Tables
- TABLE 1
Baseline characteristics, conditions and clinical outcomes, and their associated cytomegalovirus (CMV) PCR results in bronchoalveolar lavage
Variable Negative CMV (n=98) Positive CMV (n=35) p-value Demographic Age years (median (IQR)) 62.0 (23.0) 61.0 (24.0) 0.37 Men 63 (64) 23 (66) 0.88 Current smoker 31 (36) 7 (25) 0.28 Current alcohol consumer 8 (10) 2 (7) >0.99 Immunocompromised# 47 (48) 25 (71) 0.017 HIV 8 (8) 3 (9) >0.99 Transplant 19 (19) 9 (26) 0.43 Cancer 16 (16) 7 (20) 0.62 Systemic corticosteroids¶ 21 (21) 17 (49) 0.002 Diagnosis at ICU admission 0.73 Respiratory failure 59 (60) 24 (69) Septic shock 18 (18) 5 (14) Cardiac failure 9 (9) 2 (6) Sepsis 5 (5) 1 (3) Other 7 (7) 3 (9) Previous antibiotic 7 (7) 3 (9) 0.72 Comorbidities+ 76 (78) 26 (74) 0.70 Chronic respiratory disease 27 (28) 8 (23) 0.55 Chronic cardiovascular disease 23 (24) 6 (17) 0.44 Diabetes mellitus 12 (12) 6 (17) 0.57 Neurological disease 11 (11) 7 (20) 0.25 Chronic renal disease 12 (12) 7 (20) 0.27 Chronic liver disease 4 (4) 2 (6) 0.65 Arterial hypertension 38 (39) 18 (51) 0.19 Laboratory tests (median (IQR)) Creatinine mg·mL−1 1.0 (1.0) 1.2 (1.1) 0.98 C-reactive protein mg·dL−1 12.5 (15.9) 11.9 (20.0) 0.87 White blood-cell count 109·L−1 10.0 (9.0) 9.0 (12.0) 0.41 SOFA score at ICU admission (median (IQR)) 5 (6) 5 (5) 0.91 Outcomes Pulmonary complications 16 (39) 5 (33) 0.70 NIMV 59 (94) 17 (94) >0.99 IMV 72 (92) 26 (93) >0.99 Hospital stay days (median (IQR)) 35.0 (33.0) 46.0 (62.0) 0.017 ICU stay days (median (IQR)) 19.5 (21.5) 31.5 (69.0) 0.070 30-day mortality 38 (41) 21 (64) 0.024 Data are presented as n (%) unless otherwise stated. Values in bold are for when p<0.05. IQR: interquartile range; ICU: intensive care unit; SOFA: sepsis-related organ failure assessment; NIMV: noninvasive mechanical ventilation; IMV: invasive mechanical ventilation. #: subjects may have more than one immunocompromising condition; ¶: daily doses >20 mg prednisolone-equivalent for more than 2 weeks in the month previous to admission; +: subjects may have more than one comorbid condition.