Figures
- FIGURE 1
Significant atrophy in the left temporal pole (LTP) and right fusiform gyrus (RFG) related to “oxygen desaturation” in older “at-risk” patients; displayed on Qdec's (query, design, estimate, contrast) semi-inflated cortical surfaces. a) Left lateral and left medial; b) right lateral and right medial; c) anterior and posterior; d) inferior and superior views. Results were obtained using Monte Carlo simulation, with a threshold of p<0.05, to provide cluster-wise correction for multiple comparisons. Clusters are labelled based on the location of the vertex with the greatest association as defined by Qdec.
- FIGURE 2
Significant hypertrophy in the postcentral gyrus (PCG), pars opercularis (PO) and pericalcarine (PA) related to “sleep disturbance” in older “at-risk” patients; displayed on Qdec's (query, design, estimate, contrast) semi-inflated cortical surfaces. a) Left lateral and left medial; b) right lateral and right medial; c) anterior and posterior; d) inferior and superior views. Results were obtained using Monte Carlo simulation, with a threshold of p<0.05, to provide cluster-wise correction for multiple comparisons. Clusters are labelled based on the location of the vertex with the greatest association as defined by Qdec.
- FIGURE 3
Significant linear regressions between “sleep disturbance” in older “at-risk” patients and grey matter volume of a) hippocampal and b) amygdala subcortical regions. Volume was calculated using FreeSurfer automated segmentation. Analysis was conducted accounting for age and intracranial volume.
Tables
- TABLE 1
Demographic and clinical statistics of the sample
Age years 51.1–88.5 67.4±7.5 Education years 4.0–23.0 13.3±3.2 Body mass index kg·m−2 15.7–64.4 27.8±6.8 Mini-Mental State Examination total score 24.0–30.0 28.6±1.6 Geriatric Depression Scale total score 0.0–15.0 4.1±3.6 Cumulative Illness Rating Scale total score 0.0–17.0 4.8±3.8 Alcohol consumption drinks per week 0.0–35.0 4.7±6.8 Epworth Sleepiness Scale total score 0.0–19.0 7.6±4.4 Apnoea–hypopnoea index events·h−1 0.0–111.0 18.7±20.2 Oxygen desaturation index events·h−1 0.0–109.7 15.1±19.1 Lowest oxygen saturation % 71.0–97.0 85.6±6.1 Oxygen saturation <90% %TST 0.0–46.1 4.4±8.2 Sleep efficiency % 37.4–96.0 75.7±12.1 Awakening index events·h−1 1.8–49.4 6.6±6.8 Arousal index events·h−1 5.4–78.9 19.8±14.7 Data are presented as range or mean±sd. n=83. %TST: percentage of total sleep time.
- TABLE 2
Rotated component matrix of the principal components analysis of obstructive sleep apnoea severity metrics
Component “Oxygen desaturation” “Sleep disturbance” Apnoea–hypopnoea index 0.774 0.489 Oxygen desaturation index 0.856 0.311 %TST saturation oxygen <90% 0.842 0.154 Lowest oxygen saturation (inverted) 0.855 −0.115 Sleep efficiency (inverted) 0.001 0.768 Awakening index events·h−1 0.115 0.780 Arousal index events·h−1 0.454 0.734 Variance explained % 42.8 30.1 Extraction method: principal component analysis; rotation method: varimax with Kaiser normalisation. Variables with a loading >0.5 on each component are presented in bold. %TST: percentage of total sleep time.
Supplementary Material
Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.
Supplementary tables ERJ-00740-2018_Supplement
