Abstract
Background: Recent investigations have highlighted the role of obesity and metabolic biomarkers on lung function.
Aims: We investigated the effects of Body Mass Index (BMI) and serum adipokines on lung function and assessed further whether variation in the ADIPOQ, ADIPOR1, and ADIPOR2 genes influences lung function in young males.
Methods: A cross-sectional study of 413 18-year old Cypriot males was used. BMI was recorded and spirometry was performed by trained professionals. Leptin and adiponectin serum levels were measured and genotype analysis was done for different SNPs in the ADIPOQ, ADIPOR1, and ADIPOR2 genes. Multiple linear regression models were used to test for associations of BMI, leptin, adiponectin, and genetic variants with lung function, adjusting for smoking and BMI.
Results: FEV1 % predicted and FVC % predicted increased significantly with a unit increase in BMI (β=0.26, p=0.05 and β=0.46, p<0.01, respectively) while FEV1/FVC% decreased but not significantly (β=-1.00, p=0.13). Leptin levels were inversely associated with FEV1 % predicted and FVC % predicted (β=-1.34, p<0.01 and β=-1.36, p<0.01, respectively) but not with FEV1/FVC % predicted (β=0.59, p=0.81). There was no association with adiponectin levels but rs266729 in ADIPOQ (β=2.22, p=0.04) and rs7975600 in ADIPOR2 (β=3.09, p<0.01) were associated with FEV1 % predicted. Rs1501299 in ADIPOQ (β=3.13, p=0.01) and rs7975600 in ADIPOR2 (β=2.62, p=0.04) were associated with FVC % predicted, and rs1501299 in ADIPOQ (β=-2.01, p=0.01) with FEV1/FVC%.
Conclusion: Associations of lung function with BMI, leptin, and several variants in the adiponectin pathway suggest that metabolic pathways may play a role in lung function.
- Copyright ©the authors 2017