Extract
Pulmonary hypertension (PH) is a common complication of left heart disease (LHD), as the result of a “passive” increase of left atrial pressure (LAP), leading to isolated post-capillary PH [1–3]. Several haemodynamic parameters have been proposed to identify a more severe phenotype of PH-LHD, for which the increase in pulmonary artery pressure cannot be accounted for by the increase in LAP, and described as combined post-capillary PH with a pre-capillary component, or CpcPH [1–3]. The latter haemodynamic phenotype may potentially expose patients to a higher risk of right ventricular failure and a poorer outcome [4, 5]. However, since the last World Symposium in 2013, how to define the pre-capillary component in PH-LHD has been a matter of debate, as pathophysiological arguments have been suggested to potentially contrast with clinical and prognostic evidences [1].
Abstract
PVR, DPG, PAC are all associated with survival in pulmonary hypertension due to left heart disease http://ow.ly/R8sF30ieHSQ
Acknowledgements
The authors would like to thank Irene Lang, Christian Gerges and Mario Gerges (Division of Cardiology, Department of Internal Medicine II, General Hospital Vienna (AKH-Wien), Medical University of Vienna, Vienna, Austria) for having provided their own data, otherwise not available for this meta-analysis.
Footnotes
Support statement: S. Caravita is the recipient of a ERS PAH Short-Term Research Training Fellowship (STRTF 2014-5264) supported by an unrestricted grant by GSK, and of the international grant “Cesare Bartorelli” for the year 2014 funded by the Italian Society of Hypertension. J-L. Vachiery is the holder of the Actelion Research Chair on Pulmonary Hypertension in his department.
Conflict of interest: J-L. Vachiéry has received grants from Actelion, outside the submitted work.
Conflict of interest: S. Caravita has received a travel grant from Actelion, outside the submitted work.
- Received November 23, 2017.
- Accepted January 23, 2018.
- Copyright ©ERS 2018