Extract
Recently, positron emission tomography (PET)–computed tomography (CT) imaging in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake both in fibrotic lung and areas of lung with a normal radiological appearance on high-resolution computed tomography (HRCT) [1, 2]. IPF is characterised by heterogeneous fibrosis at the tissue level, so to gain insight into the early “microscopic” disease process we used established textural features [3, 4] to evaluate heterogeneity of [18F]-FDG uptake in radiologically normal lung in patients with IPF.
Abstract
Textural analysis demonstrates increased heterogeneity of [18F]-FDG uptake in normal lung (on CT) in patients with IPF. Molecular imaging of the lungs using PET can be used to study early disease in IPF before CT abnormalities are apparent. http://ow.ly/T82W30lGU0X
Footnotes
Conflict of interest: S.A. Aliyu has nothing to disclose.
Conflict of interest: G. Avery has nothing to disclose.
Conflict of interest: C. Cawthorne has nothing to disclose.
Conflict of interest: S.J. Archibald has nothing to disclose.
Conflict of interest: T. Kadir is an employee and shareholder of Mirada Medical, and an employee, director and shareholder of Optellum Ltd.
Conflict of interest: J.M.Y. Willaime is an employee of Mirada Medical.
Conflict of interest: A.H. Morice has nothing to disclose.
Conflict of interest: S.P. Hart has nothing to disclose.
Conflict of interest: M.G. Crooks has nothing to disclose.
- Received July 3, 2018.
- Accepted August 24, 2018.
- Copyright ©ERS 2018
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