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The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration

Leo Heunks, Giacomo Bellani, Tài Pham, Laurent Brochard, John G. Laffey
European Respiratory Journal 2019 53: 1802228; DOI: 10.1183/13993003.02228-2018
Leo Heunks
1Dept of Intensive Care Medicine, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands
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Giacomo Bellani
2School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
3Dept of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy
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Tài Pham
4Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, ON, Canada
5Dept of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada
6Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
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Laurent Brochard
4Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, ON, Canada
5Dept of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada
6Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
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John G. Laffey
4Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, ON, Canada
7Anaesthesia, School of Medicine, National University of Ireland Galway, Galway, Ireland
8Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, National University of Ireland Galway, Galway, Ireland
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  • ORCID record for John G. Laffey
  • For correspondence: john.laffey@nuigalway.ie
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    FIGURE 1

    a) Participating intensive care units (ICUs) in the worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) prospective cohort study, by country. b) Patients enrolled in the WEAN SAFE prospective cohort study, by country.

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  • TABLE 1

    Unanswered questions to be addressed by the worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) study

    1What is the frequency of delayed weaning from IMV?
    2What current approaches are taken to wean patients from IMV?
    3What factors are used to determine when patients are in the weaning phase?
    4What are the barriers to effective weaning from IMV?
    5What are the factors (patient, institutional, medical practice) that contribute to failed attempts to wean from IMV?
    6What is the impact of sedation management on weaning from IMV?
    7What is the impact of pre-morbid conditions and of frailty on weaning from IMV?
    8What is the utility of existing classifications for weaning from IMV?
    9What is the impact of early versus delayed and/or failed weaning from IMV?
    10What is the role of noninvasive ventilation in the weaning process?
    11What regional or geo-economic differences exist regarding weaning from IMV?
    12What is the therapeutic resource use in patients with delayed weaning from IMV?

    IMV: invasive mechanical ventilation.

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    The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration
    Leo Heunks, Giacomo Bellani, Tài Pham, Laurent Brochard, John G. Laffey
    European Respiratory Journal Mar 2019, 53 (3) 1802228; DOI: 10.1183/13993003.02228-2018

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    The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration
    Leo Heunks, Giacomo Bellani, Tài Pham, Laurent Brochard, John G. Laffey
    European Respiratory Journal Mar 2019, 53 (3) 1802228; DOI: 10.1183/13993003.02228-2018
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