Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Cortical disorders and muscle weakness in COPD: impact of neuromodulation on intracortical inhibition

Vincent Cabibel, Benjamin Le Toullec, Nicolas Oliver, Nelly Héraud, Alain Varray
European Respiratory Journal 2017 50: OA3433; DOI: 10.1183/1393003.congress-2017.OA3433
Vincent Cabibel
15 Santé / EuroMov, Lodève, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Le Toullec
2EuroMov, Montpellier, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicolas Oliver
35 Santé, Lodève, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nelly Héraud
35 Santé, Lodève, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alain Varray
2EuroMov, Montpellier, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
Loading

Abstract

Muscle weakness is a major issue. An increased intracortical inhibition and a lack in central motor drive have been recently reported in COPD (Alexandre et al., PLoS ONE 9:e100961, 2014). Therefore the aim of this study was to investigate the possibility to counterbalance this phenomenon by using non-invasive cortical neuromodulation.

Ten COPD (GOLD II-IV) and nine matched control subjects were randomly assigned to undergo 10min/2mA anodal (intervention) or sham high-definition transcranial direct-current stimulation (HD-tDCS) of the dominant primary motor cortex (M1) in a double-blind design with at least 72h between each session. Strength of the vastus lateralis (VL), neuromuscular properties, motor potentials (MEP) and cortical silent period (CSP) evoked by transcranial magnetic stimulation from the dominant M1 towards the contralateral VL were measured before and after neuromodulatory intervention.

The intervention by anodal HD-tDCS resulted in decreased CSP (intracortical inhibition) while no difference was present in the control group (see Figure). However, strength and MEP (cortical excitability) were not affected by the neuromodulatory intervention.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

This study showed that COPD patients exhibited reversible increased intracortical inhibition. These preliminary results are a step towards a better understanding of the pathophysiology of cortical disorders in muscle weakness in COPD patients.

  • Copyright ©the authors 2017
Previous
Back to top
Vol 50 Issue suppl 61 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Cortical disorders and muscle weakness in COPD: impact of neuromodulation on intracortical inhibition
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Cortical disorders and muscle weakness in COPD: impact of neuromodulation on intracortical inhibition
Vincent Cabibel, Benjamin Le Toullec, Nicolas Oliver, Nelly Héraud, Alain Varray
European Respiratory Journal Sep 2017, 50 (suppl 61) OA3433; DOI: 10.1183/1393003.congress-2017.OA3433

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Cortical disorders and muscle weakness in COPD: impact of neuromodulation on intracortical inhibition
Vincent Cabibel, Benjamin Le Toullec, Nicolas Oliver, Nelly Héraud, Alain Varray
European Respiratory Journal Sep 2017, 50 (suppl 61) OA3433; DOI: 10.1183/1393003.congress-2017.OA3433
Reddit logo Technorati logo Twitter logo Connotea logo Facebook logo Mendeley logo

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • CLE-test with cold air as provocation factor – a feasibility study
  • Structural characteristics of a novel catheter for esophageal pressure monitoring
  • Implementation of a human mainstream capnograph to rats using 3D-printed adapter
Show more Clinical respiratory physiology, exercise and functional imaging

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society