Abstract
Introduction: Chronic hypersensitivity pneumonitis (CHP) is an interstitial lung disease with scarse treatment response and bad prognosis. Sometimes it is indistinguishable from idiopathic pulmonary fibrosis (IPF), being one of the main differential diagnoses. The aim of this study was to compare survival and pulmonary functional decline (PFD) between these two entities
Methods: retrospective study. Survival and time to PFD of more than 10% in FVC was compared using Kaplan Meier (KM) method between patients with CHP and IPF. Cox proportional hazard analysis was used to identify independent predictors of survival and PFD.
Results: 146 patients were included, 54 with CHP and 92 with IPF. KM estimate for 2 years survival was 0,71 (CI 95% 0,6 – 0,8) for CHP group and 0,83 (CI 95% 0,66 – 0,92) for IPF (p= 0,027). Nevertheless this difference disappeared using Cox proportional hazard analysis; the adjusted HR for CHP diagnosis was 0,53 (CI 95% 0,25 -1,15) (p= 0,11). There was no difference in functional evolution in the two groups. KM estimate for a PFD of more or equal than 10% in FVC was 0,64 for CHP (CI 95% 0,43 – 0,79) and 0,78 for IPF (IC 95% 0,6 – 0,88) (p= 0,22). This observation did not change after performing Cox proportional hazard analysis.
Conclusions: This study shows that both IPF and CHP are fibrosing interstitial diseases with a similar evolution and survival. Taking this into consideration, therapeutic approach might need to change among patients with CHP.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2969.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018