Juan Wang, Mihkel Pindus, Christer Janson, Torben Sigsgaard, Jeong-Lim Kim, Mathias Holm, Johan Sommar, Hans Orru, Thorarinn Gislason, Ane Johannessen, Randi J. Bertelsen, Dan Norbäck
      European Respiratory Journal 53 (5) 1801921; DOI: 10.1183/13993003.01921-2018 Published 23 May 2019
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      Inadequate assessment of adherence to maintenance medication leads to loss of power and increased costs in trials of severe asthma therapy: results from a systematic literature review and modelling study
      Matshediso C. Mokoka, Melissa J. McDonnell, Elaine MacHale, Breda Cushen, Fiona Boland, Sarah Cormican, Christina Doherty, Frank Doyle, Richard W. Costello, Garrett Greene
      European Respiratory Journal 53 (5) 1802161; DOI: 10.1183/13993003.02161-2018 Published 18 May 2019
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      Prescribed analgesics in pregnancy and risk of childhood asthma
      Seif O. Shaheen, Cecilia Lundholm, Bronwyn K. Brew, Catarina Almqvist
      European Respiratory Journal 53 (5) 1801090; DOI: 10.1183/13993003.01090-2018 Published 18 May 2019
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      Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents
      Yale Jiang, Olena Gruzieva, Ting Wang, Erick Forno, Nadia Boutaoui, Tao Sun, Simon K. Merid, Edna Acosta-Pérez, Inger Kull, Glorisa Canino, Josep M. Antó, Jean Bousquet, Erik Melén, Wei Chen, Juan C. Celedón
      European Respiratory Journal 53 (5) 1900102; DOI: 10.1183/13993003.00102-2019 Published 18 May 2019
  • Basic science

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      Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes
      Wu-Lin Zuo, Jing Yang, Yael Strulovici-Barel, Jacqueline Salit, Mahboubeh Rostami, Jason G. Mezey, Sarah L. O'Beirne, Robert J. Kaner, Ronald G. Crystal
      European Respiratory Journal 53 (5) 1702553; DOI: 10.1183/13993003.02553-2017 Published 18 May 2019
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  • Pulmonary hypertension

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      Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis
      Eleni Sofianopoulou, Stephen Kaptoge, Stefan Gräf, Charaka Hadinnapola, Carmen M. Treacy, Colin Church, Gerry Coghlan, J. Simon R. Gibbs, Matthias Haimel, Luke S. Howard, Martin Johnson, David G. Kiely, Allan Lawrie, James Lordan, Robert V. MacKenzie Ross, Jennifer M. Martin, Shahin Moledina, Michael Newnham, Andrew J. Peacock, Laura C. Price, Christopher J. Rhodes, Jay Suntharalingam, Emilia M. Swietlik, Mark R. Toshner, John Wharton, Martin R. Wilkins, Stephen J. Wort, Joanna Pepke-Zaba, Robin Condliffe, Paul A. Corris, Emanuele Di Angelantonio, Steeve Provencher, Nicholas W. Morrell
      European Respiratory Journal 53 (5) 1801429; DOI: 10.1183/13993003.01429-2018 Published 30 May 2019
    • Open Access
      French experience of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
      Philippe Brenot, Xavier Jaïs, Yu Taniguchi, Carlos Garcia Alonso, Benoit Gerardin, Sacha Mussot, Olaf Mercier, Dominique Fabre, Florence Parent, Mitja Jevnikar, David Montani, Laurent Savale, Olivier Sitbon, Elie Fadel, Marc Humbert, Gérald Simonneau
      European Respiratory Journal 53 (5) 1802095; DOI: 10.1183/13993003.02095-2018 Published 18 May 2019
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      Pulmonary arterial hypertension associated with protein kinase inhibitors: a pharmacovigilance–pharmacodynamic study
      Lucie Cornet, Charles Khouri, Matthieu Roustit, Christophe Guignabert, Marie-Camille Chaumais, Marc Humbert, Bruno Revol, Fabien Despas, David Montani, Jean-Luc Cracowski
      European Respiratory Journal 53 (5) 1802472; DOI: 10.1183/13993003.02472-2018 Published 9 May 2019
  • Lung cancer

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      Centrally located lung cancer and risk of occult nodal disease: an objective evaluation of multiple definitions of tumour centrality with dedicated imaging software
      Roberto F. Casal, Boris Sepesi, Ala-Eddin S. Sagar, Juerg Tschirren, Minxing Chen, Liang Li, Jennifer Sunny, Joyce Williams, Horiana B. Grosu, George A. Eapen, Carlos A. Jimenez, David E. Ost
      European Respiratory Journal 53 (5) 1802220; DOI: 10.1183/13993003.02220-2018 Published 9 May 2019
  • Interstitial lung disease

    • Open Access
      Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion
      Tomoyuki Fujisawa, Kazutaka Mori, Masashi Mikamo, Takashi Ohno, Kensuke Kataoka, Chikatoshi Sugimoto, Hideya Kitamura, Noriyuki Enomoto, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Mikiko Hashisako, Tomonori Tanaka, Yasuhiro Terasaki, Shinobu Kunugi, Masashi Kitani, Ryo Okuda, Yasuoki Horiike, Yasunori Enomoto, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Yutaro Nakamura, Junya Fukuoka, Takeshi Johkoh, Yasuhiro Kondoh, Takashi Ogura, Yoshikazu Inoue, Yoshinori Hasegawa, Naohiko Inase, Sakae Homma, Takafumi Suda
      European Respiratory Journal 53 (5) 1802243; DOI: 10.1183/13993003.02243-2018 Published 18 May 2019
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      Patient-reported distress can aid clinical decision-making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort
      Iain Stewart, Tricia McKeever, Rebecca Braybrooke, Eunice Oballa, Juliet K. Simpson, Toby M. Maher, Richard P. Marshall, Pauline T. Lukey, William A. Fahy, Gisli Jenkins, Gauri Saini
      European Respiratory Journal 53 (5) 1801925; DOI: 10.1183/13993003.01925-2018 Published 9 May 2019
  • Cough

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      Impaired cough suppression in chronic refractory cough
      Peter S.P. Cho, Hannah V. Fletcher, Richard D. Turner, Caroline J. Jolley, Surinder S. Birring
      European Respiratory Journal 53 (5) 1802203; DOI: 10.1183/13993003.02203-2018 Published 2 May 2019
  • Cystic fibrosis

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      Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis
      Jonathan H. Rayment, Marcus J. Couch, Nancy McDonald, Nikhil Kanhere, David Manson, Giles Santyr, Felix Ratjen
      European Respiratory Journal 53 (5) 1802188; DOI: 10.1183/13993003.02188-2018 Published 2 May 2019
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      Quantitative multivolume proton-magnetic resonance imaging in patients with cystic fibrosis lung disease: comparison with clinical indicators
      Francesca Pennati, Caterina Salito, Irene Borzani, Giulia Cervellin, Simone Gambazza, Riccardo Guarise, Maria Chiara Russo, Carla Colombo, Andrea Aliverti
      European Respiratory Journal 53 (5) 1702020; DOI: 10.1183/13993003.02020-2017 Published 2 May 2019
  • Paediatrics

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      Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry
      Laura L. Walkup, Kasiani Myers, Javier El-Bietar, Adam Nelson, Matthew M. Willmering, Michael Grimley, Stella M. Davies, Christopher Towe, Jason C. Woods
      European Respiratory Journal 53 (5) 1801779; DOI: 10.1183/13993003.01779-2018 Published 2 May 2019

Reviews

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    Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019
    Dave Singh, Alvar Agusti, Antonio Anzueto, Peter J. Barnes, Jean Bourbeau, Bartolome R. Celli, Gerard J. Criner, Peter Frith, David M.G. Halpin, Meilan Han, M. Victorina López Varela, Fernando Martinez, Maria Montes de Oca, Alberto Papi, Ian D. Pavord, Nicolas Roche, Donald D. Sin, Robert Stockley, Jørgen Vestbo, Jadwiga A. Wedzicha, Claus Vogelmeier
    European Respiratory Journal 53 (5) 1900164; DOI: 10.1183/13993003.00164-2019 Published 18 May 2019
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    Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report
    Vanessa M. McDonald, James Fingleton, Alvar Agusti, Sarah A. Hiles, Vanessa L. Clark, Anne E. Holland, Guy B. Marks, Philip P. Bardin, Richard Beasley, Ian D. Pavord, Peter A.B. Wark, Peter G. Gibson on behalf of the participants of the Treatable Traits Down Under International Workshop
    European Respiratory Journal 53 (5) 1802058; DOI: 10.1183/13993003.02058-2018 Published 9 May 2019

Agora

  • Research letters

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      Exhaled nitric oxide in stable adult cystic fibrosis patients, during exacerbation and following CFTR-modifying treatment
      Stefanie Vincken, Sylvia Verbanck, Elke De Wachter, Eef Vanderhelst
      European Respiratory Journal 53 (5) 1802259; DOI: 10.1183/13993003.02259-2018 Published 30 May 2019
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      Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis
      Christina Lancioni, Gwendolyn M. Swarbrick, Byung Park, Melissa Nyendak, Mary Nsereko, Harriet Mayanja-Kizza, Megan D. Null, Meghan E. Cansler, Rowan B. Duncan, Joy Baseke, Keith Chervenak, LaShaunda Malone, Emily G. Heaphy, W. Henry Boom, David M. Lewinsohn, Deborah A. Lewinsohn
      European Respiratory Journal 53 (5) 1802053; DOI: 10.1183/13993003.02053-2018 Published 30 May 2019
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      Unresolved issues in treatment outcome definitions for nontuberculous mycobacterial pulmonary disease
      Seong Mi Moon, Byung Woo Jhun, Charles L. Daley, Won-Jung Koh
      European Respiratory Journal 53 (5) 1801636; DOI: 10.1183/13993003.01636-2018 Published 23 May 2019
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      In patients with idiopathic pulmonary fibrosis the presence of hiatus hernia is associated with disease progression and mortality
      John A. Mackintosh, Sujal R. Desai, Huzaifa Adamali, Kinesh Patel, Felix Chua, Anand Devaraj, Vasilis Kouranos, Maria Kokosi, George Margaritopoulos, Elisabetta A. Renzoni, Athol U. Wells, Philip L. Molyneaux, Sacheen Kumar, Toby M. Maher, Peter M. George
      European Respiratory Journal 53 (5) 1802412; DOI: 10.1183/13993003.02412-2018 Published 23 May 2019
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      The withdrawal of replacement therapy and outcomes in alpha-1 antitrypsin deficiency lung transplant recipients
      Jana Kleinerova, Patricia Ging, Colin Rutherford, Iain Lawrie, Sara Winward, Donna Eaton, Karen C. Redmond, Jim J. Egan
      European Respiratory Journal 53 (5) 1900055; DOI: 10.1183/13993003.00055-2019 Published 18 May 2019
    • Open Access
      Extrafine triple therapy in patients with symptomatic COPD and history of one moderate exacerbation
      Dave Singh, Leonardo M. Fabbri, Massimo Corradi, George Georges, Alessandro Guasconi, Stefano Vezzoli, Stefano Petruzzelli, Alberto Papi
      European Respiratory Journal 53 (5) 1900235; DOI: 10.1183/13993003.00235-2019 Published 18 May 2019
    • You have accessRestricted access
      Return of sleep apnoea and sleep fragmentation following CPAP withdrawal in patients with obstructive sleep apnoea
      Chris Turnbull, Saxon Pattenden, Thomas Gaisl, Valentina Rossi, Sira Thiel, Malcolm Kohler, John Stradling
      European Respiratory Journal 53 (5) 1802351; DOI: 10.1183/13993003.02351-2018 Published 9 May 2019
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      To rout or snort in the sleepe: a detailed medical description of sleep disordered breathing and its consequences by Georg Grau in 1688
      Sven Rupprecht, Doris Schönefeld, Nasim Kroegel, Otto W. Witte, Matthias Schwab, Ekkehart Paditz
      European Respiratory Journal 53 (5) 1801799; DOI: 10.1183/13993003.01799-2018 Published 9 May 2019
    • You have accessRestricted access
      Easy-to-build and affordable continuous positive airway pressure CPAP device for adult patients in low-income countries
      Ramon Farré, Josep M. Montserrat, Gorka Solana, David Gozal, Daniel Navajas
      European Respiratory Journal 53 (5) 1802290; DOI: 10.1183/13993003.02290-2018 Published 2 May 2019
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      Pulmonary physiology is poorly associated with radiological extent of disease in systemic sclerosis-associated interstitial lung disease
      Amrit Jhajj, Harinder Pal Gill, Cameron J. Hague, Darra Murphy, Brett Elicker, Jeanette Soon, Nada Sulaiman, Daniela Castillo-Saldana, Pearce G. Wilcox, James Dunne, Joyce S. Lee, Paul J. Wolters, Brett Ley, Kirk D. Jones, Julie Morisset, Christopher J. Ryerson
      European Respiratory Journal 53 (5) 1802182; DOI: 10.1183/13993003.02182-2018 Published 2 May 2019
  • Correspondence

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      Malnutrition in idiopathic pulmonary fibrosis: the great forgotten comorbidity!
      Stéphane Jouneau, Mathieu Lederlin, Laurent Vernhet, Ronan Thibault
      European Respiratory Journal 53 (5) 1900418; DOI: 10.1183/13993003.00418-2019 Published 9 May 2019
    • You have accessRestricted access
      Reply to: Malnutrition in idiopathic pulmonary fibrosis: the great forgotten comorbidity!
      Sebastiano Emanuele Torrisi, Brett Ley, Michael Kreuter, Marlies Wijsenbeek, Eric Vittinghoff, Harold R. Collard, Carlo Vancheri
      European Respiratory Journal 53 (5) 1900615; DOI: 10.1183/13993003.00615-2019 Published 9 May 2019
    • You have accessRestricted access
      Declining trend in incidence of tuberculosis in adolescents and young adults in Taiwan
      Ying-Ying Chen, Sheng-Wei Pan, Hsiang-Shi Shen, Fan-Yi Chuang, Jia-Yih Feng, Wei-Juin Su
      European Respiratory Journal 53 (5) 1801305; DOI: 10.1183/13993003.01305-2018 Published 2 May 2019
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