Abstract
Background: There are strong evidences demonstrating that there is a sympathetic dominance in pulmonary diseases. Although in clinical practice the increase in sympathetic modulation is an indicator of cardiovascular risk and sudden death, in lung diseases this dominance may improve the ability of oxygen uptake.
Objective: to compare the autonomic modulation in patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease, both with respiratory impairment.
Methods: This is a cross-sectional study that evaluated the Autonomic Nervous System participation by spectral analysis of heart rate variability.
Results: Our data (table) demonstrated that patients with interstitial lung disease, but not with COPD, had a dominance of sympathetic modulation. In patients with COPD, the LF/HF ratio was 500% lower and the HRV was significantly higher.
Conclusions: The sympathetic dominance seen in the interstitial lung disease is mainly due to withdrawal from parasympathetic modulation. Ultimately, this dominance might facilitate the ventilation/perfusion matching and improve the oxygen uptake in those patients. Further studies are necessary to confirm these findings.
The spectral analysis comparison between diseases HRV= heart rate variability; LF= low-frequency and HF= high-frequency components; ms2= absolute units; nu=%. The Student's t-test compared groups. P=0.03#; P=0.01*; P=0.001**
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2979.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018
