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Table of Contents

01 November 2018; volume 52, issue 5

Editorials

  • You have accessRestricted access
    The European Respiratory Society's 10 Principles for Lung Health
    Ildikó Horváth, Maeve Barry, Guy Brusselle, Otto Chris Burghuber, Andrew Bush, Carlos Robalo Cordeiro, Mina Gaga, Christina Gratziou, Isabel Saraiva, Daiana Stolz, Thierry Troosters, Tobias Welte, Giovanni Battista Migliori, Guy Joos
    European Respiratory Journal 52 (5) 1801373; DOI: 10.1183/13993003.01373-2018 Published 29 November 2018
  • You have accessRestricted access
    The Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) ERS Clinical Research Collaboration: a new dawn in asthma research
    Ratko Djukanovic, Ian M. Adcock, Gary Anderson, Elisabeth H. Bel, Giorgio W. Canonica, Hui Cao, Kian Fan Chung, Donna E. Davies, Céline Genton, Toni Gibson-Latimer, Dominique Hamerlijnck, Elise Heuvelin, Renaud Louis, Stephanie Korn, Maxim Kots, Namhee Kwon, Riad Naddaf, Scott S. Wagers on behalf of the SHARP Clinical Research Collaboration
    European Respiratory Journal 52 (5) 1801671; DOI: 10.1183/13993003.01671-2018 Published 29 November 2018
  • You have accessRestricted access
    The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) ERS Clinical Research Collaboration
    Stefano Aliberti, Eva Polverino, James D. Chalmers, Josje Altenburg, Michal Shteinberg, Pieter C. Goeminne, Tobias Welte, Amelia Shoemark, Marta Almagro, Francesco Blasi on behalf of the EMBARC Clinical Research Collaboration
    European Respiratory Journal 52 (5) 1802074; DOI: 10.1183/13993003.02074-2018 Published 29 November 2018
  • You have accessRestricted access
    Pirfenidone in the kaleidoscope: reflecting mechanisms through different angles
    Argyris Tzouvelekis, Paul J. Wolters
    European Respiratory Journal 52 (5) 1802046; DOI: 10.1183/13993003.02046-2018 Published 22 November 2018
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    An inhaled “bifunctional” dual PDE3/4 inhibitor provides additional short-term improvements in lung function compared to existing classes of bronchodilator: implications for future treatment of COPD
    Mario Cazzola, Clive Page
    European Respiratory Journal 52 (5) 1801675; DOI: 10.1183/13993003.01675-2018 Published 1 November 2018
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    The further paradoxes of asthma management: time for a new approach across the spectrum of asthma severity
    Richard Beasley, Grace Bird, James Harper, Mark Weatherall
    European Respiratory Journal 52 (5) 1800694; DOI: 10.1183/13993003.00694-2018 Published 1 November 2018
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    Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis
    Heng-Jia Liu, Elizabeth P. Henske
    European Respiratory Journal 52 (5) 1801886; DOI: 10.1183/13993003.01886-2018 Published 1 November 2018
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    Happy ever after? A new assessment tool for long-term noninvasive ventilation: the S3-NIV questionnaire
    Anita K. Simonds
    European Respiratory Journal 52 (5) 1801969; DOI: 10.1183/13993003.01969-2018 Published 22 November 2018

ERS Official Documents

  • ERS technical standards

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      ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing
      Teal S. Hallstrand, Joerg D. Leuppi, Guy Joos, Graham L. Hall, Kai-Håkon Carlsen, David A. Kaminsky, Allan L. Coates, Donald W. Cockcroft, Bruce H. Culver, Zuzana Diamant, Gail M. Gauvreau, Ildiko Horvath, Frans H.C. de Jongh, Beth L. Laube, Peter J. Sterk, Jack Wanger the American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force
      European Respiratory Journal 52 (5) 1801033; DOI: 10.1183/13993003.01033-2018 Published 15 November 2018

Perspective

  • Open Access
    Evaluating the potential costs and impact of digital health technologies for tuberculosis treatment support
    Ntwali Placide Nsengiyumva, Benjamin Mappin-Kasirer, Olivia Oxlade, Mayara Bastos, Anete Trajman, Dennis Falzon, Kevin Schwartzman
    European Respiratory Journal 52 (5) 1801363; DOI: 10.1183/13993003.01363-2018 Published 1 November 2018

Original Articles

  • Paediatrics

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      Maternal blood pressure and hypertensive disorders during pregnancy and childhood respiratory morbidity: the Generation R Study
      Freke A. Wilmink, Herman T. den Dekker, Johan C. de Jongste, Irwin K.M. Reiss, Vincent W.V. Jaddoe, Eric A. Steegers, Liesbeth Duijts
      European Respiratory Journal 52 (5) 1800378; DOI: 10.1183/13993003.00378-2018 Published 29 November 2018
  • Asthma

    • Open Access
      Matching-adjusted indirect comparison of benralizumab versus interleukin-5 inhibitors for the treatment of severe asthma: a systematic review
      Arnaud Bourdin, Don Husereau, Nicolas Molinari, Sarowar Golam, Mohd Kashif Siddiqui, Leandro Lindner, Xiao Xu
      European Respiratory Journal 52 (5) 1801393; DOI: 10.1183/13993003.01393-2018 Published 29 November 2018
  • Interstitial lung diseases

    • Open Access
      Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis
      Grazyna Kwapiszewska, Anna Gungl, Jochen Wilhelm, Leigh M. Marsh, Helene Thekkekara Puthenparampil, Katharina Sinn, Miroslava Didiasova, Walter Klepetko, Djuro Kosanovic, Ralph T. Schermuly, Lukasz Wujak, Benjamin Weiss, Liliana Schaefer, Marc Schneider, Michael Kreuter, Andrea Olschewski, Werner Seeger, Horst Olschewski, Malgorzata Wygrecka
      European Respiratory Journal 52 (5) 1800564; DOI: 10.1183/13993003.00564-2018 Published 22 November 2018
  • Pleural disease

    • You have accessRestricted access
      Investigating unilateral pleural effusions: the role of cytology
      David T. Arnold, Duneesha De Fonseka, Siobhan Perry, Anna Morley, John E. Harvey, Andrew Medford, Mary Brett, Nick A. Maskell
      European Respiratory Journal 52 (5) 1801254; DOI: 10.1183/13993003.01254-2018 Published 8 November 2018
  • Cystic fibrosis and imaging

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      Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout
      Laurie J. Smith, Guilhem J. Collier, Helen Marshall, Paul J.C. Hughes, Alberto M. Biancardi, Martin Wildman, Ina Aldag, Noreen West, Alex Horsley, Jim M. Wild
      European Respiratory Journal 52 (5) 1800821; DOI: 10.1183/13993003.00821-2018 Published 8 November 2018
  • Pulmonary vascular diseases

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      Fibrinogen and the prediction of residual obstruction manifested after pulmonary embolism treatment
      Benjamin Planquette, Olivier Sanchez, James J. Marsh, Peter G. Chiles, Joseph Emmerich, Grégoire Le Gal, Guy Meyer, Tanya Wolfson, Anthony C. Gamst, Roger E. Moore, Gabriel B. Gugiu, Timothy A. Morris
      European Respiratory Journal 52 (5) 1801467; DOI: 10.1183/13993003.01467-2018 Published 15 November 2018
    • You have accessRestricted access
      Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients
      Marion Delcroix, Gerd Staehler, Henning Gall, Ekkehard Grünig, Matthias Held, Michael Halank, Hans Klose, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Joanna Pepke-Zaba, Christian F. Opitz, J. Simon R. Gibbs, Tobias J. Lange, Iraklis Tsangaris, Doerte Huscher, David Pittrow, Karen M. Olsson, Marius M. Hoeper
      European Respiratory Journal 52 (5) 1800248; DOI: 10.1183/13993003.00248-2018 Published 8 November 2018
  • Rare lung diseases

    • Open Access
      The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis
      Suzanne Miller, Clare Coveney, Janice Johnson, Aliki-Eleni Farmaki, Nishant Gupta, Martin D. Tobin, Louise V. Wain, Francis X. McCormack, David J. Boocock, Simon R. Johnson
      European Respiratory Journal 52 (5) 1800951; DOI: 10.1183/13993003.00951-2018 Published 1 November 2018
  • COPD

    • Open Access
      The short-term bronchodilator effects of the dual phosphodiesterase 3 and 4 inhibitor RPL554 in COPD
      Dave Singh, Katharine Abbott-Banner, Thomas Bengtsson, Kenneth Newman
      European Respiratory Journal 52 (5) 1801074; DOI: 10.1183/13993003.01074-2018 Published 1 November 2018
  • Sleep and ventilation

    • You have accessRestricted access
      Development and validation of a simple tool for the assessment of home noninvasive ventilation: the S3-NIV questionnaire
      Elise Dupuis-Lozeron, Grégoire Gex, Patrick Pasquina, Pierre-Olivier Bridevaux, Jean-Christian Borel, Paola M. Soccal, Wolfram Windisch, Jean-Louis Pépin, Jean-Paul Janssens, Dan Adler
      European Respiratory Journal 52 (5) 1801182; DOI: 10.1183/13993003.011822018 Published 22 November 2018
  • Sleep

    • You have accessRestricted access
      Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study
      Camila Hirotsu, Jose Haba-Rubio, Sonia M. Togeiro, Pedro Marques-Vidal, Luciano F. Drager, Peter Vollenweider, Gérard Waeber, Lia Bittencourt, Sergio Tufik, Raphael Heinzer
      European Respiratory Journal 52 (5) 1801150; DOI: 10.1183/13993003.01150-2018 Published 8 November 2018
    • You have accessRestricted access
      Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea
      Katia Gagnon, Andrée-Ann Baril, Jacques Montplaisir, Julie Carrier, Sirin Chami, Serge Gauthier, Chantal Lafond, Jean-François Gagnon, Nadia Gosselin
      European Respiratory Journal 52 (5) 1801137; DOI: 10.1183/13993003.01137-2018 Published 1 November 2018

Series

  • You have accessRestricted access
    What is a COPD exacerbation? Current definitions, pitfalls, challenges and opportunities for improvement
    Victor Kim, Shawn D. Aaron
    European Respiratory Journal 52 (5) 1801261; DOI: 10.1183/13993003.01261-2018 Published 15 November 2018
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    COPD biomarkers and phenotypes: opportunities for better outcomes with precision imaging
    George R. Washko, Grace Parraga
    European Respiratory Journal 52 (5) 1801570; DOI: 10.1183/13993003.01570-2018 Published 29 November 2018

Reviews

  • You have accessRestricted access
    Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease
    Konstantinos Gkatzis, Sara Taghizadeh, Dongeun Huh, Didier Y.R. Stainier, Saverio Bellusci
    European Respiratory Journal 52 (5) 1800876; DOI: 10.1183/13993003.00876-2018 Published 29 November 2018
  • Open Access
    Digital technologies and adherence in respiratory diseases: the road ahead
    John D. Blakey, Bruce G. Bender, Alexandra L. Dima, John Weinman, Guilherme Safioti, Richard W. Costello
    European Respiratory Journal 52 (5) 1801147; DOI: 10.1183/13993003.01147-2018 Published 22 November 2018
  • Open Access
    Can we predict tuberculosis cure? What tools are available?
    Delia Goletti, Cecilia S. Lindestam Arlehamn, Thomas J. Scriba, Richard Anthony, Daniela Maria Cirillo, Tonino Alonzi, Claudia M. Denkinger, Frank Cobelens
    European Respiratory Journal 52 (5) 1801089; DOI: 10.1183/13993003.01089-2018 Published 8 November 2018

ERJ Methods

  • You have accessRestricted access
    Whole genome sequencing of Mycobacterium tuberculosis
    Andrea M. Cabibbe, Timothy M. Walker, Stefan Niemann, Daniela M. Cirillo
    European Respiratory Journal 52 (5) 1801163; DOI: 10.1183/13993003.01163-2018 Published 1 November 2018

Agora

  • Research letters

    • Open Access
      Safety of biweekly α1-antitrypsin treatment in the RAPID programme
      Timm Greulich, Jan Chlumsky, Marion Wencker, Oliver Vit, Michael Fries, Thomas Chung, Amgad Shebl, Claus Vogelmeier, Kenneth R. Chapman, Noel G. McElvaney on behalf of the RAPID Trial Group
      European Respiratory Journal 52 (5) 1800897; DOI: 10.1183/13993003.00897-2018 Published 29 November 2018
    • You have accessRestricted access
      Benefits of supervised community physical activity in obstructive sleep apnoea
      Mathieu Berger, Jean-Claude Barthélémy, David Hupin, Jérémy Raffin, Caroline Dupré, Pierre Labeix, Frédéric Costes, Jean-Michel Gaspoz, Frédéric Roche
      European Respiratory Journal 52 (5) 1801592; DOI: 10.1183/13993003.01592-2018 Published 22 November 2018
    • You have accessRestricted access
      Pulmonary function testing is safe in patients with thoracic aortic aneurysms
      Freddy Frost, Rob Peat, Joan McWean, Matt Shaw, Mark Field, Dilip Nazareth, Martin Walshaw
      European Respiratory Journal 52 (5) 1800928; DOI: 10.1183/13993003.00928-2018 Published 15 November 2018
    • You have accessRestricted access
      Systemic oxidative stress in congenital central hypoventilation syndrome
      Donatella Degl'Innocenti, Matteo Becatti, Marta Peruzzi, Claudia Fiorillo, Matteo Ramazzotti, Niccolò Nassi, Cinzia Arzilli, Raffaele Piumelli
      European Respiratory Journal 52 (5) 1801497; DOI: 10.1183/13993003.01497-2018 Published 15 November 2018
    • You have accessRestricted access
      Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis
      Shamsuddeen A. Aliyu, Ged Avery, Christopher Cawthorne, Stephen J. Archibald, Timor Kadir, Julien M.Y. Willaime, Alyn H. Morice, Simon P. Hart, Michael G. Crooks
      European Respiratory Journal 52 (5) 1801138; DOI: 10.1183/13993003.01138-2018 Published 1 November 2018
  • Correspondence

    • You have accessRestricted access
      Statistical compared to clinical significance and the risk of misattribution
      Magnus Ekström, Miriam J. Johnson, David C. Currow
      European Respiratory Journal 52 (5) 1801723; DOI: 10.1183/13993003.01723-2018 Published 29 November 2018
    • You have accessRestricted access
      Statistical compared to clinical significance and the risk of misattribution
      Nicholas T. Vozoris, Peter C. Austin, Paula A. Rochon
      European Respiratory Journal 52 (5) 1801868; DOI: 10.1183/13993003.01868-2018 Published 29 November 2018
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      European Union standard for tuberculosis care on treatment of multidrug-resistant tuberculosis following new World Health Organization recommendations
      Giovanni Battista Migliori, Giovanni Sotgiu, Senia Rosales-Klintz, Marieke J. van der Werf
      European Respiratory Journal 52 (5) 1801617; DOI: 10.1183/13993003.01617-2018 Published 8 November 2018
    • You have accessRestricted access
      Clofazimine does not lead to significant QT interval prolongation: a multicentre study
      Sanne M.H. Zweijpfenning, Hester van Groningen, Jakko van Ingen, Cecile Magis-Escurra, Martin J. Boeree, Dirk Wagner, Hannelore Bax, Claire Andrejak, Reinier Wener, Ananna Rahman, Heinke Kunst, Natalie Lorent, Marc A. Brouwer, Wouter Hoefsloot on behalf of NTM-NET
      European Respiratory Journal 52 (5) 1801386; DOI: 10.1183/13993003.01386-2018 Published 1 November 2018

Author Correction

  • You have accessRestricted access
    “2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung.” Brian L. Graham, Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson and Jack Wanger. Eur Respir J 2017; 49: 1600016.
    European Respiratory Journal 52 (5) 1650016; DOI: 10.1183/13993003.50016-2016 Published 22 November 2018
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European Respiratory Journal: 52 (5)
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