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Early experience of oxygen enhanced magnetic resonance imaging (OE-MRI) in ataxia telangiectasia (A-T)

Andrew Prayle, Marta Tibiletti, Caroline Youle, Shahideh Safavi, Saleh Alenazi, Jan Alappadan Paul, Andrew Cooper, Brett Haywood, Michael Barlow, Rob Dineen, Matthew Hurley, Geoff J M Parker, Andrew Bush, Ian Hall, Jayesh Bhatt
European Respiratory Journal 2018 52: PA3888; DOI: 10.1183/13993003.congress-2018.PA3888
Andrew Prayle
1The University of Nottingham, Nottingham, United Kingdom
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Marta Tibiletti
2Bioxydyn Ltd. , Manchester, United Kingdom
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Caroline Youle
3Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
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Shahideh Safavi
1The University of Nottingham, Nottingham, United Kingdom
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Saleh Alenazi
1The University of Nottingham, Nottingham, United Kingdom
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Jan Alappadan Paul
1The University of Nottingham, Nottingham, United Kingdom
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Andrew Cooper
1The University of Nottingham, Nottingham, United Kingdom
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Brett Haywood
1The University of Nottingham, Nottingham, United Kingdom
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Michael Barlow
1The University of Nottingham, Nottingham, United Kingdom
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Rob Dineen
1The University of Nottingham, Nottingham, United Kingdom
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Matthew Hurley
1The University of Nottingham, Nottingham, United Kingdom
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Geoff J M Parker
2Bioxydyn Ltd. , Manchester, United Kingdom
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Andrew Bush
4Imperial College London, London, United Kingdom
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Ian Hall
1The University of Nottingham, Nottingham, United Kingdom
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Jayesh Bhatt
3Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
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Abstract

Ataxia-Telangiectasia (A-T) is characterised by progressive ataxia, immunodeficiency, malignancy and chronic lung infection. Respiratory disease and cancer are leading causes of death. Imaging the lungs is challenging due to sensitivity to ionising radiation.

Dynamic oxygen enhanced MRI (OE-MRI) characterises the arrival of oxygen into lung tissue by monitoring changes in MR signal on hyperoxia. No breath-hold is required. OEMRI has not previously been used in A-T.

Aims: We aimed to assess the feasibility of undertaking OE-MRI in A-T. We hypothesized that children with A-T would be able to successfully complete an OE-MRI protocol.

Methods: We studied children and young people with A-T. Participants have been enrolled to a 3 year cohort study. OE-MRI was done in a 1.5T GE systems machine, with image analysis with the Pulmolux (Bioxydyn, Ltd) platform.

Results: We present early results from the first 5 participants (aged 9 – 15). All children undertook the OE-MRI protocol without sedation. Patient experience feedback from the scans has been positive. The median signal enhancement due to O2 breathing was 15%. Heterogeneity of oxygen delivery was observed, suggestive of ventilation variability.

Conclusions: OE-MRI is feasible in children with A-T without sedation. Work is ongoing to understand OE-MRI reproducibility and role in A-T.

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Fig: Overlay of O2 enhancement map [%] over anatomical images.

Footnotes

Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA3888.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2018
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Early experience of oxygen enhanced magnetic resonance imaging (OE-MRI) in ataxia telangiectasia (A-T)
Andrew Prayle, Marta Tibiletti, Caroline Youle, Shahideh Safavi, Saleh Alenazi, Jan Alappadan Paul, Andrew Cooper, Brett Haywood, Michael Barlow, Rob Dineen, Matthew Hurley, Geoff J M Parker, Andrew Bush, Ian Hall, Jayesh Bhatt
European Respiratory Journal Sep 2018, 52 (suppl 62) PA3888; DOI: 10.1183/13993003.congress-2018.PA3888

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Early experience of oxygen enhanced magnetic resonance imaging (OE-MRI) in ataxia telangiectasia (A-T)
Andrew Prayle, Marta Tibiletti, Caroline Youle, Shahideh Safavi, Saleh Alenazi, Jan Alappadan Paul, Andrew Cooper, Brett Haywood, Michael Barlow, Rob Dineen, Matthew Hurley, Geoff J M Parker, Andrew Bush, Ian Hall, Jayesh Bhatt
European Respiratory Journal Sep 2018, 52 (suppl 62) PA3888; DOI: 10.1183/13993003.congress-2018.PA3888
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