Abstract
Body: Tissue inhibitor of metalloproteinase (TIMP) family are associated with the inhibition of matrix metalloproteinase (MMP), which contributes to the degradation of extracellular matrix (ECM) for tissue remodeling, cancer cell invasion and metastasis. However only few studies reported the implication of single nucleotide polymorphisms (SNPs) of TIMP-2 and -3 in clinical significance of non-small cell lung cancer. In this study, the association of genotypic polymorphisms in TIMP-2 and -3 with NSCLC was investigated. 688 patients with NSCLC and 692 healthy controls recruited from the China Medical Hospital in Taiwan were genotyped by a PCR-RFLP method.
Results: Overall, the distribution of the genotype frequencies of TIMP-2 303 T>C, TIMP-2 418 C>G and TIMP-3 249T>C were significantly different between the lung cancer patients and the healthy controls, and also different between patients with lung cancers of various stages. Logistic regression analysis revealed that higher odds ratios (ORs) for lung cancer were seen for individuals with TIMP-2 C303T TT genotype against CC/CT genotypes, TIMP-2 G418C CC genotype against GG/GC genotypes, TIMP-3 C249T TT genotype against CC/CT genotypes. The patients carrying a homozygous TT genotype at TIMP-2 C303T, a homozygous CC genotype at TIMP-2 G418C, or a homozygous TT genotype at TIMP-3 C249T had a tendency to advanced disease.
Conclusions: A significant association between the TIMP-2 C303T, G418C and TIMP-3 C249T genetic polymorphisms and the susceptibility to NSCLC was demonstrated. Also, these polymorphisms were associated with the severity of non-small cell lung cancer.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2791.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
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