Extract
The diagnosis of pulmonary tuberculosis (pTB) in young children often relies on clinical diagnosis because young children are usually unable to produce a sputum sample. Sputum induction or gastric aspiration can be applied to obtain a sample for microbiological diagnosis but these methods cause discomfort, stress and pain, and cannot be performed at the lowest levels of the healthcare system, thus limiting access to pTB diagnosis of children.
Abstract
A simple processing method for stool with Xpert MTB/RIF yields reliable results for young children, thus providing opportunity for painless bacteriological diagnosis of TB in children at the lowest healthcare levels. http://ow.ly/8CEI30nb0He
Acknowledgements
Heda Melinda Nataprawira (Pediatric Respirology Division, Dept of Child Health, Hasan Sadikin General Hospital and Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonedia) is thanked for recruiting children, and Ida Parwati (Dept of Clinical Pathology, Hasan Sadikin General Hospital and Faculty of Medicine, Universitas Padjadjaran) for her supervision and support of the laboratory work for this project.
Footnotes
Conflict of interest: B. Andriyoko has nothing to disclose.
Conflict of interest: H. Janiar has nothing to disclose.
Conflict of interest: R. Kusumadewi has nothing to disclose.
Conflict of interest: E. Klinkenberg has nothing to disclose.
Conflict of interest: P. de Haas has nothing to disclose.
Conflict of interest: E. Tiemersma has nothing to disclose.
Support statement: This work was partly funded by US Agency for International Development (USAID) through Challenge TB under the terms of Agreement No. AID-OAA-A-14-00029. The contents are the responsibility of the authors and do not necessarily reflect the views of USAID or the US Government. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received October 5, 2018.
- Accepted November 24, 2018.
- The content of this work is copyright of the authors or their employers. Design and branding are copyright ©ERS 2019
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