European Respiratory Journal: 51 (2)

01 February 2018; volume 51, issue 2

Electronic resources

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ERJ February Podcast: Effectiveness versus efficacy
European Respiratory Journal 51 (2) 18E5102; DOI: 10.1183/13993003.E5102-2018 Published 21 February 2018

Editorials

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Physical activity to improve health: do not forget that the lungs benefit too
Luis Puente-Maestu, William W. Stringer

European Respiratory Journal 51 (2) 1702468; DOI: 10.1183/13993003.02468-2017 Published 31 January 2018
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Treat the lungs, fool the brain and appease the mind: towards holistic care of patients who suffer from chronic respiratory diseases
Thomas Similowski

European Respiratory Journal 51 (2) 1800316; DOI: 10.1183/13993003.00316-2018 Published 1 March 2018
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The scale of the problem of obstructive lung disease in Africa becomes clearer, but where are the solutions?
Rupert Jones

European Respiratory Journal 51 (2) 1702562; DOI: 10.1183/13993003.02562-2017 Published 31 January 2018
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On Don Quixote and pink puffers: multi-organ loss of tissue COPD
Joan B. Soriano, Pierre-Régis Burgel

European Respiratory Journal 51 (2) 1702560; DOI: 10.1183/13993003.02560-2017 Published 7 February 2018
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Palliative care for people with COPD: effective but underused
David M.G. Halpin

European Respiratory Journal 51 (2) 1702645; DOI: 10.1183/13993003.02645-2017 Published 14 February 2018
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Revising our approach to conducting therapeutic clinical research in COPD
Gerard J. Criner

European Respiratory Journal 51 (2) 1702712; DOI: 10.1183/13993003.02712-2017 Published 21 February 2018
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Pseudomonas aeruginosa infection and exacerbations in bronchiectasis: more questions than answers
Miguel Angel Martinez-García

European Respiratory Journal 51 (2) 1702497; DOI: 10.1183/13993003.02497-2017 Published 31 January 2018
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Will we be singing a different tune on combined post- and pre-capillary pulmonary hypertension?
Steven Hsu, Ryan J. Tedford

European Respiratory Journal 51 (2) 1702589; DOI: 10.1183/13993003.02589-2017 Published 7 February 2018
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Heat shock protein-90 toward theranostics: a breath of fresh air in idiopathic pulmonary fibrosis
Philippe Bonniaud, Olivier Burgy, Carmen Garrido

European Respiratory Journal 51 (2) 1702612; DOI: 10.1183/13993003.02612-2017 Published 7 February 2018
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Putting the brake on accelerated lung function decline in asthma
Dominic Shaw

European Respiratory Journal 51 (2) 1702630; DOI: 10.1183/13993003.02630-2017 Published 14 February 2018
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Adolescents and young adults: a neglected population group for tuberculosis surveillance
Alberto L. García-Basteiro, H. Simon Schaaf, Roland Diel, Giovanni Battista Migliori

European Respiratory Journal 51 (2) 1800176; DOI: 10.1183/13993003.00176-2018 Published 21 February 2018
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The great breathlessness of cardiopulmonary diseases
Robert Naeije, Vitalie Faoro

European Respiratory Journal 51 (2) 1702517; DOI: 10.1183/13993003.02517-2017 Published 7 February 2018

Original Articles

Sleep
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  Effects of continuous positive airway pressure therapy on left ventricular diastolic function: a randomised, sham-controlled clinical trial
  Chi Young Shim, Darae Kim, Sungha Park, Chan Joo Lee, Hyung-Ju Cho, Jong-Won Ha, Yang-Je Cho, Geu-Ru Hong
  
  European Respiratory Journal 51 (2) 1701774; DOI: 10.1183/13993003.01774-2017 Published 31 January 2018
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  Palatal prolapse as a signature of expiratory flow limitation and inspiratory palatal collapse in patients with obstructive sleep apnoea
  Ali Azarbarzin, Scott A. Sands, Melania Marques, Pedro R. Genta, Luigi Taranto-Montemurro, Ludovico Messineo, David P. White, Andrew Wellman
  
  European Respiratory Journal 51 (2) 1701419; DOI: 10.1183/13993003.01419-2017 Published 14 February 2018
Physiology
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  Does physical fitness enhance lung function in children and young adults?
  Robert J. Hancox, Finn Rasmussen
  
  European Respiratory Journal 51 (2) 1701374; DOI: 10.1183/13993003.01374-2017 Published 31 January 2018
COPD
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  Mindfulness-based cognitive therapy in COPD: a cluster randomised controlled trial
  Ingeborg Farver-Vestergaard, Mia S. O'Toole, Maja O'Connor, Anders Løkke, Elisabeth Bendstrup, Sharee A. Basdeo, Donal J. Cox, Pádraic J. Dunne, Kai Ruggeri, Frances Early, Robert Zachariae
  
  European Respiratory Journal 51 (2) 1702082; DOI: 10.1183/13993003.02082-2017 Published 31 January 2018
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  Prevalence, risk factors and clinical correlates of COPD in a rural setting in Tanzania
  Ng'weina Francis Magitta, Richard William Walker, Komalkirti Keshavkiran Apte, Meshack Denson Shimwela, Julius David Mwaiselage, Anna Alphonce Sanga, Anil Kumar Namdeo, Sapna Jitendra Madas, Sundeep Santosh Salvi
  
  European Respiratory Journal 51 (2) 1700182; DOI: 10.1183/13993003.00182-2017 Published 31 January 2018
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  Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype
  Bartolome R. Celli, Nicholas Locantore, Ruth Tal-Singer, John Riley, Bruce Miller, Jørgen Vestbo, Julie C. Yates, Edwin K. Silverman, Caroline A. Owen, Miguel Divo, Victor Pinto-Plata, Emiel F.M. Wouters, Rosa Faner, Alvar Agusti on behalf of the ECLIPSE Study Investigators
  
  European Respiratory Journal 51 (2) 1702146; DOI: 10.1183/13993003.02146-2017 Published 7 February 2018
- Open Access
  Low uptake of palliative care for COPD patients within primary care in the UK
  Chloe I. Bloom, Bhavan Slaich, Daniel R. Morales, Liam Smeeth, Patrick Stone, Jennifer K. Quint
  
  European Respiratory Journal 51 (2) 1701879; DOI: 10.1183/13993003.01879-2017 Published 14 February 2018
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  Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology
  Naoya Tanabe, Dragoş M. Vasilescu, Miranda Kirby, Harvey O. Coxson, Stijn E. Verleden, Bart M. Vanaudenaerde, Daisuke Kinose, Yasutaka Nakano, Peter D. Paré, James C. Hogg
  
  European Respiratory Journal 51 (2) 1701245; DOI: 10.1183/13993003.01245-2017 Published 14 February 2018
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  Effectiveness versus efficacy trials in COPD: how study design influences outcomes and applicability
  Ashley Woodcock, Isabelle Boucot, David A. Leather, Jodie Crawford, Susan Collier, Nawar Diar Bakerly, Emma Hilton, Jørgen Vestbo
  
  European Respiratory Journal 51 (2) 1701531; DOI: 10.1183/13993003.01531-2017 Published 21 February 2018
Bronchiectasis
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  The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis
  David Araújo, Michal Shteinberg, Stefano Aliberti, Pieter C. Goeminne, Adam T. Hill, Thomas C. Fardon, Dusanka Obradovic, Glenda Stone, Marion Trautmann, Angela Davis, Katerina Dimakou, Eva Polverino, Anthony De Soyza, Melissa J. McDonnell, James D. Chalmers
  
  European Respiratory Journal 51 (2) 1701953; DOI: 10.1183/13993003.01953-2017 Published 31 January 2018
Pulmonary hypertension
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  Social deprivation and prognosis in Scottish patients with pulmonary arterial hypertension
  Katherine Pellino, Simon Kerridge, Colin Church, Andrew J. Peacock, Timothy Crowe, Geeshath Jayasekera, Martin K. Johnson, Alison M. MacKenzie
  
  European Respiratory Journal 51 (2) 1700444; DOI: 10.1183/13993003.00444-2017 Published 31 January 2018
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  Macitentan in pulmonary hypertension due to left ventricular dysfunction
  Jean-Luc Vachiéry, Marion Delcroix, Hikmet Al-Hiti, Michela Efficace, Martin Hutyra, Gabriela Lack, Kelly Papadakis, Lewis J. Rubin
  
  European Respiratory Journal 51 (2) 1701886; DOI: 10.1183/13993003.01886-2017 Published 7 February 2018
Basic science and interstitial lung disease
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  Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis
  Pierre-Simon Bellaye, Chiko Shimbori, Toyoshi Yanagihara, David A. Carlson, Philip Hughes, Chandak Upagupta, Seidai Sato, Nolan Wheildon, Timothy Haystead, Kjetil Ask, Martin Kolb
  
  European Respiratory Journal 51 (2) 1700386; DOI: 10.1183/13993003.00386-2017 Published 31 January 2018
Interstitial lung disease
- Open Access
  Sarcoidosis mortality in Sweden: a population-based cohort study
  Marios Rossides, Susanna Kullberg, Johan Askling, Anders Eklund, Johan Grunewald, Elizabeth V. Arkema
  
  European Respiratory Journal 51 (2) 1701815; DOI: 10.1183/13993003.01815-2017 Published 21 February 2018
Asthma
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  First trimester fetal size and prescribed asthma medication at 15 years of age
  Steve Turner, Shona Fielding, Graham Devereux
  
  European Respiratory Journal 51 (2) 1701509; DOI: 10.1183/13993003.01509-2017 Published 31 January 2018
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  Indoor bacteria and asthma in adults: a multicentre case–control study within ECRHS II
  Juha Pekkanen, Maria Valkonen, Martin Täubel, Christina Tischer, Hanna Leppänen, Päivi M. Kärkkäinen, Helena Rintala, Jan-Paul Zock, Lidia Casas, Nicole Probst-Hensch, Bertil Forsberg, Mathias Holm, Christer Janson, Isabelle Pin, Thorarinn Gislason, Debbie Jarvis, Joachim Heinrich, Anne Hyvärinen
  
  European Respiratory Journal 51 (2) 1701241; DOI: 10.1183/13993003.01241-2017 Published 7 February 2018
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  Predictors of accelerated decline in lung function in adult-onset asthma
  Hanneke Coumou, Guus A. Westerhof, Selma B. de Nijs, Aeilko H. Zwinderman, Elisabeth H. Bel
  
  European Respiratory Journal 51 (2) 1701785; DOI: 10.1183/13993003.01785-2017 Published 14 February 2018
Asthma and allergy
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  Small airways dysfunction: the link between allergic rhinitis and allergic asthma
  Amaryllis Haccuria, Alain Van Muylem, Andrei Malinovschi, Vi Doan, Alain Michils
  
  European Respiratory Journal 51 (2) 1701749; DOI: 10.1183/13993003.01749-2017 Published 21 February 2018
Asthma and paediatrics
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  Intravenous magnesium sulfate for acute wheezing in young children: a randomised double-blind trial
  Hannele Pruikkonen, Terhi Tapiainen, Merja Kallio, Teija Dunder, Tytti Pokka, Matti Uhari, Marjo Renko
  
  European Respiratory Journal 51 (2) 1701579; DOI: 10.1183/13993003.01579-2017 Published 7 February 2018
Paediatrics
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  Primary ciliary dyskinesia with normal ultrastructure: three-dimensional tomography detects absence of DNAH11
  Amelia Shoemark, Thomas Burgoyne, Robert Kwan, Mellisa Dixon, Mitali P. Patel, Andrew V. Rogers, Alexandros Onoufriadis, Juliet Scully, Farheen Daudvohra, Thomas Cullup, Michael R. Loebinger, Robert Wilson, Eddie M.K. Chung, Andrew Bush, Hannah M. Mitchison, Claire Hogg
  
  European Respiratory Journal 51 (2) 1701809; DOI: 10.1183/13993003.01809-2017 Published 21 February 2018
Tuberculosis
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  The effect of text messaging on latent tuberculosis treatment adherence: a randomised controlled trial
  James C. Johnston, Mia L. van der Kop, Kirsten Smillie, Gina Ogilvie, Fawziah Marra, Mohsen Sadatsafavi, Kamila Romanowski, Matthew A. Budd, Jan Hajek, Victoria Cook, Richard T. Lester
  
  European Respiratory Journal 51 (2) 1701488; DOI: 10.1183/13993003.01488-2017 Published 7 February 2018
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  The incidence of tuberculosis among adolescents and young adults: a global estimate
  Kathryn J. Snow, Charalambos Sismanidis, Justin Denholm, Susan M. Sawyer, Stephen M. Graham
  
  European Respiratory Journal 51 (2) 1702352; DOI: 10.1183/13993003.02352-2017 Published 21 February 2018
Infection
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  E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells
  Lisa Miyashita, Reetika Suri, Emma Dearing, Ian Mudway, Rosamund E Dove, Daniel R. Neill, Richard Van Zyl-Smit, Aras Kadioglu, Jonathan Grigg
  
  European Respiratory Journal 51 (2) 1701592; DOI: 10.1183/13993003.01592-2017 Published 7 February 2018
Lung function
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  Evolution of respiratory function in Duchenne muscular dystrophy from childhood to adulthood
  Antonella LoMauro, Marianna Romei, Sandra Gandossini, Riccardo Pascuzzo, Simone Vantini, Maria Grazia D'Angelo, Andrea Aliverti
  
  European Respiratory Journal 51 (2) 1701418; DOI: 10.1183/13993003.01418-2017 Published 7 February 2018
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  The role of air pollution and lung function in cognitive impairment
  Anke Hüls, Andrea Vierkötter, Dorothea Sugiri, Michael J. Abramson, Ulrich Ranft, Ursula Krämer, Tamara Schikowski
  
  European Respiratory Journal 51 (2) 1701963; DOI: 10.1183/13993003.01963-2017 Published 21 February 2018
Rare lung disease
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  Lung transplantation after allogeneic stem cell transplantation: a pan-European experience
  Mark Greer, Cristina Berastegui, Peter Jaksch, Christian Benden, John Aubert, Antoine Roux, Elodie Lhuillier, Sandrine Hirschi, Martine Reynaud-Gaubert, François Philit, Johanna Claustre, Pierre LePalud, Marc Stern, Christiane Knoop, Robin Vos, Erik Verschuuren, Andrew Fisher, Gerdt Riise, Lennart Hansson, Martin Iversen, Pekka Hämmäinen, Hans Wedel, Jacqueline Smits, Jens Gottlieb, Are M. Holm
  
  European Respiratory Journal 51 (2) 1701330; DOI: 10.1183/13993003.01330-2017 Published 14 February 2018

Perspective

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Immunotherapy: a new standard of care in thoracic malignancies?
Adrien Costantini, Marta Grynovska, Francesca Lucibello, Jorge Moisés, Franck Pagès, Ming S. Tsao, Frances A. Shepherd, Hasna Bouchaab, Marina Garassino, Joachim G.J.V. Aerts, Julien Mazières, Michele Mondini, Thierry Berghmans, Anne-Pascale Meert, Jacques Cadranel

European Respiratory Journal 51 (2) 1702072; DOI: 10.1183/13993003.02072-2017 Published 14 February 2018

Series

Physiology in respiratory medicine
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  Ventilatory response to exercise in cardiopulmonary disease: the role of chemosensitivity and dead space
  Jason Weatherald, Caroline Sattler, Gilles Garcia, Pierantonio Laveneziana
  
  European Respiratory Journal 51 (2) 1700860; DOI: 10.1183/13993003.00860-2017 Published 7 February 2018

Reviews

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Tracheal replacement
Harry Etienne, Dominique Fabre, Abel Gomez Caro, Frederic Kolb, Sacha Mussot, Olaf Mercier, Delphine Mitilian, Francois Stephan, Elie Fadel, Philippe Dartevelle

European Respiratory Journal 51 (2) 1702211; DOI: 10.1183/13993003.02211-2017 Published 14 February 2018
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Living with breathlessness: a systematic literature review and qualitative synthesis
Ann Hutchinson, Natalie Barclay-Klingle, Kathleen Galvin, Miriam J. Johnson

European Respiratory Journal 51 (2) 1701477; DOI: 10.1183/13993003.01477-2017 Published 21 February 2018

Agora

Research letters
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  Airway infection, systemic inflammation and lung clearance index in children and adults with cystic fibrosis
  Katherine O'Neill, Judy M. Bradley, Alastair Reid, Damian G. Downey, Jacqueline Rendall, John McCaughan, John E. Moore, Michael M. Tunney, J. Stuart Elborn
  
  European Respiratory Journal 51 (2) 1701704; DOI: 10.1183/13993003.01704-2017 Published 31 January 2018
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  Role of a prolonged inpatient admission when evaluating children with problematic severe asthma
  Prasad Nagakumar, Nikki Gambir, Nina Sanghani, Pippa Hall, Angela Jamalzadeh, Frances Beresford, Sejal Saglani, Andrew Bush, Louise Fleming
  
  European Respiratory Journal 51 (2) 1701061; DOI: 10.1183/13993003.01061-2017 Published 31 January 2018
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  A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis
  Russell R. Kempker, M. Tobias Heinrichs, Ketino Nikolaishvili, Irina Sabulua, Nino Bablishvili, Shota Gogishvili, Zaza Avaliani, Brent P. Little, Adam Bernheim, Hartmut Derendorf, Henry M. Blumberg, Sergo Vashakidze, Charles A. Peloquin
  
  European Respiratory Journal 51 (2) 1702166; DOI: 10.1183/13993003.02166-2017 Published 7 February 2018
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  Detection of human cytomegalovirus in bronchoalveolar lavage of intensive care unit patients
  Andrea Vergara, Catia Cilloniz, Nestor Luque, Carolina Garcia-Vidal, Javier Tejero, Rafael Perelló, Carmen María Lucena, Antoni Torres, María Angeles Marcos
  
  European Respiratory Journal 51 (2) 1701332; DOI: 10.1183/13993003.01332-2017 Published 7 February 2018
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  Asthma treatment impacts time to pregnancy: evidence from the international SCOPE study
  Luke E. Grzeskowiak, Lisa G. Smithers, Jessica A. Grieger, Tina Bianco-Miotto, Shalem Y. Leemaqz, Vicki L. Clifton, Lucilla Poston, Lesley M. McCowan, Louise C. Kenny, Jenny Myers, James J. Walker, Robert J Norman, Gus A. Dekker, Claire T. Roberts
  
  European Respiratory Journal 51 (2) 1702035; DOI: 10.1183/13993003.02035-2017 Published 14 February 2018
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  Dyspnoea modifies the recognition of fearful expressions by healthy humans
  Fabien Vinckier, Capucine Morélot-Panzini, Thomas Similowski
  
  European Respiratory Journal 51 (2) 1702253; DOI: 10.1183/13993003.02253-2017 Published 14 February 2018
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  Sex differences and factors influencing the duration of the QT interval in patients on anti-tuberculosis therapy
  Gerardo Alvarez-Uria, Manoranjan Midde
  
  European Respiratory Journal 51 (2) 1702368; DOI: 10.1183/13993003.02368-2017 Published 21 February 2018
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  Relapse-free cure from multidrug-resistant tuberculosis in Germany
  Jan Heyckendorf, Frank van Leth, Barbara Kalsdorf, Ioana D. Olaru, Gunar Günther, Helmut J.F. Salzer, Elena Terhalle, Thierry Rolling, Georg Glattki, Marius Müller, Maren Schuhmann, Korkut Avsar, Christoph Lange
  
  European Respiratory Journal 51 (2) 1702122; DOI: 10.1183/13993003.02122-2017 Published 21 February 2018
Correspondence
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  Inhaled corticosteroids and increased microbial load in COPD: potential role of epithelial adhesion molecules
  Sukhwinder Singh Sohal
  
  European Respiratory Journal 51 (2) 1702257; DOI: 10.1183/13993003.02257-2017 Published 31 January 2018
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  Variation in incidence trends of malignant pleural mesothelioma in Europe
  Mohammed Ahmed, Antoinette Flannery, Irfan Mujammil, David Breen
  
  European Respiratory Journal 51 (2) 1702384; DOI: 10.1183/13993003.02384-2017 Published 7 February 2018
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  Should gatifloxacin be included in the model list of essential medicines?
  Chen-Yuan Chiang, Arnaud Trébucq, Alberto Piubello, Hans L. Rieder, Armand Van Deun
  
  European Respiratory Journal 51 (2) 1702329; DOI: 10.1183/13993003.02329-2017 Published 7 February 2018
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  Tuberculosis re-treatment after exclusion of rifampicin resistance
  Chen-Yuan Chiang, Arnaud Trébucq
  
  European Respiratory Journal 51 (2) 1702282; DOI: 10.1183/13993003.02282-2017 Published 14 February 2018
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  Progress in the management of IPF-related acute exacerbations: a goal for patients, respirologists and intensivists
  François Vincent, Hilario Nunes, Stéphane Gaudry
  
  European Respiratory Journal 51 (2) 1702419; DOI: 10.1183/13993003.02419-2017 Published 21 February 2018
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  Progress in the management of IPF-related acute exacerbations: a goal for patients, respirologists and intensivists
  Ganesh Raghu
  
  European Respiratory Journal 51 (2) 1800113; DOI: 10.1183/13993003.00113-2018 Published 21 February 2018

Author Corrections

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“Global strategy for asthma management and prevention: GINA executive summary.” E.D. Bateman, S.S. Hurd, P.J. Barnes, J. Bousquet, J.M. Drazen, J.M. FitzGerald, P. Gibson, K. Ohta, P. O'Byrne, S.E. Pedersen, E. Pizzichini, S.D. Sullivan, S.E. Wenzel and H.J. Zar. Eur Respir J 2008; 31: 143–178.
European Respiratory Journal 51 (2) 0751387; DOI: 10.1183/13993003.51387-2007 Published 31 January 2018
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“Pneumocystosis revealing immunodeficiency secondary to TERC mutation.” Raphael Borie, Caroline Kannengiesser, Flore Sicre de Fontbrune, David Boutboul, Laure Tabeze, Florence Brunet-Possenti, Elodie Lainey, Marie Pierre Debray, Aurélie Cazes and Bruno Crestani. Eur Respir J 2017; 50: 1701443.
European Respiratory Journal 51 (2) 1751443; DOI: 10.1183/13993003.51443-2017 Published 21 February 2018
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“RESPIRE: breathing new life into bronchiectasis.” Sanjay H. Chotirmall and James D. Chalmers. Eur Respir J 2018; 51: 1702444.
European Respiratory Journal 51 (2) 1752444; DOI: 10.1183/13993003.52444-2017 Published 1 March 2018

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Table of Contents

Electronic resources

Editorials

Original Articles

Sleep

Physiology

COPD

Bronchiectasis

Pulmonary hypertension

Basic science and interstitial lung disease

Interstitial lung disease

Asthma

Asthma and allergy

Asthma and paediatrics

Paediatrics

Tuberculosis

Infection

Lung function

Rare lung disease

Perspective

Series

Physiology in respiratory medicine

Reviews

Agora

Research letters

Correspondence

Author Corrections

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