Total subjects | 2348 (100%) | 1824 (100%) | |
Males | 1129 (48.1%) | 839 (46.0%) | 0.181 |
Age <75 years | 2054 (87.5%) | 1314 (72.0%) | <0.001 |
Treatment completed | 1971 (83.9%) | 1438 (78.8%) | <0.001 |
Any adverse event leading to permanent discontinuation of treatment | 281 (12.0%) | 172 (9.4%) | 0.009 |
Hepatotoxicity leading to permanent discontinuation of treatment | 18 (0.8%) | 35 (1.9%) | 0.001 |