European Respiratory Journal: 52 (5)

01 November 2018; volume 52, issue 5

Editorials

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The European Respiratory Society's 10 Principles for Lung Health
Ildikó Horváth, Maeve Barry, Guy Brusselle, Otto Chris Burghuber, Andrew Bush, Carlos Robalo Cordeiro, Mina Gaga, Christina Gratziou, Isabel Saraiva, Daiana Stolz, Thierry Troosters, Tobias Welte, Giovanni Battista Migliori, Guy Joos

European Respiratory Journal 52 (5) 1801373; DOI: 10.1183/13993003.01373-2018 Published 29 November 2018
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The Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) ERS Clinical Research Collaboration: a new dawn in asthma research
Ratko Djukanovic, Ian M. Adcock, Gary Anderson, Elisabeth H. Bel, Giorgio W. Canonica, Hui Cao, Kian Fan Chung, Donna E. Davies, Céline Genton, Toni Gibson-Latimer, Dominique Hamerlijnck, Elise Heuvelin, Renaud Louis, Stephanie Korn, Maxim Kots, Namhee Kwon, Riad Naddaf, Scott S. Wagers on behalf of the SHARP Clinical Research Collaboration

European Respiratory Journal 52 (5) 1801671; DOI: 10.1183/13993003.01671-2018 Published 29 November 2018
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The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) ERS Clinical Research Collaboration
Stefano Aliberti, Eva Polverino, James D. Chalmers, Josje Altenburg, Michal Shteinberg, Pieter C. Goeminne, Tobias Welte, Amelia Shoemark, Marta Almagro, Francesco Blasi on behalf of the EMBARC Clinical Research Collaboration

European Respiratory Journal 52 (5) 1802074; DOI: 10.1183/13993003.02074-2018 Published 29 November 2018
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Pirfenidone in the kaleidoscope: reflecting mechanisms through different angles
Argyris Tzouvelekis, Paul J. Wolters

European Respiratory Journal 52 (5) 1802046; DOI: 10.1183/13993003.02046-2018 Published 22 November 2018
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An inhaled “bifunctional” dual PDE3/4 inhibitor provides additional short-term improvements in lung function compared to existing classes of bronchodilator: implications for future treatment of COPD
Mario Cazzola, Clive Page

European Respiratory Journal 52 (5) 1801675; DOI: 10.1183/13993003.01675-2018 Published 1 November 2018
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The further paradoxes of asthma management: time for a new approach across the spectrum of asthma severity
Richard Beasley, Grace Bird, James Harper, Mark Weatherall

European Respiratory Journal 52 (5) 1800694; DOI: 10.1183/13993003.00694-2018 Published 1 November 2018
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Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis
Heng-Jia Liu, Elizabeth P. Henske

European Respiratory Journal 52 (5) 1801886; DOI: 10.1183/13993003.01886-2018 Published 1 November 2018
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Happy ever after? A new assessment tool for long-term noninvasive ventilation: the S³-NIV questionnaire
Anita K. Simonds

European Respiratory Journal 52 (5) 1801969; DOI: 10.1183/13993003.01969-2018 Published 22 November 2018

ERS Official Documents

ERS technical standards
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  ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing
  Teal S. Hallstrand, Joerg D. Leuppi, Guy Joos, Graham L. Hall, Kai-Håkon Carlsen, David A. Kaminsky, Allan L. Coates, Donald W. Cockcroft, Bruce H. Culver, Zuzana Diamant, Gail M. Gauvreau, Ildiko Horvath, Frans H.C. de Jongh, Beth L. Laube, Peter J. Sterk, Jack Wanger the American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force
  
  European Respiratory Journal 52 (5) 1801033; DOI: 10.1183/13993003.01033-2018 Published 15 November 2018

Perspective

Open Access
Evaluating the potential costs and impact of digital health technologies for tuberculosis treatment support
Ntwali Placide Nsengiyumva, Benjamin Mappin-Kasirer, Olivia Oxlade, Mayara Bastos, Anete Trajman, Dennis Falzon, Kevin Schwartzman

European Respiratory Journal 52 (5) 1801363; DOI: 10.1183/13993003.01363-2018 Published 1 November 2018

Original Articles

Paediatrics
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  Maternal blood pressure and hypertensive disorders during pregnancy and childhood respiratory morbidity: the Generation R Study
  Freke A. Wilmink, Herman T. den Dekker, Johan C. de Jongste, Irwin K.M. Reiss, Vincent W.V. Jaddoe, Eric A. Steegers, Liesbeth Duijts
  
  European Respiratory Journal 52 (5) 1800378; DOI: 10.1183/13993003.00378-2018 Published 29 November 2018
Asthma
- Open Access
  Matching-adjusted indirect comparison of benralizumab versus interleukin-5 inhibitors for the treatment of severe asthma: a systematic review
  Arnaud Bourdin, Don Husereau, Nicolas Molinari, Sarowar Golam, Mohd Kashif Siddiqui, Leandro Lindner, Xiao Xu
  
  European Respiratory Journal 52 (5) 1801393; DOI: 10.1183/13993003.01393-2018 Published 29 November 2018
Interstitial lung diseases
- Open Access
  Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis
  Grazyna Kwapiszewska, Anna Gungl, Jochen Wilhelm, Leigh M. Marsh, Helene Thekkekara Puthenparampil, Katharina Sinn, Miroslava Didiasova, Walter Klepetko, Djuro Kosanovic, Ralph T. Schermuly, Lukasz Wujak, Benjamin Weiss, Liliana Schaefer, Marc Schneider, Michael Kreuter, Andrea Olschewski, Werner Seeger, Horst Olschewski, Malgorzata Wygrecka
  
  European Respiratory Journal 52 (5) 1800564; DOI: 10.1183/13993003.00564-2018 Published 22 November 2018
Pleural disease
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  Investigating unilateral pleural effusions: the role of cytology
  David T. Arnold, Duneesha De Fonseka, Siobhan Perry, Anna Morley, John E. Harvey, Andrew Medford, Mary Brett, Nick A. Maskell
  
  European Respiratory Journal 52 (5) 1801254; DOI: 10.1183/13993003.01254-2018 Published 8 November 2018
Cystic fibrosis and imaging
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  Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout
  Laurie J. Smith, Guilhem J. Collier, Helen Marshall, Paul J.C. Hughes, Alberto M. Biancardi, Martin Wildman, Ina Aldag, Noreen West, Alex Horsley, Jim M. Wild
  
  European Respiratory Journal 52 (5) 1800821; DOI: 10.1183/13993003.00821-2018 Published 8 November 2018
Pulmonary vascular diseases
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  Fibrinogen and the prediction of residual obstruction manifested after pulmonary embolism treatment
  Benjamin Planquette, Olivier Sanchez, James J. Marsh, Peter G. Chiles, Joseph Emmerich, Grégoire Le Gal, Guy Meyer, Tanya Wolfson, Anthony C. Gamst, Roger E. Moore, Gabriel B. Gugiu, Timothy A. Morris
  
  European Respiratory Journal 52 (5) 1801467; DOI: 10.1183/13993003.01467-2018 Published 15 November 2018
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  Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients
  Marion Delcroix, Gerd Staehler, Henning Gall, Ekkehard Grünig, Matthias Held, Michael Halank, Hans Klose, Anton Vonk-Noordegraaf, Stephan Rosenkranz, Joanna Pepke-Zaba, Christian F. Opitz, J. Simon R. Gibbs, Tobias J. Lange, Iraklis Tsangaris, Doerte Huscher, David Pittrow, Karen M. Olsson, Marius M. Hoeper
  
  European Respiratory Journal 52 (5) 1800248; DOI: 10.1183/13993003.00248-2018 Published 8 November 2018
Rare lung diseases
- Open Access
  The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis
  Suzanne Miller, Clare Coveney, Janice Johnson, Aliki-Eleni Farmaki, Nishant Gupta, Martin D. Tobin, Louise V. Wain, Francis X. McCormack, David J. Boocock, Simon R. Johnson
  
  European Respiratory Journal 52 (5) 1800951; DOI: 10.1183/13993003.00951-2018 Published 1 November 2018
COPD
- Open Access
  The short-term bronchodilator effects of the dual phosphodiesterase 3 and 4 inhibitor RPL554 in COPD
  Dave Singh, Katharine Abbott-Banner, Thomas Bengtsson, Kenneth Newman
  
  European Respiratory Journal 52 (5) 1801074; DOI: 10.1183/13993003.01074-2018 Published 1 November 2018
Sleep and ventilation
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  Development and validation of a simple tool for the assessment of home noninvasive ventilation: the S³-NIV questionnaire
  Elise Dupuis-Lozeron, Grégoire Gex, Patrick Pasquina, Pierre-Olivier Bridevaux, Jean-Christian Borel, Paola M. Soccal, Wolfram Windisch, Jean-Louis Pépin, Jean-Paul Janssens, Dan Adler
  
  European Respiratory Journal 52 (5) 1801182; DOI: 10.1183/13993003.011822018 Published 22 November 2018
Sleep
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  Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study
  Camila Hirotsu, Jose Haba-Rubio, Sonia M. Togeiro, Pedro Marques-Vidal, Luciano F. Drager, Peter Vollenweider, Gérard Waeber, Lia Bittencourt, Sergio Tufik, Raphael Heinzer
  
  European Respiratory Journal 52 (5) 1801150; DOI: 10.1183/13993003.01150-2018 Published 8 November 2018
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  Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea
  Katia Gagnon, Andrée-Ann Baril, Jacques Montplaisir, Julie Carrier, Sirin Chami, Serge Gauthier, Chantal Lafond, Jean-François Gagnon, Nadia Gosselin
  
  European Respiratory Journal 52 (5) 1801137; DOI: 10.1183/13993003.01137-2018 Published 1 November 2018

Series

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What is a COPD exacerbation? Current definitions, pitfalls, challenges and opportunities for improvement
Victor Kim, Shawn D. Aaron

European Respiratory Journal 52 (5) 1801261; DOI: 10.1183/13993003.01261-2018 Published 15 November 2018
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COPD biomarkers and phenotypes: opportunities for better outcomes with precision imaging
George R. Washko, Grace Parraga

European Respiratory Journal 52 (5) 1801570; DOI: 10.1183/13993003.01570-2018 Published 29 November 2018

Reviews

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Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease
Konstantinos Gkatzis, Sara Taghizadeh, Dongeun Huh, Didier Y.R. Stainier, Saverio Bellusci

European Respiratory Journal 52 (5) 1800876; DOI: 10.1183/13993003.00876-2018 Published 29 November 2018
Open Access
Digital technologies and adherence in respiratory diseases: the road ahead
John D. Blakey, Bruce G. Bender, Alexandra L. Dima, John Weinman, Guilherme Safioti, Richard W. Costello

European Respiratory Journal 52 (5) 1801147; DOI: 10.1183/13993003.01147-2018 Published 22 November 2018
Open Access
Can we predict tuberculosis cure? What tools are available?
Delia Goletti, Cecilia S. Lindestam Arlehamn, Thomas J. Scriba, Richard Anthony, Daniela Maria Cirillo, Tonino Alonzi, Claudia M. Denkinger, Frank Cobelens

European Respiratory Journal 52 (5) 1801089; DOI: 10.1183/13993003.01089-2018 Published 8 November 2018

ERJ Methods

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Whole genome sequencing of Mycobacterium tuberculosis
Andrea M. Cabibbe, Timothy M. Walker, Stefan Niemann, Daniela M. Cirillo

European Respiratory Journal 52 (5) 1801163; DOI: 10.1183/13993003.01163-2018 Published 1 November 2018

Agora

Research letters
- Open Access
  Safety of biweekly α₁-antitrypsin treatment in the RAPID programme
  Timm Greulich, Jan Chlumsky, Marion Wencker, Oliver Vit, Michael Fries, Thomas Chung, Amgad Shebl, Claus Vogelmeier, Kenneth R. Chapman, Noel G. McElvaney on behalf of the RAPID Trial Group
  
  European Respiratory Journal 52 (5) 1800897; DOI: 10.1183/13993003.00897-2018 Published 29 November 2018
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  Benefits of supervised community physical activity in obstructive sleep apnoea
  Mathieu Berger, Jean-Claude Barthélémy, David Hupin, Jérémy Raffin, Caroline Dupré, Pierre Labeix, Frédéric Costes, Jean-Michel Gaspoz, Frédéric Roche
  
  European Respiratory Journal 52 (5) 1801592; DOI: 10.1183/13993003.01592-2018 Published 22 November 2018
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  Pulmonary function testing is safe in patients with thoracic aortic aneurysms
  Freddy Frost, Rob Peat, Joan McWean, Matt Shaw, Mark Field, Dilip Nazareth, Martin Walshaw
  
  European Respiratory Journal 52 (5) 1800928; DOI: 10.1183/13993003.00928-2018 Published 15 November 2018
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  Systemic oxidative stress in congenital central hypoventilation syndrome
  Donatella Degl'Innocenti, Matteo Becatti, Marta Peruzzi, Claudia Fiorillo, Matteo Ramazzotti, Niccolò Nassi, Cinzia Arzilli, Raffaele Piumelli
  
  European Respiratory Journal 52 (5) 1801497; DOI: 10.1183/13993003.01497-2018 Published 15 November 2018
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  Textural analysis demonstrates heterogeneous [¹⁸F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis
  Shamsuddeen A. Aliyu, Ged Avery, Christopher Cawthorne, Stephen J. Archibald, Timor Kadir, Julien M.Y. Willaime, Alyn H. Morice, Simon P. Hart, Michael G. Crooks
  
  European Respiratory Journal 52 (5) 1801138; DOI: 10.1183/13993003.01138-2018 Published 1 November 2018
Correspondence
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  Statistical compared to clinical significance and the risk of misattribution
  Magnus Ekström, Miriam J. Johnson, David C. Currow
  
  European Respiratory Journal 52 (5) 1801723; DOI: 10.1183/13993003.01723-2018 Published 29 November 2018
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  Statistical compared to clinical significance and the risk of misattribution
  Nicholas T. Vozoris, Peter C. Austin, Paula A. Rochon
  
  European Respiratory Journal 52 (5) 1801868; DOI: 10.1183/13993003.01868-2018 Published 29 November 2018
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  European Union standard for tuberculosis care on treatment of multidrug-resistant tuberculosis following new World Health Organization recommendations
  Giovanni Battista Migliori, Giovanni Sotgiu, Senia Rosales-Klintz, Marieke J. van der Werf
  
  European Respiratory Journal 52 (5) 1801617; DOI: 10.1183/13993003.01617-2018 Published 8 November 2018
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  Clofazimine does not lead to significant QT interval prolongation: a multicentre study
  Sanne M.H. Zweijpfenning, Hester van Groningen, Jakko van Ingen, Cecile Magis-Escurra, Martin J. Boeree, Dirk Wagner, Hannelore Bax, Claire Andrejak, Reinier Wener, Ananna Rahman, Heinke Kunst, Natalie Lorent, Marc A. Brouwer, Wouter Hoefsloot on behalf of NTM-NET
  
  European Respiratory Journal 52 (5) 1801386; DOI: 10.1183/13993003.01386-2018 Published 1 November 2018

Author Correction

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“2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung.” Brian L. Graham, Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson and Jack Wanger. Eur Respir J 2017; 49: 1600016.
European Respiratory Journal 52 (5) 1650016; DOI: 10.1183/13993003.50016-2016 Published 22 November 2018

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Table of Contents

Editorials

ERS Official Documents

ERS technical standards

Perspective

Original Articles

Paediatrics

Asthma

Interstitial lung diseases

Pleural disease

Cystic fibrosis and imaging

Pulmonary vascular diseases

Rare lung diseases

COPD

Sleep and ventilation

Sleep

Series

Reviews

ERJ Methods

Agora

Research letters

Correspondence

Author Correction

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