Abstract
Pre-eclampsia is associated with an increased risk of bronchopulmonary dysplasia, wheezing and asthma in later childhood. Currently, there are no studies available investigating maternal blood pressure measurements during multiple time-points in pregnancy and respiratory outcome measures in the child.
We examined the associations of maternal blood pressure and hypertensive disorders with the risk of lower lung function, wheezing and asthma in children aged 10 years. This study among 4894 children was embedded in a population-based prospective cohort study. We used multivariate analyses, taking lifestyle and socioeconomic factors into account.
We observed consistent associations per 5 mmHg higher maternal blood pressure in early pregnancy with a lower forced expiratory volume in 1 s/forced vital capacity ratio (z-score −0.03 (95% CI −0.05– −0.01)) and per 5 mmHg higher blood pressure in late pregnancy with a higher risk for current wheezing and current asthma (OR 1.07 (95% CI 1.02–1.12) and 1.06 (95% CI 1.00–1.11), respectively). We found no associations of maternal hypertensive disorders during pregnancy with child lung function, current wheezing or current asthma.
Our results suggest that higher blood pressure in pregnant women is associated with lower lung function and increased risks of current wheezing and current asthma in children. The associations may be trimester specific.
Abstract
Higher blood pressure in pregnant women is associated with lower lung function, wheezing and asthma in children http://ow.ly/R9MI30m92GM
Footnotes
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Author contributions: F.A. Wilmink, H.T. den Dekker and L. Duijts contributed to the conception and design, acquisition of data, analyses and interpretation of the data, drafted the article, revised it critically for important intellectual content, and gave final approval of the version to be published. J.C. de Jongste, I.K.M. Reiss, V.W.V. Jaddoe and E.A. Steegers contributed to the conception and design, acquisition of data, revised the drafted manuscript critically for important intellectual content, and gave final approval of the version to be published.
Conflict of interest: F.A. Wilmink has nothing to disclose.
Conflict of interest: H.T. den Dekker has nothing to disclose.
Conflict of interest: J.C. de Jongste has nothing to disclose.
Conflict of interest: I.K.M. Reiss has nothing to disclose.
Conflict of interest: V.W.V. Jaddoe has nothing to disclose.
Conflict of interest: E.A. Steegers has nothing to disclose.
Conflict of interest: L. Duijts reports grants from the European Union's Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), and from the European Union's Horizon 2020 research and innovation programme, during the conduct of the study.
Support statement: The Generation R Study is made possible by financial support from the Erasmus MC, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data or writing of this report. V.W.V. Jaddoe received an additional grant from the Netherlands Organization for Health Research and Development (ZonMw-VIDI). L. Duijts received funding from the European Union's Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) (ALPHABET project 696295, 2017; ZonMW 529051014, 2017). The project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE project 733206, 2016). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received February 22, 2018.
- Accepted September 29, 2018.
- Copyright ©ERS 2018
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