Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
  • Alerts
  • Podcasts
  • Subscriptions

Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial

Ane Arbillaga-Etxarri, Elena Gimeno-Santos, Anael Barberan-Garcia, Eva Balcells, Marta Benet, Eulàlia Borrell, Nuria Celorrio, Anna Delgado, Carme Jané, Alicia Marin, Carlos Martín-Cantera, Mónica Monteagudo, Nuria Montellà, Laura Muñoz, Pilar Ortega, Diego A. Rodríguez, Robert Rodríguez-Roisin, Pere Simonet, Pere Torán-Monserrat, Jaume Torrent-Pallicer, Pere Vall-Casas, Jordi Vilaró, Judith Garcia-Aymerich
European Respiratory Journal 2018 52: 1800063; DOI: 10.1183/13993003.00063-2018
Ane Arbillaga-Etxarri
ISGlobal, Barcelona, SpainPompeu Fabra University (UPF), Barcelona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainPhysical Activity and Sports Sciences, Faculty of Psychology and Education, University of Deusto, Donostia-San Sebastián, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ane Arbillaga-Etxarri
Elena Gimeno-Santos
ISGlobal, Barcelona, SpainPompeu Fabra University (UPF), Barcelona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainRespiratory Clinic Institute, Hospital Clinic of Barcelona, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, University of Barcelona, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elena Gimeno-Santos
Anael Barberan-Garcia
Respiratory Clinic Institute, Hospital Clinic of Barcelona, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, University of Barcelona, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anael Barberan-Garcia
Eva Balcells
Pompeu Fabra University (UPF), Barcelona, SpainPneumology Dept, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, SpainCIBER Respiratory Diseases (CIBERES), Bunyola, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marta Benet
ISGlobal, Barcelona, SpainPompeu Fabra University (UPF), Barcelona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Marta Benet
Eulàlia Borrell
Sant Roc Primary Healthcare Centre, Institut Català de la Salut (ICS), Badalona, SpainInstitut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainInstitute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nuria Celorrio
Hospital de Viladecans, Viladecans, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Delgado
ISGlobal, Barcelona, SpainPompeu Fabra University (UPF), Barcelona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carme Jané
Passeig de Sant Joan Primary Healthcare Centre, Institut Català de la Salut (ICS), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alicia Marin
CIBER Respiratory Diseases (CIBERES), Bunyola, SpainPneumology Dept, Hospital Germans Trias i Pujol, Badalona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carlos Martín-Cantera
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainPasseig de Sant Joan Primary Healthcare Centre, Institut Català de la Salut (ICS), Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Carlos Martín-Cantera
Mónica Monteagudo
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mónica Monteagudo
Nuria Montellà
Sant Roc Primary Healthcare Centre, Institut Català de la Salut (ICS), Badalona, SpainInstitut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainInstitute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Muñoz
Agency for Health Quality and Assessment of Catalonia (AQuAS), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pilar Ortega
Pneumology Dept, Hospital de Mataró, Mataró, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Diego A. Rodríguez
Pompeu Fabra University (UPF), Barcelona, SpainPneumology Dept, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, SpainCIBER Respiratory Diseases (CIBERES), Bunyola, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Rodríguez-Roisin
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, University of Barcelona, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pere Simonet
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainViladecans 2 Primary Healthcare Centre, Institut Català de la Salut (ICS), Viladecans, SpainUniversity of Barcelona, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pere Torán-Monserrat
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainInstitute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaume Torrent-Pallicer
ISGlobal, Barcelona, SpainPompeu Fabra University (UPF), Barcelona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pere Vall-Casas
Universitat Internacional de Catalunya (UIC), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jordi Vilaró
FCS Blanquerna, Global Research on Wellbeing (GRoW), Ramon Llull University, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Judith Garcia-Aymerich
ISGlobal, Barcelona, SpainPompeu Fabra University (UPF), Barcelona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Judith Garcia-Aymerich
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

There is a need to increase and maintain physical activity in patients with chronic obstructive pulmonary disease (COPD). We assessed 12-month efficacy and effectiveness of the Urban Training intervention on physical activity in COPD patients.

This randomised controlled trial (NCT01897298) allocated 407 COPD patients from primary and hospital settings 1:1 to usual care (n=205) or Urban Training (n=202). Urban Training consisted of a baseline motivational interview, advice to walk on urban trails designed for COPD patients in outdoor public spaces and other optional components for feedback, motivation, information and support (pedometer, calendar, physical activity brochure, website, phone text messages, walking groups and a phone number). The primary outcome was 12-month change in steps·day−1 measured by accelerometer.

Efficacy analysis (with per-protocol analysis set, n=233 classified as adherent to the assigned intervention) showed adjusted (95% CI) 12-month difference +957 (184–1731) steps·day−1 between Urban Training and usual care. Effectiveness analysis (with intention-to-treat analysis set, n=280 patients completing the study at 12 months including unwilling and self-reported non-adherent patients) showed no differences between groups. Leg muscle pain during walks was more frequently reported in Urban Training than usual care, without differences in any of the other adverse events.

Urban Training, combining behavioural strategies with unsupervised outdoor walking, was efficacious in increasing physical activity after 12 months in COPD patients, with few safety concerns. However, it was ineffective in the full population including unwilling and self-reported non-adherent patients.

Abstract

Urban Training in COPD increased physical activity after 12 months but not in self-reported non-adherent patients http://ow.ly/dc2C30lnAEs

Introduction

Patients with chronic obstructive pulmonary disease (COPD) are substantially less active than their healthy peers [1] and this inactivity has been consistently related to a worse prognosis of the disease [2]. Thus, helping patients to adopt a more active lifestyle is a major goal in COPD management. Unfortunately, how to produce and maintain such behavioural change remains a challenge [3, 4].

Based on the beneficial effects of behavioural strategies on changing physical activity in patients with chronic diseases [5], recent COPD studies have focused on these kinds of interventions. Some of them, including physical activity counselling, pedometers or telecoaching (by computer or mobile technology) have reported increases in physical activity in the short term (≤4 months) [6–8]. However, few studies followed patients for ≥1 year [6, 9–11] and only one of them showed a sustained increase in physical activity, which was limited to a subset of patients [9]. Thus, one of the main difficulties of interventions to modify physical activity in COPD patients the achievement of a more prolonged long-term effect.

Given that currently available interventions are based mostly on patients’ individual factors (biological and psychological), we argue that customising the interventions to patients’ interpersonal (social support and cultural practices) and environmental (social, built and natural) determinants of physical activity [12] could help to maintain the increase in physical activity in the long term. Indeed, a report from the World Health Organization [13] suggests that interventions adapted to the local context and/or using existing social support and community structures are the most successful. In COPD, patients who live with others, walk the dog, take care of grandchildren or have an active partner have higher physical activity levels than those who do not, regardless of COPD severity and other individual characteristics [14–16], which suggests that interpersonal and environmental factors are key factors to include in future interventions.

Based on these premises we designed an intervention (Urban Training) consisting of motivational interviews, availability of outdoor walking trails specifically designed for exercise training of COPD patients [17] and other support components. We hypothesised that Urban Training could encourage COPD patients to increase and maintain their walking activity in the long term, because walking in public spaces is an extended cultural practice well integrated into the daily lifestyle of our COPD patients (elderly inhabitants of Mediterranean cities) [18].

We assessed the efficacy and effectiveness of the Urban Training intervention on physical activity level after 12 months of follow-up in patients with COPD. Secondary outcomes included severe COPD exacerbations, functional exercise capacity, body composition, health-related quality of life, anxiety and depression.

Methods

Study patients

Details on patient recruitment, randomisation and blinding are provided in online supplementary table S1. Briefly, we selected all subjects with a diagnosis of COPD according to the American Thoracic Society/European Respiratory Society recommendations (post-bronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio <0.70) [19] who were seen in any of the participating 33 primary care and five hospital health centres from five Catalan seaside municipalities. We excluded patients with severe or life-threatening comorbidities, or those clinically unstable. The ethics committees of all participating institutions approved the study, along with the request for complete information exemption from patients, and all participants provided written informed consent.

Study design and interventions

This is a prospective, multicentre, parallel-group, randomised controlled trial registered at clinicaltrials.gov (NCT01897298) and reported according to the 2010 CONSORT statement [20] and its extension for non-pharmacological interventions [21]. Patients were allocated 1:1 to the Urban Training intervention or usual-care groups using random block sizes of six, eight and 10. The study consisted of four visits (figure 1): enrolment and baseline data collection; additional baseline data collection, randomisation and intervention 1 week later; 12-month data collection; and additional 12-month data collection 1 week thereafter.

FIGURE 1
  • Download figure
  • Open in new tab
  • Download powerpoint
FIGURE 1

Study visits and assessments. COPD: chronic obstructive pulmonary disease.

Both groups received the usual standardised pharmacological and/or non-pharmacological treatment for COPD, including pulmonary rehabilitation, at the discretion of their physician and without any intervention by the research team.

Patients in the usual-care group were provided with general health counselling and the European Lung Foundation (ELF) information brochure “Living an active life with COPD” [22], which recommends ≥30 min moderate physical activity ≥5 days per week.

The Urban Training intervention consisted of the following six components (figure 2), detailed in the online supplementary material. 1) At baseline, a respiratory physiotherapist adequately trained in behavioural strategies used motivational interviewing techniques [23], integrated with a stage-matched approach [24], for a maximum of 1 h. The interview was centred on empathy, reflective listening and affirmation, and addressed patients' resistance (personal difficulties, barriers and limitations) to eliciting behavioural change. Information on the remaining components of the intervention was provided during this interview. During the follow-up period, the physiotherapist administered up to four phone calls lasting 5–10 min to maintain motivation, depending on patients’ self-efficacy and stage of change. 2) Participants received a dossier containing various maps of Urban Training walking trails, previously validated [17], according to their mobility options and preferences. Concisely, trails of different intensities (low, moderate or high, combining urban elements of varying intensity (stairs, ramps and types of surfacing)) were available in several walkable public spaces (boulevards, beaches and parks) of the five municipalities. The physiotherapist provided a complete explanation of trails characteristics and instructed patients to train following the FITT (frequency, intensity, time and type) principle [25]. Each patient was advised to start with a trail of intensity appropriate to his/her baseline dyspnoea and 6-min walking distance (6MWD), and instructed how to increase progressively the volume (number of walks per day on the same trail) and/or the intensity of the trails during the following 12 months according to their symptoms and motivation (online supplementary figure S1). In all cases, the instructions were to walk at least one trail per day ≥5 days per week, at a pace reaching a dyspnoea Borg scale score of 4–6 [26]. 3) Patients were provided with both a pedometer and a personalised calendar to monitor their physical activity and maintain motivation. 4) Patients received the same ELF information brochure as the usual-care group and the link to the project website (www.entrenament-urba.cat/). They were requested to provide a personal cell phone number where they would receive phone text messages every 2 weeks with educational or motivational messages. 5) Once per month during the follow-up period, patients could join a walking group for walking a trail accompanied by an experienced physical activity trainer. 6) Patients were given a phone number to contact the physiotherapists for any questions during follow-up. Of note, the Urban Training intervention was proposed as a supplement to the physical activities of daily life and in no case as a substitute activity.

FIGURE 2
  • Download figure
  • Open in new tab
  • Download powerpoint
FIGURE 2

Components of the Urban Training intervention.

Procedures

Full details and references on study procedures and quality control are available in the online supplementary material. Briefly, at baseline and 12 months we obtained the following data from all patients using standardised procedures. 1) Sociodemographic variables, smoking status, modified Medical Research Council dyspnoea scale, Clinical COPD Questionnaire (CCQ), COPD Assessment Test (CAT), Hospital Anxiety and Depression (HAD) scale and cognitive impairment (using phototesting) (interviewer-administered questionnaire); 2) 6-min walk test; 3) weight, height, body mass index (BMI) and fat-free mass index (FFMI) (physical examination and bioelectrical impedance); 4) FEV1 and FVC (pre- and post-bronchodilator spirometry); 5) comorbidities, pharmacological therapy and the number and severity of COPD exacerbations in the previous 12 months; 6) physical activity (Dynaport accelerometer; McRoberts BV, The Hague, The Netherlands), previously validated for COPD [27, 28]. A valid physical activity measurement was defined as ≥3 days with ≥8 h of wearing time within waking hours [29]; compliance with the accelerometer was excellent (at baseline all patients fulfilled this criterion, median (range) wear was 7 (3–7) days, and recording time was 14.9 (11.1–15.0) h, of 15 h maximum from 07:00 h to 22:00 h); at the final visit six (2%) out of 286 patients did not fulfil the criterion of wearing time per day and, consequently, were excluded; among included patients, median (range) wear was 7 (4–7) days and recording time was 14.8 (10.2–15) h; all patients included at least one weekend day both at baseline and final visit); and 7) physical activity experience (Clinical-PROactive Physical Activity (C-PPAC)). Additionally, at 12 months, patients answered a questionnaire about satisfaction with the study components and any potential adverse events experienced during or after walks in the previous 12 months. Finally, the physiotherapists administering both interventions noted down patients’ spontaneous report of unwillingness to follow the instructions (e.g. walking ≥5 days per week ≥30 min·day−1 in the usual-care group or walking the Urban Training trails in the Urban Training group) at the baseline visit, as well as spontaneous reports of non-adherence (i.e. not having followed the instructions) at the 12-month visit.

Study outcomes

The primary outcome was the change in number of steps per day from baseline to 12-month follow-up. Secondary outcomes were having any severe COPD exacerbation (leading to hospital or emergency-room admission) during the 12-month follow-up and the 12-month changes in 6MWD, BMI, FFMI, CAT and CCQ total scores, and HAD-anxiety and -depression scores. Exploratory outcomes were the 12-month changes in phototest score, and total, amount and difficulty C-PPAC scores.

Statistical analysis

To detect a difference of 775 steps·day−1 (primary outcome) between groups (based on previous research about the effects of behavioural interventions in the elderly) [30], with a two-sided α=0.05 and a power of 80%, assuming a standard deviation of 3000 steps·day−1 and a correlation between baseline and final steps ≥0.7 (based on authors’ data in COPD patients), a sample size of 142 patients per group was necessary. To account for a 30% dropout rate during follow-up, we planned to recruit 202 participants per group (404 in total).

Prespecified efficacy and effectiveness were analysed using per-protocol and intention-to-treat (ITT) analysis sets, respectively. Briefly, ITT was defined as all randomised patients who completed the study at 12 months and provided a valid record of physical activity, while per-protocol was the subset of ITT who were classified as adherent to their corresponding intervention. Adherence was obtained from the interviews. We classified as “non-adherent” patients who 1) spontaneously reported at baseline that they were unwilling to follow any of the instructions; or 2) spontaneously reported at the 12-month visit that they had not been adherent to the study protocol (see the Procedures section). Remaining patients were labelled as “adherent”. To test effectiveness, we built linear or logistic regression models, using the change from baseline to 12-month follow-up as the outcome, the intervention group as the main exposure variable and baseline levels of the corresponding outcome as a covariate (to account for individual differences in baseline levels). In efficacy analysis, we adjusted additionally for the variables related to adherence, since previous literature has shown that this adjustment may reduce the selection bias produced by a differential distribution of the reasons that moved participants to be adherent [31].

Post hoc analyses included stratification of efficacy results according to subgroups defined by baseline patient characteristics (online supplementary material). All analyses were redone using repeated measures ANOVA instead of linear regression. Safety analysis set included patients answering the adverse events questions at 12 months. All analyses were conducted with Stata 14.0 (StataCorp, College Station, TX, USA).

Results

Between 30 October 2013 and 29 January 2016, 552 stable COPD patients were assessed for eligibility and 407 patients underwent randomisation and received the corresponding intervention (figure 3, online supplementary table S2). 280 patients (69% of the initial study population) completed the final visit and constituted the ITT analysis set (online supplementary table S3). These patients had higher physical activity and functional exercise capacity levels at baseline than those who did not participate in the final visit, both in the usual care and Urban Training group (online supplementary tables S3 and S4). Among followed patients, 233 patients (83% of the ITT) did not report unwillingness or non-adherence to the corresponding intervention and accordingly constituted the per-protocol analysis set. Patients who spontaneously reported unwillingness or non-adherence to the corresponding intervention had lower FEV1/FVC ratio, were most often current smokers, had diabetes in a higher proportion and showed higher values in the HAD-depression score than the rest of the patients (online supplementary table S5).

FIGURE 3
  • Download figure
  • Open in new tab
  • Download powerpoint
FIGURE 3

Flow of participants through the trial. #: at baseline, three patients did not provide a valid record of physical activity due to technical reasons (e.g. patient entered the swimming pool and spoiled the record); ¶: reasons for exclusion between baseline and 12 months were spending >3 months per year away from their home address (n=7), mental disability (n=3), severe comorbidity limiting survival at 1 year (n=13) and another severe comorbidity (n=30); +: at the 12-month visit, six (2%) out of 286 patients did not fulfil the criterion of ≥3 days with ≥8 h of wearing time within waking hours.

Baseline characteristics were similar in the per-protocol and ITT analysis sets and between two intervention groups (tables 1–3). Patients in the per-protocol analysis set were mostly male (88%), mean±sd age 69±8 years, had mild-to-very severe COPD (FEV1 58±17% predicted), preserved functional exercise capacity (6MWD 505±81 m) and walked a mean±sd 8039±3964 steps·day−1.

View this table:
  • View inline
  • View popup
TABLE 1

Baseline characteristics of per-protocol and intention-to-treat analysis sets

View this table:
  • View inline
  • View popup
TABLE 2

Efficacy results (per-protocol analysis set) of Urban Training intervention at 12 months in chronic obstructive pulmonary disease (COPD) patients

View this table:
  • View inline
  • View popup
TABLE 3

Effectiveness results (intention to treat analysis set) of Urban Training intervention at 12 months in chronic obstructive pulmonary disease (COPD) patients

After 12 months, according to the per-protocol analysis set (efficacy analysis), patients in the usual-care group had not changed their physical activity, whereas those in the Urban Training group increased it by 816 steps·day−1 (figure 4 and table 2). In the analysis adjusted by factors independently related to adherence (FEV1/FVC ratio, smoking, diabetes and HAD-depression score; online supplementary table S6) and steps at baseline, the adjusted difference in steps between the Urban Training and usual-care groups was 957 (95% CI 184–1731) steps·day−1 (figure 4 and table 2). There were no differences between intervention groups in any of the secondary outcomes or in cognitive impairment (exploratory outcome) (table 2). Positive changes (statistically significant better values) of physical activity experience were observed in the intervention group for the total, amount and difficulty scores. Stratification of efficacy results showed no significant differences between groups (figure 5). The adjusted difference at 12 months was 959 (−72–1989) steps·day−1 for patients with mild-to-moderate COPD and 383 (−860–1626) steps·day−1 for patients with severe-to-very severe COPD. Patients with higher physical activity levels at baseline had higher increase during follow-up (adjusted difference in steps 1268 (158–2379) steps·day−1 versus 704 (−429–1837) steps·day−1), although there was no sign of statistical interaction.

FIGURE 4
  • Download figure
  • Open in new tab
  • Download powerpoint
FIGURE 4

a) Efficacy and b) effectiveness results of Urban Training intervention on steps per day (primary outcome) at 12 months in chronic obstructive pulmonary disease patients. Data are presented as mean±sem at baseline and 12 months.

FIGURE 5
  • Download figure
  • Open in new tab
  • Download powerpoint
FIGURE 5

Efficacy of Urban Training intervention on steps per day (primary outcome) at 12 months in chronic obstructive pulmonary disease (COPD) patients according to subgroups based on baseline characteristics. Data are presented as adjusted difference (95% CI) at 12 months between intervention and usual-care groups. Subgroups defined by baseline airflow limitation stages (mild to moderate versus severe to very severe), functional exercise capacity (median 6-min walking distance (6MWD) <500 versus ≥500 m), comorbidity (Charlson index <2 versus ≥2) and physical activity levels (baseline <7100 versus ≥7100 steps per day, cut-off equivalent to being adherent to physical activity recommendations for older adults) [30].

After 12 months, in the ITT analysis set (effectiveness analysis), there were no differences between intervention groups in any of the primary, secondary or exploratory outcomes (figure 4 and table 3). Analyses with repeated measures ANOVA provided very similar results.

Patients in the Urban Training group reported higher frequency of lower extremity muscle pain during walks than patients in the usual care group (38 versus 25%, p=0.031) without differences in any of the remaining adverse events (table 4).

View this table:
  • View inline
  • View popup
TABLE 4

Adverse events during or after walks in the safety analysis set

Of the 132 patients of the intervention group participating in the follow-up visit, 70%, 87% and 90% used the trails maps, calendars and pedometers, respectively; 31% participated at least once in the walking groups; 41% contacted the researchers via phone during follow-up; and 2% visited the study website. At the 12-month visit, 65% of patients delivered the calendars, and the mean±sd fulfilled months was 9±4 months. Satisfaction with the study and study staff was very high (mean satisfaction ≥9 in a score ranging from 0 to 10) both in the usual-care and Urban Training groups (online supplementary table S7). Satisfaction with the study components in the Urban Training group was high or very high: 9.1±1.6 for trail maps, 9.1±1.7 for calendars, 9.0±1.8 for pedometers, 7.5±2.8 for walking groups, 9.4±1.0 for phone text messages, 9.5±1.4 for study phoneline and 8.7±2.3 for study website (online supplementary table S7).

Discussion

This randomised controlled trial showed that the Urban Training intervention is more efficacious than usual care in increasing physical activity after 12 months in patients with COPD, with few safety concerns. However, the intervention was not effective according to results with the ITT analysis set, suggesting that it improves physical activity only in willing, adherent patients. No effect of the intervention was found on severe COPD exacerbations, functional exercise capacity, body composition, health-related quality of life, anxiety or depression, in either analysis approach.

The main finding of this study is that the Urban Training intervention increased physical activity in COPD patients 1) at long-term (after 12 months) and 2) in a large scale of magnitude. Most studies testing the effects of behavioural physical activity interventions in COPD patients have successfully resulted in positive effects only at short-term (≈3 months) [6, 7], and only one reported a long-term increase, which was restricted to a post hoc subgroup analysis [9]. Examination of the content of previous and current successful physical activity interventions allows us to hypothesise that the combination of motivational interviews, pedometers and diaries/calendars may be key for the long-term effect. The ≈900 steps·day−1 increase observed in the Urban Training group lies within the defined limits of the minimal important difference in COPD patients (between 600 and 1100 steps·day−1) [32] and is greater than the 255 steps·day−1 change observed in the long-term physical activity COPD trial referred to above and the mean 808 steps·day−1 change identified in a review of pedometer-based physical activity interventions in older adults (including follow-ups between 2 weeks and 23 months) [30]. Our contention is that customising walking trails to patients’ individual (e.g. exercise capacity and motivation), interpersonal (e.g. social support and cultural habit of walking) and environmental factors (e.g. lack of steep stairs in walking trails and home proximity or bus access to them) may have contributed to the long-term duration and large magnitude of the intervention effect. Therefore, Urban Training appears to be an attractive intervention potentially feasible due to its simplicity and reduced burden.

Potential harms of the Urban Training intervention need to be discussed. First, patients in the Urban Training group reported lower-extremity muscle pain in a higher proportion than patients in the usual-care group, without differences in lower-extremity joint pain or other adverse events. This could be attributed to the fact that the Urban Training walking trails included ramps and stairs that may promote eccentric work of the leg muscles, which may result in muscle but not joint pain [33]. Second, although a recent trial has reported an acute increase in respiratory symptoms after walking in urban polluted areas [34], we did not collect information on these potential adverse events because 1) most of the trails were located in green or blue areas and 2) residential air pollution exposure was comparable between groups by design. Finally, the fact that patients included in the ITT but not in the per-protocol analysis set experienced greater decline in physical activity than those in the per-protocol analysis set could suggest that the intervention was harmful for them (which could have made them non-adherent). However, this is not supported by the fact that they experienced the same frequency of adverse events during or after walks as the rest of the Urban Training group and that a natural decline of physical activity levels has been observed previously in the absence of interventions [35, 36].

The Urban Training intervention did not improve most of the secondary and exploratory outcomes. The lack of effect on functional exercise capacity was unexpected, since, based on the physiological response generated when walking the trails during the validation study [17], we hypothesised that the intervention could produce effects similar to those of typical exercise training interventions. However, the lack of daily supervision when walking the trails may have hindered patients from regularly achieve a minimum training intensity (e.g. walking at a pace that generates dyspnoea or fatigue scores between 4 and 6 in the Borg scale). Indeed, a previous intervention that increased both physical activity and functional exercise capacity after 3 months had included close patient supervision via telecoaching [8]. The remaining secondary outcomes (severe COPD exacerbations, body composition, quality of life, anxiety or depression) were not primarily targeted by any of the Urban Training components and their improvement was expected only as a result of the expected increase in physical activity. Based on our results, it is tempting to speculate that the improvement in physical activity levels would need to be sustained for a period >12 months in order to result in measurable changes in the other health outcomes. Another explanation is that our patients already had a relatively good health status as per their values in COPD admissions, quality of life, anxiety or depression; therefore, they had little room for improvement. Finally, the Urban Training intervention improved patients’ experience of their physical activity (exploratory outcome), in both the amount and difficulty dimensions, which supports that this concept provides complementary information to other related constructs such as health-related quality of life or exercise-induced symptoms [37].

The findings of this study are encouraging for COPD research and its management as well as for physical activity promotion in other populations. First, our findings highlight the consideration of patients’ interpersonal (social and cultural) factors and environment when designing further interventions. From the clinical viewpoint, this approach may appear more feasible than others based strongly on technology solutions, particularly in countries with limited healthcare budgets. Second, our study supports the involvement of behaviour specialists in the design and administration of physical activity interventions or an equivalent acquisition of knowledge on behavioural techniques by health professionals who generally exhibit a lack of training in behavioural change techniques [38, 39]. Finally, at the city level, interventions such as the Urban Training may contribute towards amortising the investment in public space (otherwise underused during certain times of the day) thus improving its sustainability. In fact, a close collaboration between health professionals and local governments has been promoted for example in the World Health Organization Healthy Cities project and is likely to result in social, economic and health benefits for all [40].

A limitation of the current study is that we defined adherence, and consequently the per-protocol analysis set, according to patient report. It is of note that we defined “non-adherence” from patient report and “adherence” otherwise. Thus, the ITT analysis set included, in the first place, patients who at baseline spontaneously reported unwillingness to undergo the intervention they had been assigned to. These patients are most often excluded from clinical trials, but we decided to keep them (and analyse their data) in order to provide effectiveness estimates. Second, the ITT analysis set included in addition patients who reported at the 12-month visit that they had not been adherent to the intervention to which they had been assigned, which in most cases, was due to a family situation (e.g. partner undergoing surgery). Again, some of these patients would be excluded in traditional clinical trials. Finally, the per-protocol analysis set included patients who did not make any spontaneous report in relation to their willingness or adherence, and probably comprised both adherent and non-adherent patients, thus underestimating the efficacy of Urban Training.

A second limitation is the apparent discrepancy between efficacy and effectiveness results. Of note, both approaches were prespecified in our analysis plan given previous reports in the literature about poor adherence to behavioural interventions [9, 41] and the well-known argument against ITT analysis (that it underestimates intervention effects in situations of non-adherence) [42]. The absence of effectiveness of Urban Training suggests the need for research to understand and eventually to identify ways to act upon the determinants of willingness and adherence to behavioural interventions in COPD. In our study, airflow limitation, smoking habits, diabetes and depression symptoms, but not physical activity levels were related to unwillingness or non-adherence, although collected information was not complete and there are no previous data on these issues to compare with. In addition, it has been disputed that the adherence to a given intervention may change dramatically after patients learn of trial findings, making the ITT effect estimation different from the effectiveness of the intervention in the community [43]. From a clinical viewpoint, patients who are willing to take an intervention such as Urban Training may be more interested in the per-protocol than the ITT effect.

Other shortcomings include the lack of intermediate assessments during the follow-up period, which could have given feedback to patients and would have allowed researchers to distinguish between short- and long-term effects. In addition, the fact that ≈30% of patients were lost to follow-up, a comparable figure to previous studies [6, 9, 10], could have biased our results. Finally, our patients exhibited higher physical activity levels than those observed in previous studies [44–47], which could be considered a limitation of our research. However, a comparison of the clinical characteristics and physical activity levels of the patients included in the present and previous studies shows differences in physical activity both between countries (for the same severity of COPD) and within countries (for different severity stages and/or recruitment settings). We consider that, given that the Urban Training intervention was designed in a region characterised by relatively high social support, the cultural habit of walking, pedestrian accessibility to most outdoor public spaces, and a mild climate, it would be feasible in most Euro-Mediterranean cities. However, other geographic areas would need to conduct a proper adaptation to their social, cultural and environmental characteristics.

Strengths of the study are the novelty of customising the behavioural intervention to patients’ interpersonal characteristics and environment, the large sample size and the measure of physical activity using an accelerometer. In addition, patients were recruited from primary care and hospitals of several municipalities, with barely any exclusion criteria, and diversity in relevant sociodemographic, lifestyle and clinical parameters, which make our results generalisable to a wide COPD population. The lack of differences in efficacy when patients were stratified according to their baseline features further supports the generalisability of our findings. With regard to the intervention, its simplicity and reduced burden make it possible to adapt it to other populations, including those with other chronic diseases and/or settings.

In conclusion, the Urban Training intervention, combining behavioural strategies with unsupervised outdoor walking, was efficacious in increasing physical activity after 12 months in COPD patients. However, it was ineffective in the full population including unwilling and self-reported non-adherent patients. The Urban Training intervention had no effect on severe COPD exacerbations, functional exercise capacity, body composition, health-related quality of life, anxiety or depression.

Supplementary material

Supplementary Material

Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.

Supplementary material ERJ-00063-2018_Supplement

Acknowledgements

The authors thank all the technical staff of the Respiratory Diagnostic Centre from Hospital Clínic de Barcelona (Barcelona, Spain); Laura Gutierrez, Concepción Ballano, Anna Rodó-Pin, Bea Valeiro, Mireia Admetlló and Sergi Pascual from the Pneumology Department of Hospital del Mar (Barcelona); Alicia Francoso Vicente and Júlia Moraleda Hidalgo from the Pneumology Department of Hospital Germans Trias i Pujol (Badalona, Spain); and Marta Delicado and the Administration Department from the Viladecans 2 Primary care centre (Viladecans, Spain) for their contribution to the study.

Footnotes

  • This article has supplementary material available from erj.ersjournals.com

  • Urban Training is trademark registered in Spain (ref. 3502702/9).

  • This study is registered at ClinicalTrials.gov with identifier number NCT01897298. The corresponding author can provide, upon request, individual participant data that underlie the results reported in this article (except variables, if any, that may allow identification of patients), after applying necessary measures to guarantee that no individual is identified or identifiable.

  • Author contributions: A. Arbillaga-Etxarri and J. Garcia-Aymerich prepared the first draft of the paper; A. Arbillaga-Etxarri, M. Benet and J. Garcia-Aymerich had full access to the data and carried out statistical analysis. A. Arbillaga-Etxarri, E. Gimeno-Santos, A. Barberan-Garcia, E. Balcells, E. Borrell, N. Celorrio, A. Delgado, C. Jané, A. Marin, C. Martín-Cantera, M. Monteagudo, N. Montellà, P. Ortega, D.A. Rodríguez, P. Simonet, P. Torán-Monserrat, J. Torrent-Pallicer and J. Garcia-Aymerich contributed to data collection and coordination. All authors 1) provided substantial contributions to the conception or design of the work, or the acquisition, analysis or interpretation of data for the work; 2) revised the manuscript for important intellectual content; 3) approved the final version; and 4) agreed to be accountable for all aspects of the work. J. Garcia-Aymerich had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  • Conflict of interest: A. Arbillaga-Etxarri has nothing to disclose.

  • Conflict of interest: E. Gimeno-Santos has nothing to disclose.

  • Conflict of interest: A. Barberan-Garcia has nothing to disclose.

  • Conflict of interest: E. Balcells has nothing to disclose.

  • Conflict of interest: M. Benet has nothing to disclose.

  • Conflict of interest: E. Borrell has nothing to disclose.

  • Conflict of interest: N. Celorrio has nothing to disclose.

  • Conflict of interest: A. Delgado has nothing to disclose.

  • Conflict of interest: C. Jané has nothing to disclose.

  • Conflict of interest: A. Marin has nothing to disclose.

  • Conflict of interest: C. Martín-Cantera has nothing to disclose.

  • Conflict of interest: M. Monteagudo has nothing to disclose.

  • Conflict of interest: N. Montellà has nothing to disclose.

  • Conflict of interest: L. Muñoz has nothing to disclose.

  • Conflict of interest: P. Ortega has nothing to disclose.

  • Conflict of interest: D.A. Rodríguez has nothing to disclose.

  • Conflict of interest: R. Rodríguez-Roisin reports grants from Almirall and Menarini, personal fees for advisory board work from Boehringer Ingelheim, Pearl Therapeutics and TEVA, personal fees for lecturinf from Novartis and Takeda, during the conduct of the study, all related to COPD.

  • Conflict of interest: P. Simonet reports personal fees for speaking from Menarini, Gebro, Teva, Boehringer, Rovi, AstraZeneca and GSK, outside the submitted work.

  • Conflict of interest: P. Torán-Monserrat has nothing to disclose.

  • Conflict of interest: J. Torrent-Pallicer has nothing to disclose.

  • Conflict of interest: P. Vall-Casas has nothing to disclose.

  • Conflict of interest: J. Vilaró has nothing to disclose.

  • Conflict of interest: J. Garcia-Aymerich reports personal fees for consulting and lecture fees paid to institution from AstraZeneca, personal fees for lecturing from Esteve and Chiesi, outside the submitted work.

  • Support statement: The study was funded by grants from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (ISCIII, PI11/01283 and PI14/0419), integrated into Plan Estatal I+D+I 2013–2016 and co-funded by ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and Fondo Europeo de Desarrollo Regional (FEDER); Sociedad Española de Neumología y Cirugía Torácica (SEPAR, 147/2011 and 201/2011), Societat Catalana de Pneumologia (Ajuts al millor projecte en fisioteràpia respiratòria 2013). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Anael Barberan-Garcia had personal funding from AGAUR 2014-SGR-661, Catalan Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received January 11, 2018.
  • Accepted August 6, 2018.
  • Copyright ©ERS 2018.

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

References

  1. ↵
    1. Vorrink SN,
    2. Kort HS,
    3. Troosters T, et al.
    Level of daily physical activity in individuals with COPD compared with healthy controls. Respir Res 2011; 12: 33.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Gimeno-Santos E,
    2. Frei A,
    3. Steurer-Stey C, et al.
    Determinants and outcomes of physical activity in patients with COPD: a systematic review. Thorax 2014; 69: 731–739.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Leidy NK,
    2. Kimel M,
    3. Ajagbe L, et al.
    Designing trials of behavioral interventions to increase physical activity in patients with COPD: insights from the chronic disease literature. Respir Med 2014; 108: 472–481.
    OpenUrl
  4. ↵
    1. Singh S
    . One step at a time. Lifestyle physical activity interventions. Ann Am Thorac Soc 2016; 13: 586–587.
    OpenUrl
  5. ↵
    1. Conn VS,
    2. Hafdahl AR,
    3. Brown SA, et al.
    Meta-analysis of patient education interventions to increase physical activity among chronically ill adults. Patient Educ Couns 2008; 70: 157–172.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    1. Lahham A,
    2. McDonald CF,
    3. Holland AE
    . Exercise training alone or with the addition of activity counseling improves physical activity levels in COPD: a systematic review and meta-analysis of randomized controlled trials. Int J Chron Obstruct Pulmon Dis 2016; 11: 3121–3136.
    OpenUrl
  7. ↵
    1. Mantoani LC,
    2. Rubio N,
    3. McKinstry B, et al.
    Interventions to modify physical activity in patients with COPD: a systematic review. Eur Respir J 2016; 48: 69–81.
    OpenUrlAbstract/FREE Full Text
  8. ↵
    1. Demeyer H,
    2. Louvaris Z,
    3. Frei A, et al.
    Physical activity is increased by a 12-week semiautomated telecoaching programme in patients with COPD: a multicentre randomised controlled trial. Thorax 2017; 72: 415–423.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Altenburg WA,
    2. ten Hacken NHT,
    3. Bossenbroek L, et al.
    Short- and long-term effects of a physical activity counselling programme in COPD: a randomized controlled trial. Respir Med 2015; 109: 112–121.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Coultas DB,
    2. Jackson BE,
    3. Russo R, et al.
    A lifestyle physical activity intervention for patients with chronic obstructive pulmonary disease. A randomized controlled trial. Ann Am Thorac Soc 2016; 13: 617–626.
    OpenUrl
  11. ↵
    1. Moy ML,
    2. Martinez CH,
    3. Kadri R, et al.
    Long-term effects of an internet-mediated pedometer-based walking program for chronic obstructive pulmonary disease: randomized controlled trial. J Med Internet Res 2016; 18: e215.
    OpenUrl
  12. ↵
    1. Bauman AE,
    2. Reis RS,
    3. Sallis JF, et al.
    Correlates of physical activity: why are some people physically active and others not? Lancet 2012; 380: 258–271.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    World Health Organization (WHO). Interventions on Diet and Physical Activity: What Works. Geneva, WHO, 2015.
  14. ↵
    1. Arbillaga-Etxarri A,
    2. Gimeno-Santos E,
    3. Barberan-Garcia A, et al.
    Socio-environmental correlates of physical activity in patients with chronic obstructive pulmonary disease (COPD). Thorax 2017; 72: 796–802.
    OpenUrlAbstract/FREE Full Text
    1. Mesquita R,
    2. Nakken N,
    3. Janssen DJA, et al.
    Activity levels and exercise motivation in patients with COPD and their resident loved ones. Chest 2017; 151: 1028–1038.
    OpenUrl
  15. ↵
    1. Chen Z,
    2. Fan VS,
    3. Belza B, et al.
    Association between social support and self-care behaviors in adults with chronic obstructive pulmonary disease. Ann Am Thorac Soc 2017; 14: 1419–1427.
    OpenUrl
  16. ↵
    1. Arbillaga-Etxarri A,
    2. Torrent-Pallicer J,
    3. Gimeno-Santos E, et al.
    Validation of walking trails for the Urban Training of chronic obstructive pulmonary disease patients. PLoS One 2016; 11: e0146705.
    OpenUrl
  17. ↵
    1. Palacios-Ceña D,
    2. Alonso-Blanco C,
    3. Jiménez-Garcia R, et al.
    Time trends in leisure time physical activity and physical fitness in elderly people: 20 year follow-up of the Spanish population national health survey (1987–2006). BMC Public Health 2011; 11: 799.
    OpenUrlCrossRefPubMed
  18. ↵
    1. Celli BR,
    2. MacNee W,
    3. Agusti A, et al.
    Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932–946.
    OpenUrlFREE Full Text
  19. ↵
    1. Hopewell S,
    2. Clarke M,
    3. Moher D, et al.
    CONSORT for reporting randomised trials in journal and conference abstracts. Lancet 2008; 371: 281–283.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    1. Boutron I,
    2. Moher D,
    3. Altman DG, et al.
    Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments. Ann Intern Med 2008; 148: W60–W66.
    OpenUrlPubMedWeb of Science
  21. ↵
    European Lung Foundation (ELF) 2013 Living an Active Life with COPD. Date last accessed: May 4 2016. Date last updated: February 2018. www.europeanlung.org/assets/files/en/publications/living-an-active-life-with-copd-en.pdf
  22. ↵
    1. William MR,
    2. Rollnick S
    . Motivational Interviewing: Preparing People for Change. New York, Guilford Press, 2002.
  23. ↵
    1. Prochaska JO,
    2. Velicer WF
    . The transtheoretical model of health behavior change. Am J Health Promot 1997; 12: 38–48.
    OpenUrlCrossRefPubMedWeb of Science
  24. ↵
    1. Pescatello L,
    2. Arena R,
    3. Riebe DTP
    . General principles of exercise prescription. In: ACSM's Guidelines for Exercise Testing and Prescription. 9th edn Philadelphia, Wolters Kluwer Health/Lippincott Williams & Wilkins, 2013; pp. 166–177.
  25. ↵
    1. Spruit MA,
    2. Singh SJ,
    3. Garvey C, et al.
    An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med 2013; 188: e13–e64.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Rabinovich RA,
    2. Louvaris Z,
    3. Raste Y, et al.
    Validity of physical activity monitors during daily life in patients with COPD. Eur Respir J 2013; 42: 1205–1215.
    OpenUrlAbstract/FREE Full Text
  27. ↵
    1. Van Remoortel H,
    2. Raste Y,
    3. Louvaris Z, et al.
    Validity of six activity monitors in chronic obstructive pulmonary disease: a comparison with indirect calorimetry. PLoS One 2012; 7: e39198.
    OpenUrlCrossRefPubMed
  28. ↵
    1. Demeyer H,
    2. Burtin C,
    3. Van Remoortel H, et al.
    Standardizing the analysis of physical activity in patients with COPD following a pulmonary rehabilitation program. Chest 2014; 146: 318–327.
    OpenUrlCrossRefPubMedWeb of Science
  29. ↵
    1. Tudor-Locke C,
    2. Craig CL,
    3. Aoyagi Y, et al.
    How many steps/day are enough? For older adults and special populations. Int J Behav Nutr Phys Act 2011; 8: 80.
    OpenUrlCrossRefPubMed
  30. ↵
    1. Murray EJ,
    2. Hernán MA
    . Adherence adjustment in the Coronary Drug Project: a call for better per-protocol effect estimates in randomized trials. Clin Trials 2016; 13: 372–378.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Demeyer H,
    2. Burtin C,
    3. Hornikx M, et al.
    The minimal important difference in physical activity in patients with COPD. PLoS One 2016; 11: e0154587.
    OpenUrl
  32. ↵
    1. MacMillan NJ,
    2. Kapchinsky S,
    3. Konokhova Y, et al.
    Eccentric ergometer training promotes locomotor muscle strength but not mitochondrial adaptation in patients with severe chronic obstructive pulmonary disease. Front Physiol 2017; 8: 114.
    OpenUrl
  33. ↵
    1. Sinharay R,
    2. Gong J,
    3. Barratt B, et al.
    Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. Lancet 2018; 391: 339–349.
    OpenUrl
  34. ↵
    1. Waschki B,
    2. Kirsten AM,
    3. Holz O, et al.
    Disease progression and changes in physical activity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med.2015; 192: 295–306.
    OpenUrlCrossRefPubMed
  35. ↵
    1. Clarenbach CF,
    2. Sievi NA,
    3. Haile SR, et al.
    Determinants of annual change in physical activity in COPD. Respirology 2017; 22: 1133–1139.
    OpenUrl
  36. ↵
    1. Gimeno-Santos E,
    2. Raste Y,
    3. Demeyer H, et al.
    The PROactive instruments to measure physical activity in patients with chronic obstructive pulmonary disease. Eur Respir J 2015; 46: 988–1000.
    OpenUrlAbstract/FREE Full Text
  37. ↵
    1. Blackmore C,
    2. Johnson-Warrington VL,
    3. Williams JE, et al.
    Development of a training program to support health care professionals to deliver the SPACE for COPD self-management program. Int J Chron Obstruct Pulmon Dis 2017; 12: 1669–1681.
    OpenUrl
  38. ↵
    1. Khan A,
    2. Dickens AP,
    3. Adab P, et al.
    Self-management behaviour and support among primary care COPD patients: cross-sectional analysis of data from the Birmingham Chronic Obstructive Pulmonary Disease Cohort. NPJ Prim Care Respir Med 2017; 27: 46.
    OpenUrlCrossRefPubMed
  39. ↵
    1. Rydin Y,
    2. Bleahu A,
    3. Davies M, et al.
    Shaping cities for health: complexity and the planning of urban environments in the 21st century. Lancet 2012; 379: 2079–2108.
    OpenUrlCrossRefPubMedWeb of Science
  40. ↵
    1. Bourbeau J,
    2. Bartlett SJ
    . Patient adherence in COPD. Thorax 2008; 63: 831–838.
    OpenUrlAbstract/FREE Full Text
  41. ↵
    1. Hernán MA,
    2. Hernández-Díaz S
    . Beyond the intention-to-treat in comparative effectiveness research. Clin Trials 2012; 9: 48–55.
    OpenUrlCrossRefPubMedWeb of Science
  42. ↵
    1. Hernán MA,
    2. Robins JM
    . Per-protocol analyses of pragmatic trials. N Engl J Med 2017; 377: 1391–1398.
    OpenUrlCrossRefPubMed
  43. ↵
    1. Vorrink SNW,
    2. Kort HSM,
    3. Troosters T, et al.
    Efficacy of an mHealth intervention to stimulate physical activity in COPD patients after pulmonary rehabilitation. Eur Respir J 2016; 48: 1019–1029.
    OpenUrlAbstract/FREE Full Text
    1. Burtin C,
    2. Langer D,
    3. van Remoortel H, et al.
    Physical activity counselling during pulmonary rehabilitation in patients with COPD: a randomised controlled trial. PLoS One 2015; 10: e0144989.
    OpenUrlCrossRefPubMed
    1. Watz H,
    2. Waschki B,
    3. Boehme C, et al.
    Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study. Am J Respir Crit Care Med 2008; 177: 743–751.
    OpenUrlCrossRefPubMedWeb of Science
  44. ↵
    1. Egan C,
    2. Deering BM,
    3. Blake C, et al.
    Short term and long term effects of pulmonary rehabilitation on physical activity in COPD. Respir Med 2012; 106: 1671–1679.
    OpenUrlCrossRefPubMed
View Abstract
PreviousNext
Back to top
View this article with LENS
Vol 52 Issue 4 Table of Contents
European Respiratory Journal: 52 (4)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial
Ane Arbillaga-Etxarri, Elena Gimeno-Santos, Anael Barberan-Garcia, Eva Balcells, Marta Benet, Eulàlia Borrell, Nuria Celorrio, Anna Delgado, Carme Jané, Alicia Marin, Carlos Martín-Cantera, Mónica Monteagudo, Nuria Montellà, Laura Muñoz, Pilar Ortega, Diego A. Rodríguez, Robert Rodríguez-Roisin, Pere Simonet, Pere Torán-Monserrat, Jaume Torrent-Pallicer, Pere Vall-Casas, Jordi Vilaró, Judith Garcia-Aymerich
European Respiratory Journal Oct 2018, 52 (4) 1800063; DOI: 10.1183/13993003.00063-2018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial
Ane Arbillaga-Etxarri, Elena Gimeno-Santos, Anael Barberan-Garcia, Eva Balcells, Marta Benet, Eulàlia Borrell, Nuria Celorrio, Anna Delgado, Carme Jané, Alicia Marin, Carlos Martín-Cantera, Mónica Monteagudo, Nuria Montellà, Laura Muñoz, Pilar Ortega, Diego A. Rodríguez, Robert Rodríguez-Roisin, Pere Simonet, Pere Torán-Monserrat, Jaume Torrent-Pallicer, Pere Vall-Casas, Jordi Vilaró, Judith Garcia-Aymerich
European Respiratory Journal Oct 2018, 52 (4) 1800063; DOI: 10.1183/13993003.00063-2018
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Abstract
    • Introduction
    • Methods
    • Results
    • Discussion
    • Supplementary material
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

Original Articles

  • Pharmacogenomics of ICS and lung function decline in COPD
  • Reference genes determination for real-time PCR using induced sputum samples
  • Detailed history and test results for diagnosis of asthma in children
Show more Original Articles

COPD

  • Pharmacogenomics of ICS and lung function decline in COPD
  • Inhaled AAT in patients with severe AATD and frequent exacerbations of COPD
  • Exacerbation action plans for patients with COPD and comorbidities
Show more COPD

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Collections
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2019 by the European Respiratory Society