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In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss

Igor L. Chernyavsky, Richard J. Russell, Ruth M. Saunders, Gavin E. Morris, Rachid Berair, Amisha Singapuri, Latifa Chachi, Adel H. Mansur, Peter H. Howarth, Patrick Dennison, Rekha Chaudhuri, Stephen Bicknell, Felicity R.A.J. Rose, Salman Siddiqui, Bindi S. Brook, Christopher E. Brightling
European Respiratory Journal 2018 51: 1701680; DOI: 10.1183/13993003.01680-2017
Igor L. Chernyavsky
1School of Mathematics, University of Manchester, Manchester, UK
10These authors contributed equally to the study
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  • ORCID record for Igor L. Chernyavsky
Richard J. Russell
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
10These authors contributed equally to the study
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Ruth M. Saunders
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
10These authors contributed equally to the study
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Gavin E. Morris
3Dept of Cardiovascular Sciences, University of Leicester, Leicester, UK
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Rachid Berair
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
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Amisha Singapuri
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
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Latifa Chachi
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
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Adel H. Mansur
4Heart of England NHS Trust, Birmingham, UK
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Peter H. Howarth
5Clinical and Experimental Sciences, University of Southampton, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Trust, Southampton, UK
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Patrick Dennison
5Clinical and Experimental Sciences, University of Southampton, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Trust, Southampton, UK
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Rekha Chaudhuri
6Gartnavel General Hospital, Glasgow, UK
7Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
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Stephen Bicknell
6Gartnavel General Hospital, Glasgow, UK
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Felicity R.A.J. Rose
8Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
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Salman Siddiqui
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
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Bindi S. Brook
9School of Mathematical Sciences, University of Nottingham, Nottingham, UK
11Co-senior authors
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Christopher E. Brightling
2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
11Co-senior authors
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Article Information

vol. 51 no. 5
DOI 
https://doi.org/10.1183/13993003.01680-2017
PubMed 
29700102

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received August 17, 2017
  • Accepted March 29, 2018
  • Published online May 24, 2018.

Article Versions

  • previous version (April 26, 2018 - 04:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2018 This ERJ Open article is open access and distributed under the terms of the Creative Commons Attribution Licence 4.0.

Author Information

  1. Igor L. Chernyavsky1,10,
  2. Richard J. Russell2,10,
  3. Ruth M. Saunders2,10,
  4. Gavin E. Morris3,
  5. Rachid Berair2,
  6. Amisha Singapuri2,
  7. Latifa Chachi2,
  8. Adel H. Mansur4,
  9. Peter H. Howarth5,
  10. Patrick Dennison5,
  11. Rekha Chaudhuri6,7,
  12. Stephen Bicknell6,
  13. Felicity R.A.J. Rose8,
  14. Salman Siddiqui2,
  15. Bindi S. Brook9,11 and
  16. Christopher E. Brightling2,11
  1. 1School of Mathematics, University of Manchester, Manchester, UK
  2. 2Dept of Infection, Immunity and Inflammation, Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
  3. 3Dept of Cardiovascular Sciences, University of Leicester, Leicester, UK
  4. 4Heart of England NHS Trust, Birmingham, UK
  5. 5Clinical and Experimental Sciences, University of Southampton, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Trust, Southampton, UK
  6. 6Gartnavel General Hospital, Glasgow, UK
  7. 7Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
  8. 8Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
  9. 9School of Mathematical Sciences, University of Nottingham, Nottingham, UK
  10. 10These authors contributed equally to the study
  11. 11Co-senior authors
  1. Igor L. Chernyavsky, School of Mathematics, University of Manchester, Oxford Road, Manchester M13 9PL, UK. E-mail: Igor.Chernyavsky{at}manchester.ac.uk
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Funding

  • Medical Research Council

    MR/M004643/1; MR/N011538/1
  • National Institute for Health Research

    Leicester Biomedical Research Centre
  • Wellcome Trust

    WT082265
  • FP7 Information and Communication Technologies

    270194

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In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
Igor L. Chernyavsky, Richard J. Russell, Ruth M. Saunders, Gavin E. Morris, Rachid Berair, Amisha Singapuri, Latifa Chachi, Adel H. Mansur, Peter H. Howarth, Patrick Dennison, Rekha Chaudhuri, Stephen Bicknell, Felicity R.A.J. Rose, Salman Siddiqui, Bindi S. Brook, Christopher E. Brightling
European Respiratory Journal May 2018, 51 (5) 1701680; DOI: 10.1183/13993003.01680-2017

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In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
Igor L. Chernyavsky, Richard J. Russell, Ruth M. Saunders, Gavin E. Morris, Rachid Berair, Amisha Singapuri, Latifa Chachi, Adel H. Mansur, Peter H. Howarth, Patrick Dennison, Rekha Chaudhuri, Stephen Bicknell, Felicity R.A.J. Rose, Salman Siddiqui, Bindi S. Brook, Christopher E. Brightling
European Respiratory Journal May 2018, 51 (5) 1701680; DOI: 10.1183/13993003.01680-2017
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