Abstract
Introduction: Acute exacerbations causes deterioration in quality of life, pulmonary and muscle functions of COPD patients. Exercise taken during an acute exacerbation can improve quality of life. However, few studies evaluated the influence of short aerobic in inflammatory markers. Objective:To evaluate if there is an increase in inflammatory markers after short-term aerobic exercise.
Methods: We randomized 26 patients hospitalized for COPD exacerbation in two groups. The intervention group performed short aerobic exercise during all hospitalization stay and the control group. The inflammatory markers and Saint George’s Respiratory Questionnaire of all patients were evaluated after 48 hours of hospitalization and after one month of discharge. We also assessed the inflammatory markers before and after short aerobic exercise. Short aerobic exercise program was performed with mean velocity 1.8±1.6 Km/h, with a treadmill during 15 minutes.
Results: No significant increase in inflammatory markers was observed before and after short-term aerobic exercise (TNF-α 2.59±0.42pg/mlvs1.43±0.15pg/ml; p=0.13; IL-6 4.00±0.64mg/lvs0.28±1.04mg/L; p=0.17 e CRP 7.53±9.69mg/Lvs0.13±10.08mg/l; p=0.824). We did not identify increase in inflammatory markers after one month of discharge in both groups. We observed a statistically significant decrease in symptoms of SGRQ in the intervention group when compared to control group after one month of discharge (50.5±4.5vs63.8±4.7; p= 0,023).
Conclusion: This study showed that patients who performed an aerobic exercise during hospitalization had better symptoms without increase of inflammatory markers.
- Copyright ©the authors 2017