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Glutathione level in community-acquired pneumonia patients

Natalja Voskresenska, Julija Voicehovska, Sergejs Babikovs, Vladimirs Voicehovskis, Aivars Lejnieks, Andrejs Skesters, Alise Silova
European Respiratory Journal 2017 50: PA988; DOI: 10.1183/1393003.congress-2017.PA988
Natalja Voskresenska
1Internal diseases department, Riga Stradins university, Riga, Latvia
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Julija Voicehovska
1Internal diseases department, Riga Stradins university, Riga, Latvia
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Sergejs Babikovs
1Internal diseases department, Riga Stradins university, Riga, Latvia
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Vladimirs Voicehovskis
1Internal diseases department, Riga Stradins university, Riga, Latvia
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Aivars Lejnieks
1Internal diseases department, Riga Stradins university, Riga, Latvia
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Andrejs Skesters
2Biochemical Laboratory, Riga Stradins university, Riga, Latvia
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Alise Silova
2Biochemical Laboratory, Riga Stradins university, Riga, Latvia
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Abstract

Glutathione, in its thiol-reduced form (GSH), is the most abundant antioxidant in the airway epithelial lining fluid. It acts as a vital intra- and extracellular antioxidant protecting oxidative/nitrosative stress, interceding the pro-inflammatory processes in the lungs.

Aim: Relationship between pneumonia severity and GSH level have been studied.

Methods: A case-conrol study took place at P. Stradins Clinical University hospital, Riga, Latvia. Community-acquired pneumonia (CAP) patients with no underlying chronic heart failure (n=32), both males and females of average age 69,0+7,2 and healthy control patients matched for age (n=20) were recruited. CURB 65 (confusion, uremia, respiratory rate, BP, age ≥ 65 years) score was used for CAP severity assessment. The level of plasma GSH was determined. CAP clinical pattern was followed up for 3 weeks.

Results: Being compared to control group, GSH level was reduced in CAP patients (mean GSH was 1.12+ 0,22 mmol/L versus 1.60+0,16 mmol/L accordingly). There was no correlation between GSH level and CAP severity by CURB65. However, in 8 patients respiratory failure (RF) has developed. All the patients, in whom RF has developed, demonstrated GSH level below 1,1 mmol/L on admission.

Conclusions: A low concentration of plasma GSH indicating low antioxidant capacity could act as a marker for inflammation-related OS in CAP patients for its management and/or risk of complications stratification.

  • Copyright ©the authors 2017
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Glutathione level in community-acquired pneumonia patients
Natalja Voskresenska, Julija Voicehovska, Sergejs Babikovs, Vladimirs Voicehovskis, Aivars Lejnieks, Andrejs Skesters, Alise Silova
European Respiratory Journal Sep 2017, 50 (suppl 61) PA988; DOI: 10.1183/1393003.congress-2017.PA988

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Glutathione level in community-acquired pneumonia patients
Natalja Voskresenska, Julija Voicehovska, Sergejs Babikovs, Vladimirs Voicehovskis, Aivars Lejnieks, Andrejs Skesters, Alise Silova
European Respiratory Journal Sep 2017, 50 (suppl 61) PA988; DOI: 10.1183/1393003.congress-2017.PA988
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