Abstract
Introduction: Pulmonary Mycobacterium avium complex (pMAC) disease is typically chronic and gradually progressive. However, little is known about the clinical impact of the six-minute walk test (6MWT) in pMAC disease.
Aims: This study aimed to investigate the relationship between the 6MWT parameters and clinical factors including health-related quality of life (HRQL).
Methods: A cross-sectional study was conducted at Keio University Hospital to investigate the relationship between the results of the 6MWT and clinical parameters, including HRQL. Adult pMAC patients were enrolled, and HRQL was assessed by the 36-item short form health survey version 2 (SF-36) and St. George’s Respiratory Questionnaire (SGRQ).
Results: A total of 103 consecutive pMAC patients performed the 6MWT and answered the HRQL questionnaires (median age, 64 years; 80 females). Among the 6MWT parameters, the 6MWD was significantly negatively correlated with all SGRQ components (ρ = -0.54−-0.32) and positively correlated with the physical component summary (PCS) (ρ = 0.39) in the SF-36. The final Borg scale (FBS) was significantly positively correlated with all SGRQ components (ρ = 0.34−0.58) and negatively correlated with PCS (ρ = -0.50) in the SF-36. The distance-saturation product was significantly negatively correlated with all SGRQ components (ρ = -0.29−-0.55) and positively correlated with PCS (ρ = 0.40) in the SF-36. Regarding the multivariable analyses, the 6MWD and FBS significantly predicted the impact and total scores in the SGRQ and the PCS score in the SF-36.
Conclusions: The 6MWD and FBS in the 6MWT are useful parameters for evaluating the HRQL status of patients with pMAC disease.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA355.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018