Abstract
Introduction: Although many prognostic factors are examined in non-small cell lung cancer (NSCLC), new marlers are needed to predict disease progression. It has recently been suggested that a high neutrophil/lymphocyte ratio (NLR) is a marker of cancer prognosis.
Objective: In this study, we aimed to determine the prognostic value of NLR just before treatment in NSCLC and to determine the correlation with other clinical prognostic factors.
Material-Method: The medical records of the patients who were examined and treated between 2009 and 2013 at the thoracic oncology unit of Gazi University Faculty of Medicine were examined retrospectively. Demographic, clinical and pathological data were recorded. NLR values before treatment were determined. NLR <4, NLR<5, NLR<7, NLR<10, age, sex, smoking, histopathology, Eastern Cooperative Oncology Goup (ECOG) performance score, stage, albumin, lactate dehydrogenase (LDH), surgery, chemotherapy intake and one-year, two-year and overall survival were examined.
Results: A total of 121 patients with a median age of 61.9 (range 34-84), 14 (11.6%) female, and 107 (88.4%) were included in the study. In univariate analysis, stage (p<0.001), ECOG performance score (p<0.001), surgery (p<0.001) and NLR<2 (P=0.043) were the prognostic factors. In multivariate analysis, NLR<2 was not determined as an independent risk factor (p>0.05). Early stage (stage 1-2), ECOG (0-1) and surgery were independent prognostic factors (p<0.001). Kaplan Meier analysis showed that the survival time of the group with NLR>10 was shorter (p=0.046).
Conclusion: Although not independent prognostic factor, increase of NLR was related to shorting of survival of NSCLC.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2785.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018