Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Monitoring adherence to treatment regimen of inhaled medication use in a clinical trial with an investigational eFlow nebulizer (eTrack)

Carola Fuchs, Matthias Brosig, Matthias Finke, David Fiebig, Pravin Soni, Ahmet Tutuncu, Rod Saponjic, Martin Knoch
European Respiratory Journal 2017 50: PA2781; DOI: 10.1183/1393003.congress-2017.PA2781
Carola Fuchs
1PARI GmbH, Starnberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias Brosig
2PARI Pharma GmbH, Starnberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias Finke
2PARI Pharma GmbH, Starnberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Fiebig
1PARI GmbH, Starnberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pravin Soni
3Patara Pharma, LLC, San Diego, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahmet Tutuncu
3Patara Pharma, LLC, San Diego, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rod Saponjic
3Patara Pharma, LLC, San Diego, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Knoch
2PARI Pharma GmbH, Starnberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Patient adherence to the protocol in clinical trials is a critical factor in determining the outcome of the trial.

An investigational eFlow nebulizer was used with an eTrack controller featuring adherence-monitoring capability (PARI Pharma, Germany) to deliver drug to the lungs via inhalation and to objectively monitor adherence. The inhalation data were available via the PARItrack web portal and allowed evaluation and graphical visualization of each patient’s adherence.

The clinical trial involved 10 patients who self-administered drug in their homes twice a day for 6 weeks. The eTrack controller automatically transferred data of each nebulization via a Bluetooth connection to a 2netHub (Qualcomm) and via GSM to a server. The data could be accessed through the PARItrack web portal. The clinical trial nurses, investigators and CRO could remotely monitor adherence and an alert system was established for information on missed inhalations. This allowed individual adherence issues to be addressed immediately and corrective actions to be implemented to ensure ongoing adherence.

This setup resulted in a high adherence rate over the duration of the clinical trial. The overall mean adherence rate was 96 %. Seven out of ten patients had an adherence rate of 100 %, two had 95 %, and one had 64 %. This compares with a reported adherence rate of 78 % in the first 4 weeks of another clinical trial using a monitoring nebulizer without remote data access and intervention [Fuchs et al. ECFC 2011].

The high adherence rates achieved in this study demonstrate the utility of remote monitoring and immediate intervention to achieve good adherence in a clinical trial.

  • Copyright ©the authors 2017
Previous
Back to top
Vol 50 Issue suppl 61 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Monitoring adherence to treatment regimen of inhaled medication use in a clinical trial with an investigational eFlow nebulizer (eTrack)
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Monitoring adherence to treatment regimen of inhaled medication use in a clinical trial with an investigational eFlow nebulizer (eTrack)
Carola Fuchs, Matthias Brosig, Matthias Finke, David Fiebig, Pravin Soni, Ahmet Tutuncu, Rod Saponjic, Martin Knoch
European Respiratory Journal Sep 2017, 50 (suppl 61) PA2781; DOI: 10.1183/1393003.congress-2017.PA2781

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Monitoring adherence to treatment regimen of inhaled medication use in a clinical trial with an investigational eFlow nebulizer (eTrack)
Carola Fuchs, Matthias Brosig, Matthias Finke, David Fiebig, Pravin Soni, Ahmet Tutuncu, Rod Saponjic, Martin Knoch
European Respiratory Journal Sep 2017, 50 (suppl 61) PA2781; DOI: 10.1183/1393003.congress-2017.PA2781
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Cognitive task analysis of flexible bronchoscopy for the design of simulation-based training
  • “NIVSIM” a simulation based education (SBE) intervention to improve the quality of care delivered for patients receiving acute non-invasive ventilation (NIV)
  • Machine learning tools to detect COPD patients with Excessive Sedentary living and Physical Inactivity
Show more Medical education, web and internet

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society