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Exploring the relationship between alpha-1-antitrypsin deficiency and persistent airflow limitation in severe asthma

Guillermo Menga, Daniel Colodenco, Magdalena Mercuri Guillemi, Luciana Montoto Piazza, Juan Rodríguez Moncalvo, Martín Fernández
European Respiratory Journal 2017 50: PA4465; DOI: 10.1183/1393003.congress-2017.PA4465
Guillermo Menga
1María Ferrer Hospital, Buenos Aires, Argentina
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Daniel Colodenco
1María Ferrer Hospital, Buenos Aires, Argentina
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Magdalena Mercuri Guillemi
1María Ferrer Hospital, Buenos Aires, Argentina
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Luciana Montoto Piazza
1María Ferrer Hospital, Buenos Aires, Argentina
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Juan Rodríguez Moncalvo
1María Ferrer Hospital, Buenos Aires, Argentina
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Martín Fernández
1María Ferrer Hospital, Buenos Aires, Argentina
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Abstract

Background: Persistent airflow limitation is common among patients with severe asthma, but its pathogenesis has not been fully clarified. Severe alpha-1-antitrypsin deficiency (AATD) is a risk factor for chronic airflow limitation and emphysema, and partially deficient phenotypes have been associated with an accelerated decline in lung function.

Aims: To estimate frequency of AATD in patients with persistent airflow limitation in severe asthma.

Methods: 207 patients with severe asthma and persistent airflow limitation (FEV1 <75% and reduced FEV1/FVC ratio) were included between 2013 and 2016.

All patients underwent determination of serum AAT levels by nephelometry. In those patients with serum levels under 120 mg/dL an allele specific genotyping assay was performed to detect the most prevalent variants (Z and S).

Statistical analysis was made with PAWS Statistics 18 © software.

Results: We found female predominance (64.2%), mean age: 56 years (range 23-70), 14.5% of active smokers, Mean alpha-1 antitrypsin was 137 mg/dL. Genotyping assay was made in 20.2% samples that were under cut-off. Deficient patients MZ=3 (1.45%), SS=1 (0.49%), and MS=12 (5.79%).

Conclusions: Prevalence of AATD in patients with severe asthma and airflow limitation is low. Routine assessment of AATD is not supported by this data therefore further studies are needed.

  • Copyright ©the authors 2017
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Exploring the relationship between alpha-1-antitrypsin deficiency and persistent airflow limitation in severe asthma
Guillermo Menga, Daniel Colodenco, Magdalena Mercuri Guillemi, Luciana Montoto Piazza, Juan Rodríguez Moncalvo, Martín Fernández
European Respiratory Journal Sep 2017, 50 (suppl 61) PA4465; DOI: 10.1183/1393003.congress-2017.PA4465

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Exploring the relationship between alpha-1-antitrypsin deficiency and persistent airflow limitation in severe asthma
Guillermo Menga, Daniel Colodenco, Magdalena Mercuri Guillemi, Luciana Montoto Piazza, Juan Rodríguez Moncalvo, Martín Fernández
European Respiratory Journal Sep 2017, 50 (suppl 61) PA4465; DOI: 10.1183/1393003.congress-2017.PA4465
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