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Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement

Jakko van Ingen, Timothy Aksamit, Claire Andrejak, Erik C. Böttger, Emmanuelle Cambau, Charles L. Daley, David E. Griffith, Lorenzo Guglielmetti, Steven M. Holland, Gwen A. Huitt, Won-Jung Koh, Christoph Lange, Philip Leitman, Theodore K. Marras, Kozo Morimoto, Kenneth N. Olivier, Miguel Santin, Jason E. Stout, Rachel Thomson, Enrico Tortoli, Richard J. Wallace Jr, Kevin L. Winthrop, Dirk Wagner for NTM-NET
European Respiratory Journal 2018 51: 1800170; DOI: 10.1183/13993003.00170-2018
Jakko van Ingen
1Dept of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands
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  • For correspondence: Jakko.vaningen@radboudumc.nl
Timothy Aksamit
2Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Mayo Clinic, Rochester, MN, USA
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Claire Andrejak
3Respiratory and Intensive Care Unit, University Hospital Amiens, Amiens, France
4EA 4294, AGIR, Jules Verne Picardy University, Amiens, France
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Erik C. Böttger
5Institute of Medical Microbiology, National Reference Center for Mycobacteria, University of Zurich, Zurich, Switzerland
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Emmanuelle Cambau
6National Reference Center for Mycobacteria and Antimycobacterial Resistance, APHP, Hôpitaux universitaires Saint Louis-Lariboisière-Fernand Widal, Bacteriology, Paris, France
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Charles L. Daley
7Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO, USA
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David E. Griffith
8Pulmonary Infectious Disease Section, University of Texas Health Science Center, Tyler, TX, USA
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Lorenzo Guglielmetti
9APHP − Hôpital Lariboisière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la résistance des Mycobactéries aux Antituberculeux, Paris, France
10Université Paris Diderot, Sorbonne Paris Cité, INSERM, IAME UMR1137, Paris, France
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Steven M. Holland
11Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
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Gwen A. Huitt
7Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO, USA
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Won-Jung Koh
12Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
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Christoph Lange
13Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
14German Center for Infection Research (DZIF), Germany
15International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
16Dept of Medicine, Karolinska Institute, Stockholm, Sweden
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Philip Leitman
17NTM Info & Research, Miami, FL, USA
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Theodore K. Marras
18Dept of Medicine, University of Toronto and University Health Network, Toronto, ON, Canada
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Kozo Morimoto
19Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan
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Kenneth N. Olivier
20Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA
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Miguel Santin
21Service of Infectious Diseases, Bellvitge University Hospital-IDIBELL, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain
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Jason E. Stout
22Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA
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Rachel Thomson
23Gallipoli Medical Research Centre, University of Queensland, Brisbane, Australia
24The Prince Charles and Princess Alexandra Hospitals, Brisbane, Australia
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Enrico Tortoli
25Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
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Richard J. Wallace Jr
26Mycobacteria/Nocardia Laboratory, Dept of Microbiology, The University of Texas Health Science Center, Tyler, TX, USA
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Kevin L. Winthrop
27Divisions of Infectious Diseases, Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, USA
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Dirk Wagner
28Division of Infectious Diseases, Dept of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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Abstract

Improving treatment outcome reporting in NTM disease: NTM-NET (@ntmnet) consensus statement on treatment outcome definitions http://ow.ly/c6IC30iwLM4

Introduction

Nontuberculous mycobacterial pulmonary diseases (NTM-PD) are increasingly recognised as opportunistic infections of humans. These chronic pulmonary infections have two main presentations. The first is a fibro-cavitary disease, that occurs in patients with pre-existing pulmonary diseases, such as chronic obstructive pulmonary disease, bronchiectasis, previous tuberculosis or other structural lung disease. The second presentation is a nodular-bronchiectatic disease of primarily the lingula and middle lobe that tends to affect a middle-aged and elderly female population [1].

Treatment of NTM-PD requires long-term administration of complex multidrug therapies that are species-specific. Currently recommended regimens are supported by a very limited evidence base [2, 3]. The increasing incidence of NTM-PD has sparked increased interest in performing prospective randomised clinical trials [4]. One of the drawbacks of the existing case series and clinical trials is that they have applied different outcome measures [5]. This hampers meta-analyses, which are important in these still understudied infectious diseases.

To enhance the quality and interpretability of the results of future trials and retrospective cohort studies, we aimed to formulate clear and broadly acceptable outcome definitions for NTM-PD treatment.

Methods

Critical outcome parameters were selected and their draft definitions were produced during two meetings (Copenhagen, April 2015; San Diego, October 2015) of the American Thoracic Society/European Respiratory Society/Infectious Diseases Society of America/European Society of Clinical Microbiology and Infectious Diseases committee writing the upcoming guidelines on diagnosis and treatment of NTM-PD, and during the 4th biannual NTM-NET meeting (Amsterdam, September 2015). During these meetings, present panel members were asked to formulate what they considered key outcome parameters that required definitions. Then, panel members were asked to come up with possible definitions and their potential limitations. The lead author (J. van Ingen) took notes during these meetings and selected the outcome parameters and prepared the first draft definitions from these notes. Four additional experts within NTM-NET (T. Aksamit, W-J. Koh, K. Morimoto, R. Thomson) were then counselled to ensure a broader and geographically more diverse group.

A five-round revision and voting process was initiated, following previously used methodology [6]. The outcome definitions were developed in this stepwise mechanism:

Step 1: Preliminary definitions, drafted by the lead author during the meetings, were shared with panel members, with an invitation to send in alternatives.

Step 2: Alternative definitions were collected by the coordinating author.

Step 3: All panel members and the additional NTM-NET experts were asked to select one preferred definition from those drafted in steps 1 and 2. The vote was blinded to all other participants.

Step 4: For each definition, the one that received most votes was selected for inclusion in this statement.

Step 5: All participants were asked to indicate their agreement or disagreement with the selected definition. Results of the decisions are indicated at the end of each definition.

All voting procedures were managed by the lead author (J. van Ingen) and performed by e-mail, with ballots prepared using Microsoft Excel software. All votes were counted independently by lead and senior authors (J. van Ingen, D. Wagner). Definitions were accepted if agreement of >80% of the participants was reached.

Results

23 NTM-NET members participated in writing this statement. For each parameter, the complete list of possible definitions sent out for voting in Step 3 is presented in table 1. The final definitions are presented in bold face in table 1, with the results of voting in step 4 and the extent of consensus achieved in step 5.

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TABLE 1

List of definitions

Discussion

To improve the quality in reporting and enable meta-analyses of clinical studies, we are now proposing consensus definitions for key outcome parameters to be used in the treatment of NTM-PD. These definitions can also aid in the design of future clinical trials for new treatment regimens.

Consensus on the definition for cure proved hardest to obtain due to the risk of reinfection in patients with NTM-PD. For other diseases, including tuberculosis (TB), the term “cure” is reserved for patients remaining disease-free for a specified period after the end of treatment [6, 7]. For NTM this is more complicated; (clinical) cure is based on a decrease in, rather than full resolution of, symptoms, because of underlying lung diseases and exposure to the causative agents is likely commonplace owing to their ubiquity in the environment [1, 2]. Typing tools to distinguish relapses from reinfections and thus to offer feedback on treatment effect are not widely available yet and have not been standardised and validated [8]. Hence, for now, adding a disease-free period after treatment cessation to define cure did not obtain a majority of expert votes. Aware of this limitation, we propose to use the end of treatment as the moment to define cure. In the future, with validated biomarkers of disease and tools for strain typing, the definition of cure may include a period of disease-free survival with negative cultures.

There was very high agreement for definitions other than for cure, although the vote in step 3 did not always yield a clear favourite. Some draft definitions varied only in details (e.g. one or two positive cultures; table 1); in absence of any evidence in favour of either option, having agreed-upon definitions was perhaps considered as important as their exact details.

Applying these definitions, a single positive culture after culture conversion does not yet mean treatment failure. This stresses the importance of requesting repeated follow-up cultures after culture conversion and end of treatment. Sputum induction or bronchoscopy, perhaps with computed tomography imaging for guidance, may be required to obtain good quality respiratory specimens to determine treatment outcome. Essentially, a single positive culture after culture conversion equals that of a single positive culture at the time of first diagnosis [2].

The next challenge is how to convert these definitions into uniform clinical practice. A pressing issue is what to do when patients meet the definition for failure. Is that the point when a switch to a second-line regimen is warranted? The timing set out in the current definition, after 12 months of treatment, may be regarded by some to be too conservative. One may question whether it is ethical to wait that long in patients still culture positive after 6 months of guideline-compliant NTM-PD treatment. In addition, this timing aspect may be different for disease caused by different NTM species or for different disease manifestations, i.e. fibro-cavitary disease versus nodular-bronchiectatic disease. In multidrug-resistant TB, a manifestation of TB that shares similar features to NTM-PD in respect to management, adverse events of therapy, prognosis and costs, a positive culture status at 6 months of therapy has recently been suggested to define failure [9]. The recent study on semi-quantitative cultures to monitor treatment effect suggests that a lack of microbiological response after 6 months of treatment is a very accurate predictor of treatment failure (non-response) at 12 months and beyond [10], and this time point has thus been chosen in ongoing clinical trials in failing patients [4]; on the other hand, culture conversion after month 6 certainly does occur [11, 12].

Proper use of these outcome definitions does set requirements for standards of care for NTM-PD patients. For example, to effectively monitor culture conversion and (microbiological) cure requires submission of multiple good-quality sputum samples, but may also require computed tomography (CT) imaging and guided bronchoscopy for bronchoalveolar lavage (BAL) specimens, at set times during and after the entire course of treatment. Also, monitoring improvement in symptoms and signs to establish clinical cure requires the use of validated instruments to measure these. The recent recommendations on diagnosis and treatment of NTM-PD in cystic fibrosis patients provide pragmatic schemes to set these standards [3]. Nonetheless, standards of care specific to NTM-PD and relevant to all patients would still be helpful.

These definitions and the process by which they were set have some important limitations. First, these definitions result from a debate that included expert pulmonologists, infectious disease physicians, microbiologists and a patient representative. Thus, the process and its outcomes are based on expert opinion rather than a systematic review of the literature, a shortcoming also noted for the TB-NET document [4] from which the methodology was derived [13]. This methodology was chosen for its pragmatism, in a field devoid of data to support weighing of relevance of outcomes based on systematic review. This method also introduces selection bias as most members of this NTM-NET committee are in frequent contact and this may have already introduced uniformity in the definition and use of outcome parameters; also, four panel members joined after the initial drafting, hence could only vote, not draft. Second, these outcome definitions reflect the outcomes of current treatment regimens. With the advent of new treatment modalities for NTM-PD, including new antibiotics, time to sputum culture conversion may be shortened and this could affect the definition of treatment failure. Third, in the absence of other validated biomarkers for treatment response, these definitions rely heavily on culture of respiratory specimens. This is problematic in patients who do not produce sputum and may require CT imaging, guided bronchoscopy and the acquisition of BAL fluid specimens to determine culture conversion and cure, as stated in the recent British Thoracic Society guidelines on NTM-PD management [14]. Non-culture-based biomarkers for diagnosis and treatment response remain urgently needed. Radiological improvement as a marker is helpful but does not, by definition, follow the clinical and microbiological response to treatment [15, 16]. Fourth, molecular detection of NTM directly in clinical specimens is still not commonplace, but is likely to become routine in the upcoming years [17]. The interpretation of its results and how these affect current outcome definitions should be subject of future studies. Last, for many (especially retrospective) studies, the data gathered will not allow use of all outcomes defined here. For example, the distinction of recurrences into relapses and reinfections requires molecular typing data.

In summary, we have achieved international expert consensus on treatment outcome definitions for NTM-PD, using a five-round drafting and voting process. There was very high agreement among experts for all outcome definitions with the exception of the definition for cure. Definitions will need to be re-evaluated when more longitudinal clinical data on NTM-PD become available. We encourage the application of these definitions in both clinical management and in future studies and their design. Uniform outcome measures and reports will facilitate meta-analyses of trials and case series, which in turn will increase the quality of evidence available to support treatment regimens for these difficult-to-treat infections.

Acknowledgements

The authors wish to thank the American Thoracic Society, European Respiratory Society, Infectious Diseases Society of America and European Society of Clinical Microbiology and Infectious Diseases for organising the two meetings during which the process leading to this statement was initiated. These organisations do not officially endorse this NTM-NET consensus statement.

Footnotes

  • Conflict of interest: E. Cambau has received non-financial support for travel from ESCMID, during the conduct of the study.

  • Conflict of interest: C.L. Daley has received grants and personal fees from Insmed, outside the submitted work.

  • Conflict of interest: C. Lange has received personal fees for independent lectures at sponsored symposia from Chiesi, Gilead, Abbvie, MSD, Becton Dickinson, Janssen, Lucane, Novartis and Thermofisher, outside the submitted work.

  • Conflict of interest: T.K.. Marras has received grants from Insmed (site investigator for clinical trial, funds paid to institution), personal fees for consultancy (for designing clinical trials in NTM lung disease, with all funds paid to institution) from Insmed and RedHill, and personal fees from AstraZeneca (honoraria for CME on mycobacterial disease, funds paid to institution), outside the submitted work.

  • Conflict of interest: K. Morimoto has received personal fees for consultancy from INSMED, outside the submitted work.

  • Conflict of interest: K.N. Olivier received grants from Insmed Inc. and Matinas Biopharma, during the conduct of the study.

  • Conflict of interest: R. Thomson received consultancy fees for work unrelated to this manuscript from Insmed and Savara.

  • Support statement: Funded in part by the Division of Intramural Research, National Heart, Lung and Blood Institute, NIH. J. van Ingen is supported by a personal grant from the Netherlands Organization for Scientific Research NWO/ ZonMW (Veni 016.176.024).

  • Received October 8, 2017.
  • Accepted January 26, 2018.
  • The content of this work is not subject to copyright. Design and branding are copyright ©ERS 2018.

References

  1. ↵
    1. Stout JE,
    2. Koh WJ,
    3. Yew WW
    . Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis 2016; 45: 123–134.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Griffith DE,
    2. Aksamit T,
    3. Brown-Elliot BA, et al.
    An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007; 175: 367–416.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Floto RA,
    2. Olivier KN,
    3. Saiman L, et al.
    US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. Thorax 2016; 71: Suppl. 1, 1–22.
    OpenUrlFREE Full Text
  4. ↵
    1. Olivier KN,
    2. Griffith DE,
    3. Eagle G, et al.
    Randomized trial of liposomal amikacin for inhalation in nontuberculous mycobacterial lung disease. Am J Respir Crit Care Med 2017; 195: 814–823.
    OpenUrlCrossRef
  5. ↵
    1. van Ingen J,
    2. Ferro BE,
    3. Hoefsloot W, et al.
    Drug treatment of pulmonary nontuberculous mycobacterial disease in HIV-negative patients: the evidence. Expert Rev Anti Infect Ther 2013; 11: 1065–1077.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Lange C,
    2. Abubakar I,
    3. Alffenaar JW, et al.
    Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement. Eur Respir J 2014; 44: 23–63.
    OpenUrlAbstract/FREE Full Text
  7. ↵
    World Health Organization. Definitions and reporting framework for tuberculosis – 2013 revision. Geneva, World Health Organization, 2013.
  8. ↵
    1. Jagielski T,
    2. Minias A,
    3. van Ingen J, et al.
    Molecular epidemiology of Mycobacterium tuberculosis and other mycobacteria: methodological and clinical aspects. Clin Microbiol Rev 2016; 29: 239–290.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Günther G,
    2. Lange C,
    3. Alexandru S, et al.
    Treatment outcomes in multidrug-resistant tuberculosis. N Engl J Med 2016; 375: 1103–1105.
    OpenUrl
  10. ↵
    1. Griffith DE,
    2. Adjemian J,
    3. Brown-Elliott BA, et al.
    Semiquantitative culture analysis during therapy for Mycobacterium avium complex lung disease. Am J Respir Crit Care Med 2015; 192: 754–760.
    OpenUrlCrossRef
  11. ↵
    1. Zweijpfenning S,
    2. Kops S,
    3. Magis-Escurra C, et al.
    Treatment and outcome of non-tuberculous mycobacterial pulmonary disease in a predominantly fibro-cavitary disease cohort. Respir Med 2017; 131: 220–224.
    OpenUrl
  12. ↵
    1. Wallace RJ Jr.,
    2. Brown-Elliott BA,
    3. McNulty S, et al.
    Macrolide/azalide therapy for nodular/bronchiectatic Mycobacterium avium complex lung disease. Chest 2014; 146: 276–282.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Sotgiu G,
    2. Woodhead M
    . Good news about a bad subject: scientific evidence to help defeat multidrug/extensively drug-resistant tuberculosis. Eur Respir J 2014; 44: 5–7.
    OpenUrlFREE Full Text
  14. ↵
    1. Haworth CS,
    2. Banks J,
    3. Capstick T, et al.
    British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD). Thorax 2017; 72: Suppl. 2, ii1–ii64.
    OpenUrlFREE Full Text
  15. ↵
    1. Lee G,
    2. Kim HS,
    3. Lee KS, et al.
    Serial CT findings of nodular bronchiectatic Mycobacterium avium complex pulmonary disease with antibiotic treatment. AJR Am J Roentgenol 2013; 201: 764–772.
    OpenUrlCrossRefPubMed
  16. ↵
    1. Czaja CA,
    2. Levin AR,
    3. Cox CW, et al.
    Improvement in quality of life after therapy for Mycobacterium abscessus group lung infection. A prospective cohort study. Ann Am Thorac Soc 2016; 13: 40–48.
    OpenUrlCrossRef
  17. ↵
    1. Deggim-Messmer V,
    2. Bloemberg GV,
    3. Ritter C, et al.
    Diagnostic molecular mycobacteriology in regions with low tuberculosis endemicity: combining real-time PCR assays for detection of multiple Mycobacterial pathogens with line probe assays for identification of resistance mutations. EBioMedicine 2016; 9: 228–237.
    OpenUrl
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Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement
Jakko van Ingen, Timothy Aksamit, Claire Andrejak, Erik C. Böttger, Emmanuelle Cambau, Charles L. Daley, David E. Griffith, Lorenzo Guglielmetti, Steven M. Holland, Gwen A. Huitt, Won-Jung Koh, Christoph Lange, Philip Leitman, Theodore K. Marras, Kozo Morimoto, Kenneth N. Olivier, Miguel Santin, Jason E. Stout, Rachel Thomson, Enrico Tortoli, Richard J. Wallace, Kevin L. Winthrop, Dirk Wagner
European Respiratory Journal Mar 2018, 51 (3) 1800170; DOI: 10.1183/13993003.00170-2018

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Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement
Jakko van Ingen, Timothy Aksamit, Claire Andrejak, Erik C. Böttger, Emmanuelle Cambau, Charles L. Daley, David E. Griffith, Lorenzo Guglielmetti, Steven M. Holland, Gwen A. Huitt, Won-Jung Koh, Christoph Lange, Philip Leitman, Theodore K. Marras, Kozo Morimoto, Kenneth N. Olivier, Miguel Santin, Jason E. Stout, Rachel Thomson, Enrico Tortoli, Richard J. Wallace, Kevin L. Winthrop, Dirk Wagner
European Respiratory Journal Mar 2018, 51 (3) 1800170; DOI: 10.1183/13993003.00170-2018
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