Two-year follow-up after endobronchial coil treatment in emphysema: results from the REVOLENS study

Gaëtan Deslée; Sylvie Leroy; Jeanne Marie Perotin; Hervé Mal; Hervé Dutau; Arnaud Bourdin; Jean Michel Vergnon; Christophe Pison; Romain Kessler; Vincent Jounieaux; Mathieu Salaün; Armelle Marceau; Sandra Dury; Jonathan Benzaquen; Margaux Bonnaire; Sylvain Dukic; Coralie Barbe; Charles Hugo Marquette

doi:10.1183/13993003.01740-2017

Tables

Supplementary Materials

TABLE 1

Changes from baseline at 6 and 12 months, and 2 years after coil treatment

	Overall group			Patients who attended the 2-year follow-up visit
	Baseline	6 months	12 months	Baseline	6 months	12 months	2 years
Subjects n	50	47	44	32	32	32	32
6MWT m	300±112	+18±81; p=0.14	−2±87; p=0.88	323±105	+25±67; p=0.048	+15±77; p=0.29	+6±84; p=0.56
≥54 m		16/44 (36%)	8/43 (19%)		12/32 (38%)	7/32 (22%)	7/28 (25%)
≥25 m		19/44 (43%)	12/43 (28%)		15/32 (47%)	11/32 (34%)	11/28 (39%)
mMRC scale	3±0.7	−0.5±0.9; p=0.0002	−0.5±1; p=0.006	2.9±0.6	−0.7±0.9; p=0.0003	−0.7±1; p=0.0007	−0.4±1; p=0.06
≥1		19/47 (40%)	19/41 (46%)		15/32 (47%)	15/30 (50%)	13/30 (43%)
FEV₁ L	0.75±0.25	+0.05±0.14; p=0.02	+0.04±0.15; p=0.1	0.78±0.26	+0.04±0.15; p=0.15	+0.03±0.14; p=0.21	0±0.16; p=0.92
≥100 mL		17/47 (36%)	12/44 (27%)		12/32 (38%)	8/32 (25%)	8/32 (25%)
≥10%		21/47 (45%)	14/44 (32%)		14/32 (44%)	9/32 (28%)	12/32 (38%)
RV L	6.2±0.86	−0.53±0.72; p<0.0001	−0.47±0.68; p<0.0001	5.92±0.74	−0.46±0.51; p<0.0001	−0.39±0.68; p=0.003	−0.28±0.69; p=0.03
≥350 mL		29/47 (62%)	25/44 (57%)		19/32 (59%)	18/32 (56%)	14/32 (44%)
SGRQ (0–100)	60.8±12.8	−11.1±16.1; p<0.0001	−9.1±15.9; p=0.0006	57.9±12.3	−12.3±17.6; p=0.0005	−11.5±16.4; p=0.0006	−7.9±14.5; p=0.005
≥4 points		32/45 (71%)	26/42 (62%)		24/31 (77%)	21/30 (70%)	20/31 (65%)
≥8 points		28/45 (62%)	21/42 (50%)		21/31 (68%)	16/30 (53%)	16/31 (52%)

Data are presented as mean±sd or number (%), unless otherwise stated. The percentage of patients reaching the minimal clinically important difference for each variable is indicated. Changes from baseline were assessed by paired t-tests. 6MWT: 6-min walking test; mMRC : modified Medical Research Council dyspnoea scale; FEV₁: forced expiratory volume 1 s; RV: residual volume; SGRQ: Saint George's Respiratory Questionnaire.