Extract
New spirometry reference values from the Global Lung Function Initiative (GLI) and the LUNOKID (Lungenfunktions-Normalwerte bei Kindern in Deutschland [Lung function Normal Values of Children in Germany]) study were published in 2012 and 2013, respectively, using a nonlinear model for lung function trajectories [1–3]. There is a lack of empirical testing of these new equations and reference values in longitudinal cohort studies.
Abstract
Lung function trajectories using different reference equations in a birth cohort up to the age of 20 years show a drop in FEV1 and FVC of both asthmatic and nonasthmatic subjects at the age of 13 years regardless of which reference equations were used http://ow.ly/hxGJ30ktUYE
Acknowledgements
Among all the collaborators over >20 years of MAS, the authors would especially like to thank Renate L. Bergmann and Christian E. Bergmann (Dept of Obstetrics, Charité – Universitätsmedizin Berlin, Berlin, Germany). The authors are also grateful to Ursula Krämer and Anke Hüls (Environmental Health Research Institute, Heinrich Heine University, Dusseldorf, Germany) for providing LUNOKID reference data.
Footnotes
Conflict of interest: S. Lau has served on advisory boards for DBV, ALK and Boehringer, outside the submitted work.
Conflict of interest: J. Forster reports receiving grants from Federal Ministry of Health during the conduct of the study.
Support statement: MAS was funded by grants from the German Federal Ministry of Education and Research (07015633, 07 ALE 27, 01EE9405/5 and 01EE9406) and the German Research Foundation (KE 1462/2-1). The funders had no role in the design, management, data collection, analysis or interpretation of the data or in the writing of the manuscript or the decision to submit for publication. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received February 21, 2018.
- Accepted June 11, 2018.
- Copyright ©ERS 2018