Abstract
Aim: to study the influence of Tmz on quality of life and functional status of pts with IPAH, according by questionnaire SF36 and Holter ECG monitoring
In this study we included 18 pts with IPAH: 17 women/1 man, mean age 44,55 ± 8,4 yo. Diagnosis IPAH was confirmed by complex diagnostic proces. All pts had a common complain of angina-like symptoms. No signs of ischemic heart disease or left main coronary artery compression were not found by CT scan. On the 1st step of diagnostic examination we made the 6MWT, the 2 step we found the pts with ischemic changes on Holter ECG monitoring. In identifying the changes in the end of part of ventricular complex QRS was prescribed Tmz. After 6 months of follow-up examination, which included: Holter ECG and 6-MWT. All of patients completed a questionnaire - SF 36
To 24 week of Tmz treatment the distance in 6-MWT did't increase (416.3±99,6m). In IPAH pts before therapy Tmz mean/max/min HR were 72,5±8,7/120,6±19,2/53,9±7,2 per min respectively. In group after therapy Tmz HRmean was 70,1±4,9 per min, HRmax was 114,6±12,1 per min and HRmin were 52,3±6,6 per min. Significant arrhythmias were not observed. In 4 patients (36.36%) were identified changes in the end part of ventricular complex QRS, after 6 months treatment Tmz change the end of part of QRS is not registered. We analyzed the questionnaire SF36 compared to before and after treatment Tmz: improvement in general health (p=0.02), physical role functioning (P=0.02), improvement index bodily pain (p = 0, 01), Vitality (p=0.02), mental health (p=0.01)
Conclusion: Tmz might be considered as additional treatment option in IPAH pts as it improves quality of life in patients with IPAH, complaining of chest pain
- Copyright ©the authors 2017