Abstract
MMPs play an important role in the turnover of almost all extracellular matrix molecules and are probably involved in PT and COPD pathogenesis.
The goal is to evaluate the relationship between MMPs and lung function in PT patients with cavities and with/without comorbid COPD.
Methods: PT patients with a verified diagnosis were divided into 2 groups: I gr. (n=37) with and II gr. (n=123) without COPD. MMP-1,-8,-9 and TIMP-1 serum concentrations were measured by ELISA. Spirometry, bodyplethismography and investigation of diffusion capacity (DLCO) were performed by MasterScreen-Body/Diff.
Results: ММР-1,-8,-9 were increased (р≤0,05) in both gr., TIMP-1 did not change (р>0,05) in comparison with control. In both gr. MMP-8,-9 were associated with RV/TLC (r=0,28, p<0,04; r=0,43, p<0,004). In I gr.: MMP-1 was associated with FEV1 and airway reversibility (r=-0,43, p< 0,05); MMP-8 - with FVC (r=-0,64, p<0,03), Raw (r=0,63, p<0,03); MMP-9 - with FEV1/FVC (r=-0,63, p<0,004), DLCO (r= -0,66, p<0,002); TIMP-1 - with FVC (r=-0,44, p<0,03), Raw (r=0,47, p<0,02), FRC (r=-0,49, p< 0,02), airtrapping volume (r=0,41, p<0,05). In II gr.: ММР-8 was associated with DLCO (r=-0,51, p<0,01).
Conclusions: It was shown, that markers of tissue turnover are significantly associated with lung function change. PT regardless of the COPD is characterized by imbalance ММР/TIMP-1 and increase in MMP-8, -9 is associated with signs of hyperinflation. DLCO for patients with COPD was correlated with MMP-9, but for group without it with MMP-8. In the case of COPD patients MMP-1,-8,-9, TIMP-1 were associated with airway obstruction, also MMP-1 was correlated with bronchodilator response.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2717.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018