European Respiratory Journal: 52 (4)

01 October 2018; volume 52, issue 4

Podcast

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ERJ Podcast October 2018: Causal inference studies
European Respiratory Journal 52 (4) 18E5204; DOI: 10.1183/13993003.E5204-2018 Published 29 October 2018

Editorials

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A new era for treatment of drug-resistant tuberculosis
Neel R. Gandhi, James C.M. Brust, N. Sarita Shah

European Respiratory Journal 52 (4) 1801350; DOI: 10.1183/13993003.01350-2018 Published 4 October 2018
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The Severe Paediatric Asthma Collaborative in Europe (SPACE) ERS Clinical Research Collaboration: enhancing participation of children with asthma in therapeutic trials of new biologics and receptor blockers
Franca Rusconi, Ricardo M. Fernandes, Mariëlle W.H. Pijnenburg, Jonathan Grigg on behalf of the SPACE Clinical Research Collaboration

European Respiratory Journal 52 (4) 1801665; DOI: 10.1183/13993003.01665-2018 Published 18 October 2018
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The European Sleep Apnoea Database (ESADA) ERS Clinical Research Collaboration: past, present and future
Maria R. Bonsignore, Jan Hedner on behalf of the ESADA study group

European Respiratory Journal 52 (4) 1801666; DOI: 10.1183/13993003.01666-2018 Published 10 October 2018
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Escaping the Plato's cave of latent tuberculosis testing: a path for developers of predictive tests for risk of tuberculosis
Morten Ruhwald, Roland Diel

European Respiratory Journal 52 (4) 1801616; DOI: 10.1183/13993003.01616-2018 Published 25 October 2018
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Kudzu and sleeper cells: the varied ecology of respiratory infections
Robert P. Dickson

European Respiratory Journal 52 (4) 1801607; DOI: 10.1183/13993003.01607-2018 Published 25 October 2018
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Physical activity: the key to cardiometabolic risk reduction in obstructive sleep apnoea
Monique Mendelson, Patrice Flore

European Respiratory Journal 52 (4) 1801775; DOI: 10.1183/13993003.01775-2018 Published 10 October 2018
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Risk assessment in patients with systemic sclerosis and pulmonary arterial hypertension
Karen M. Olsson, Marius M. Hoeper

European Respiratory Journal 52 (4) 1801745; DOI: 10.1183/13993003.01745-2018 Published 18 October 2018
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Whither pulmonary rehabilitation? Will alternative modes help or hurt?
Richard Casaburi

European Respiratory Journal 52 (4) 1801678; DOI: 10.1183/13993003.01678-2018 Published 18 October 2018
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Breaking news: DNA damage and repair pathways in COPD and implications for pathogenesis and treatment
Ian M. Adcock, Sharon Mumby, Gaetano Caramori

European Respiratory Journal 52 (4) 1801718; DOI: 10.1183/13993003.01718-2018 Published 4 October 2018
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Optimisation of chemotherapy in the era of immunotherapy
René Boosman, Jacobus (Sjaak) Adrianus Burgers

European Respiratory Journal 52 (4) 1801698; DOI: 10.1183/13993003.01698-2018 Published 25 October 2018

Perspective

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An evaluation framework for new tests that predict progression from tuberculosis infection to clinical disease
Sandra V. Kik, Samuel Schumacher, Daniela Maria Cirillo, Gavin Churchyard, Catharina Boehme, Delia Goletti, Molebogeng X. Rangaka, Claudia M. Denkinger, Christian Lienhardt, Christopher Gilpin, Alberto Matteelli, Frank Cobelens

European Respiratory Journal 52 (4) 1800946; DOI: 10.1183/13993003.00946-2018 Published 25 October 2018

Original Articles

Lung infection
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  Evaluation of the airway microbiome in nontuberculous mycobacteria disease
  Imran Sulaiman, Benjamin G. Wu, Yonghua Li, Adrienne S. Scott, Patrick Malecha, Benjamin Scaglione, Jing Wang, Ashwin Basavaraj, Samuel Chung, Katrina Bantis, Joseph Carpenito, Jose C. Clemente, Nan Shen, Jamie Bessich, Samaan Rafeq, Gaetene Michaud, Jessica Donington, Charissa Naidoo, Grant Theron, Gail Schattner, Suzette Garofano, Rany Condos, David Kamelhar, Doreen Addrizzo-Harris, Leopoldo N. Segal
  
  European Respiratory Journal 52 (4) 1800810; DOI: 10.1183/13993003.00810-2018 Published 25 October 2018
Asthma and basic science
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  The “one airway, one disease” concept in light of Th2 inflammation
  Lisa Giovannini-Chami, Agnès Paquet, Céline Sanfiorenzo, Nicolas Pons, Julie Cazareth, Virginie Magnone, Kévin Lebrigand, Benoit Chevalier, Ambre Vallauri, Valérie Julia, Charles-Hugo Marquette, Brice Marcet, Sylvie Leroy, Pascal Barbry
  
  European Respiratory Journal 52 (4) 1800437; DOI: 10.1183/13993003.00437-2018 Published 25 October 2018
Asthma
- Open Access
  Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma
  Eugene R. Bleecker, Michael E. Wechsler, J. Mark FitzGerald, Andrew Menzies-Gow, Yanping Wu, Ian Hirsch, Mitchell Goldman, Paul Newbold, James G. Zangrilli
  
  European Respiratory Journal 52 (4) 1800936; DOI: 10.1183/13993003.00936-2018 Published 18 October 2018
Tuberculosis
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  Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities
  Sara C. Auld, N. Sarita Shah, Barun Mathema, Tyler S. Brown, Nazir Ismail, Shaheed Vally Omar, James C.M. Brust, Kristin N. Nelson, Salim Allana, Angela Campbell, Koleka Mlisana, Pravi Moodley, Neel R. Gandhi
  
  European Respiratory Journal 52 (4) 1800246; DOI: 10.1183/13993003.00246-2018 Published 18 October 2018
Sleep apnoea
- Open Access
  Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial
  Sophie D. West, Benjamin Prudon, Joan Hughes, Rajen Gupta, Seid B. Mohammed, Stephen Gerry, John R. Stradling, for the ROSA trial investigators
  
  European Respiratory Journal 52 (4) 1801177; DOI: 10.1183/13993003.01177-2018 Published 25 October 2018
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  Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study
  Marcos Mônico-Neto, Hanna Karen Moreira Antunes, Ronaldo Vagner Thomatieli dos Santos, Vânia D'Almeida, Altay Alves Lino de Souza, Lia Rita Azeredo Bittencourt, Sergio Tufik
  
  European Respiratory Journal 52 (4) 1701972; DOI: 10.1183/13993003.01972-2017 Published 10 October 2018
Pulmonary hypertension
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  Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension
  Jason Weatherald, Athénaïs Boucly, David Launay, Vincent Cottin, Grégoire Prévot, Delphine Bourlier, Claire Dauphin, Ari Chaouat, Laurent Savale, Xavier Jaïs, Mitja Jevnikar, Julie Traclet, Pascal De Groote, Gérald Simonneau, Eric Hachulla, Luc Mouthon, David Montani, Marc Humbert, Olivier Sitbon
  
  European Respiratory Journal 52 (4) 1800678; DOI: 10.1183/13993003.00678-2018 Published 18 October 2018
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  Chronic blood exchange transfusions in the management of pre-capillary pulmonary hypertension complicating sickle cell disease
  Matthieu Turpin, Christelle Chantalat-Auger, Florence Parent, Françoise Driss, François Lionnet, Anoosha Habibi, Bernard Maître, Alice Huertas, Xavier Jaïs, Jason Weatherald, David Montani, Olivier Sitbon, Gérald Simonneau, Fréderic Galactéros, Marc Humbert, Pablo Bartolucci, Laurent Savale
  
  European Respiratory Journal 52 (4) 1800272; DOI: 10.1183/13993003.00272-2018 Published 10 October 2018
COPD
- Open Access
  Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial
  Ane Arbillaga-Etxarri, Elena Gimeno-Santos, Anael Barberan-Garcia, Eva Balcells, Marta Benet, Eulàlia Borrell, Nuria Celorrio, Anna Delgado, Carme Jané, Alicia Marin, Carlos Martín-Cantera, Mónica Monteagudo, Nuria Montellà, Laura Muñoz, Pilar Ortega, Diego A. Rodríguez, Robert Rodríguez-Roisin, Pere Simonet, Pere Torán-Monserrat, Jaume Torrent-Pallicer, Pere Vall-Casas, Jordi Vilaró, Judith Garcia-Aymerich
  
  European Respiratory Journal 52 (4) 1800063; DOI: 10.1183/13993003.00063-2018 Published 18 October 2018
Basic science and COPD
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  The DNA repair transcriptome in severe COPD
  Maor Sauler, Maxime Lamontagne, Eric Finnemore, Jose D. Herazo-Maya, John Tedrow, Xuchen Zhang, Julia E. Morneau, Frank Sciurba, Wim Timens, Peter D. Paré, Patty J. Lee, Naftali Kaminski, Yohan Bossé, Jose L. Gomez
  
  European Respiratory Journal 52 (4) 1701994; DOI: 10.1183/13993003.01994-2017 Published 4 October 2018
Lung cancer
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  Renal impairment during pemetrexed maintenance in patients with advanced nonsmall cell lung cancer: a cohort study
  Sabine Visser, Jeannine Huisbrink, Nils E. van ‘t Veer, Jermo J. van Toor, Anton J.M. van Boxem, Nico C. van Walree, Bruno H. Stricker, Joachim G.J.V. Aerts
  
  European Respiratory Journal 52 (4) 1800884; DOI: 10.1183/13993003.00884-2018 Published 25 October 2018
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  Anti-tumour effect of low molecular weight heparin in localised lung cancer: a phase III clinical trial
  Guy Meyer, Benjamin Besse, Hélène Doubre, Anaïs Charles-Nelson, Sandro Aquilanti, Armine Izadifar, Reza Azarian, Isabelle Monnet, Corinne Lamour, Renaud Descourt, Gérard Oliviero, Laurent Taillade, Christos Chouaid, Frederique Giraud, Pierre-Emmanuel Falcoz, Marie-Pierre Revel, Virginie Westeel, Adrien Dixmier, Jean Tredaniel, Stéphanie Dehette, Chantal Decroisette, Alain Prevost, Eric Pichon, Elizabeth Fabre, Jean-Charles Soria, Sylvie Friard, Jean-Baptiste Stern, Laurence Jabot, Georges Dennewald, Gérard Pavy, Patrick Petitpretz, Jean-Marc Tourani, Marco Alifano, Gilles Chatellier, Philippe Girard
  
  European Respiratory Journal 52 (4) 1801220; DOI: 10.1183/13993003.01220-2018 Published 4 October 2018
Cystic fibrosis
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  Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease
  Joshua D. Chandler, Camilla Margaroli, Hamed Horati, Matthew B. Kilgore, Mieke Veltman, H. Ken Liu, Alexander J. Taurone, Limin Peng, Lokesh Guglani, Karan Uppal, Young-Mi Go, Harm A.W.M. Tiddens, Bob J. Scholte, Rabindra Tirouvanziam, Dean P. Jones, Hettie M. Janssens
  
  European Respiratory Journal 52 (4) 1801118; DOI: 10.1183/13993003.01118-2018 Published 10 October 2018
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  SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration
  Megan J. Webster, Boris Reidel, Chong D. Tan, Arunava Ghosh, Neil E. Alexis, Scott H. Donaldson, Mehmet Kesimer, Carla M.P. Ribeiro, Robert Tarran
  
  European Respiratory Journal 52 (4) 1800668; DOI: 10.1183/13993003.00668-2018 Published 4 October 2018

Review

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Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature
Timm Volmer, Timo Effenberger, Christoph Trautner, Roland Buhl

European Respiratory Journal 52 (4) 1800703; DOI: 10.1183/13993003.00703-2018 Published 25 October 2018

Back to Basics

Open Access
The mode of action of anticholinergics in asthma
Reinoud Gosens, Nicholas Gross

European Respiratory Journal 52 (4) 1701247; DOI: 10.1183/13993003.01247-2017 Published 4 October 2018

ERJ Methods

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Nuclear magnetic resonance-based metabolomics in respiratory medicine
Debora Paris, Mauro Maniscalco, Andrea Motta

European Respiratory Journal 52 (4) 1801107; DOI: 10.1183/13993003.01107-2018 Published 4 October 2018

Agora

Research letters
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  Risk assessment in scleroderma patients with newly diagnosed pulmonary arterial hypertension: application of the ESC/ERS risk prediction model
  Valentina Mercurio, Nermin Diab, Grace Peloquin, Traci Housten-Harris, Rachel Damico, Todd M. Kolb, Stephen C. Mathai, Paul M. Hassoun
  
  European Respiratory Journal 52 (4) 1800497; DOI: 10.1183/13993003.00497-2018 Published 18 October 2018
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  Hands are vehicles for transmission of Streptococcus pneumoniae in novel controlled human infection study
  Victoria Connor, Esther German, Sherin Pojar, Elena Mitsi, Caroline Hales, Elissavet Nikolaou, Angela Hyder-Wright, Hugh Adler, Seher Zaidi, Helen Hill, Simon P. Jochems, Hassan Burhan, Neil French, Timothy Tobery, Jamie Rylance, Daniela M. Ferreira
  
  European Respiratory Journal 52 (4) 1800599; DOI: 10.1183/13993003.00599-2018 Published 10 October 2018
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  The Mechanical Ventilation–Respiratory Distress Observation Scale as a surrogate of self-reported dyspnoea in intubated patients
  Maxens Decavèle, Frédérick Gay, Romain Persichini, Julien Mayaux, Capucine Morélot-Panzini, Thomas Similowski, Alexandre Demoule
  
  European Respiratory Journal 52 (4) 1800598; DOI: 10.1183/13993003.00598-2018 Published 10 October 2018
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  Effect of the CXCR2 antagonist danirixin on symptoms and health status in COPD
  Aili L. Lazaar, Bruce E. Miller, Maggie Tabberer, John Yonchuk, Nancy Leidy, Claire Ambery, Jackie Bloomer, Henrik Watz, Ruth Tal-Singer
  
  European Respiratory Journal 52 (4) 1801020; DOI: 10.1183/13993003.01020-2018 Published 4 October 2018
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  Reducing the need for carbon dioxide monitoring in the investigation of paediatric sleep disordered breathing
  Federica Trucco, Andrew Bush, Hui-Leng Tan
  
  European Respiratory Journal 52 (4) 1801290; DOI: 10.1183/13993003.01290-2018 Published 4 October 2018
Correspondence
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  Risk factors for lung disease progression in children with cystic fibrosis
  Hafez Al Momani, Audrey Perry, Rhys Jones, Melissa McDonnell, Amaran Krishnan, Andrew Robertson, Mike Griffin, Robert Rutherford, Malcolm Brodlie, Jeff Pearson, Steve Bourke, Chris Ward
  
  European Respiratory Journal 52 (4) 1801492; DOI: 10.1183/13993003.01492-2018 Published 4 October 2018

Author Correction

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“Safety of nintedanib added to pirfenidone treatment for idiopathic pulmonary fibrosis.” Kevin R. Flaherty, Charlene D. Fell, J. Terrill Huggins, Hilario Nunes, Robert Sussman, Claudia Valenzuela, Ute Petzinger, John L. Stauffer, Frank Gilberg, Monica Bengus and Marlies Wijsenbeek. Eur Respir J 2018; 52: 1800230.
European Respiratory Journal 52 (4) 1850230; DOI: 10.1183/13993003.50230-2018 Published 4 October 2018

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Table of Contents

Podcast

Editorials

Perspective

Original Articles

Lung infection

Asthma and basic science

Asthma

Tuberculosis

Sleep apnoea

Pulmonary hypertension

COPD

Basic science and COPD

Lung cancer

Cystic fibrosis

Review

Back to Basics

ERJ Methods

Agora

Research letters

Correspondence

Author Correction

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