Table of Contents

Original Articles

• Environment and the lung

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    Benefits of improved air quality on ageing lungs: impacts of genetics and obesity

    Anke Hüls, Dorothee Sugiri, Michael J. Abramson, Barbara Hoffmann, Holger Schwender, Katja Ickstadt, Ursula Krämer, Tamara Schikowski

    European Respiratory Journal 53 (4) 1801780; DOI: 10.1183/13993003.01780-2018 Published 25 April 2019

• COPD

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    Interdisciplinary COPD intervention in primary care: a cluster randomised controlled trial

    Jenifer Liang, Michael J. Abramson, Grant Russell, Anne E. Holland, Nicholas A. Zwar, Billie Bonevski, Ajay Mahal, Paula Eustace, Eldho Paul, Kirsten Phillips, Narelle S. Cox, Sally Wilson, Johnson George

    European Respiratory Journal 53 (4) 1801530; DOI: 10.1183/13993003.01530-2018 Published 25 April 2019
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    Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD

    Alen Faiz, Katrina Steiling, Mirjam P. Roffel, Dirkje S. Postma, Avrum Spira, Marc E. Lenburg, Malte Borggrewe, Tim R. Eijgenraam, Marnix R. Jonker, Gerard H. Koppelman, Simon D. Pouwels, Gang Liu, Yuriy O. Alekseyev, Stephen Lam, Pieter S. Hiemstra, Peter J. Sterk, Wim Timens, Corry-Anke Brandsma, Irene H. Heijink, Maarten van den Berge

    European Respiratory Journal 53 (4) 1801202; DOI: 10.1183/13993003.01202-2018 Published 25 April 2019
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    Exercise intolerance in comorbid COPD and heart failure: the role of impaired aerobic function

    Alcides Rocha, Flavio F. Arbex, Priscila A. Sperandio, Frederico Mancuso, Mathieu Marillier, Anne-Catherine Bernard, Maria Clara N. Alencar, Denis E. O'Donnell, J. Alberto Neder

    European Respiratory Journal 53 (4) 1802386; DOI: 10.1183/13993003.02386-2018 Published 18 April 2019

• Cystic fibrosis

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    Effects of exercise and airway clearance (positive expiratory pressure) on mucus clearance in cystic fibrosis: a randomised crossover trial

    Tiffany J. Dwyer, Evangelia Daviskas, Rahizan Zainuldin, Jordan Verschuer, Stefan Eberl, Peter T.P. Bye, Jennifer A. Alison

    European Respiratory Journal 53 (4) 1801793; DOI: 10.1183/13993003.01793-2018 Published 18 April 2019

• Tuberculosis

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    Latent tuberculosis infection in healthcare workers in low- and middle-income countries: an updated systematic review

    Lika Apriani, Susan McAllister, Katrina Sharples, Bachti Alisjahbana, Rovina Ruslami, Philip C. Hill, Dick Menzies

    European Respiratory Journal 53 (4) 1801789; DOI: 10.1183/13993003.01789-2018 Published 18 April 2019

• Interstitial lung disease

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    Telomere length and genetic variant associations with interstitial lung disease progression and survival

    Chad A. Newton, Justin M. Oldham, Brett Ley, Vikram Anand, Ayodeji Adegunsoye, Gabrielle Liu, Kiran Batra, Jose Torrealba, Julia Kozlitina, Craig Glazer, Mary E. Strek, Paul J. Wolters, Imre Noth, Christine Kim Garcia

    European Respiratory Journal 53 (4) 1801641; DOI: 10.1183/13993003.01641-2018 Published 11 April 2019

• Lung structure and function

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    Artificial intelligence outperforms pulmonologists in the interpretation of pulmonary function tests

    Marko Topalovic, Nilakash Das, Pierre-Régis Burgel, Marc Daenen, Eric Derom, Christel Haenebalcke, Rob Janssen, Huib A.M. Kerstjens, Giuseppe Liistro, Renaud Louis, Vincent Ninane, Christophe Pison, Marc Schlesser, Piet Vercauter, Claus F. Vogelmeier, Emiel Wouters, Jokke Wynants, Wim Janssens on behalf of the Pulmonary Function Study Investigators

    European Respiratory Journal 53 (4) 1801660; DOI: 10.1183/13993003.01660-2018 Published 11 April 2019

• Respiratory clinical practice

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    Development of a prognostic model of respiratory insufficiency or death in amyotrophic lateral sclerosis

    Jason Ackrivo, John Hansen-Flaschen, E. Paul Wileyto, Richard J. Schwab, Lauren Elman, Steven M. Kawut

    European Respiratory Journal 53 (4) 1802237; DOI: 10.1183/13993003.02237-2018 Published 18 April 2019
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    Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks

    David S. Hui, Benny K. Chow, Thomas Lo, Owen T.Y. Tsang, Fanny W. Ko, Susanna S. Ng, Tony Gin, Matthew T.V. Chan

    European Respiratory Journal 53 (4) 1802339; DOI: 10.1183/13993003.02339-2018 Published 11 April 2019

• Basic science and asthma

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    IL-17F, rather than IL-17A, underlies airway inflammation in a steroid-insensitive toluene diisocyanate-induced asthma model

    Rongchang Chen, Qingling Zhang, Shuyu Chen, Haixiong Tang, Peikai Huang, Shushan Wei, Zhenyu Liang, Xin Chen, Ailin Tao, Lihong Yao

    European Respiratory Journal 53 (4) 1801510; DOI: 10.1183/13993003.01510-2018 Published 4 April 2019

• Asthma

  • Open Access

    The Electronic Asthma Management System (eAMS) improves primary care asthma management

    Samir Gupta, Courtney Price, Gina Agarwal, David Chan, Sanjeev Goel, Louis-Philippe Boulet, Alan G. Kaplan, Gerald Lebovic, Muhammad Mamdani, Sharon E. Straus

    European Respiratory Journal 53 (4) 1802241; DOI: 10.1183/13993003.02241-2018 Published 25 April 2019
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    Dynamic hyperinflation impairs daily life activity in asthma

    Akke-Nynke van der Meer, Kim de Jong, Aranka Hoekstra-Kuik, Elisabeth H. Bel, Anneke ten Brinke

    European Respiratory Journal 53 (4) 1801500; DOI: 10.1183/13993003.01500-2018 Published 11 April 2019
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    Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population-based cohort 2006–2016

    Chloe I. Bloom, Sejal Saglani, Johanna Feary, Debbie Jarvis, Jennifer K. Quint

    European Respiratory Journal 53 (4) 1802130; DOI: 10.1183/13993003.02130-2018 Published 4 April 2019

• Paediatrics and asthma

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    Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course

    Herman T. den Dekker, Kimberley Burrows, Janine F. Felix, Lucas A. Salas, Ivana Nedeljkovic, Jin Yao, Sheryl L. Rifas-Shiman, Carlos Ruiz-Arenas, N. Amin, Mariona Bustamante, Dawn L. DeMeo, A. John Henderson, Caitlin G. Howe, Marie-France Hivert, M. Arfan Ikram, Johan C. de Jongste, Lies Lahousse, Pooja R. Mandaviya, Joyce B. van Meurs, Mariona Pinart, Gemma C. Sharp, Lisette Stolk, André G. Uitterlinden, Josep M. Anto, Augusto A. Litonjua, Carrie V. Breton, Guy G. Brusselle, Jordi Sunyer, George Davey Smith, Caroline L. Relton, Vincent W.V. Jaddoe, Liesbeth Duijts

    European Respiratory Journal 53 (4) 1801795; DOI: 10.1183/13993003.01795-2018 Published 4 April 2019

• Rare lung diseases

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    Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis

    Nishant Gupta, Hye-Seung Lee, Lisa R. Young, Charlie Strange, Joel Moss, Lianne G. Singer, Koh Nakata, Alan F. Barker, Jeffrey T. Chapman, Mark L. Brantly, James M. Stocks, Kevin K. Brown, Joseph P. Lynch 3rd, Hilary J. Goldberg, Gregory P. Downey, Angelo M. Taveira-DaSilva, Jeffrey P. Krischer, Kenneth Setchell, Bruce C. Trapnell, Yoshikazu Inoue, Francis X. McCormack for the NIH Rare Lung Disease Consortium

    European Respiratory Journal 53 (4) 1802066; DOI: 10.1183/13993003.02066-2018 Published 4 April 2019