Vitamin-D deficiency & anaemia in patients with acute exacerbations of COPD (AECOPD); morbidity & mortality.

Abstract

Aims of study: To determine prevalence of Vitamin D deficiency & anaemia in patients admitted to hospital with acute exacerbations of COPD (AECOPD); morbidity & mortality.

Methods: Retrospective study; patients admitted to hospital with acute exacberation of COPD (AECOPD). Data included: COPD severity (GOLD), admission frequency, presence of osteoporosis, walking distance (WD), laboratory values including vitamin D (VitD).

Results: 125 patients, 63% female; age 73.5 (10.9)y. GOLD stage (III 27 %; IV 57 %); long-term oxygen (LTOT) 38%; chronic type 2 respiratory failure (T2RF) 56.8%. Median number of admissions/y for AECOPD 3 (0-13); Non-invasive ventilation (NIV) given in 24%. Prevalence of VitD deficiency (50% tested) 80.3%; osteoporosis 34.4%; anaemia 43.5%.

Multiple admissions ( >4/y) if VitD deficient: Odd ratio (OR 95% CI) 2.2 (1.02-4.8). Overall Mortality 17.6% (F 21.5% v 10.8% NS). Variables associated with mortality: VitD deficiency, osteoporosis, anaemia (Table 1). Combined VitD deficiency & anaemia had mortality 46.1% v 10.1% (p<0.001).

Conclusion: 1. High Prevalence of Vitamin D deficiency & anaemia in severe COPD

2. Vitamin D deficiency associated with frequent admissions for COPD

3. Vitamin D deficiency & anaemia associated with high mortality in COPD