Extract
Severe emphysema is a difficult to treat condition with limited efficacy of currently available treatments. Endobronchial coil treatment (ECT) is a minimally invasive endobronchial treatment which consists of placing shape-memory nitinol coils in emphysematous lobes to enhance lung recoil and reduce lung hyperinflation at rest and during exercise [1, 2]. Randomised studies demonstrated an improvement in exercise capacity, lung function and quality of life, and showed an acceptable safety profile at 1 year [3–6]. However, to our best knowledge, longer term safety and effectiveness results beyond 1 year have not been reported thus far.
Abstract
In severe emphysema, endobronchial coils improve quality of life with an acceptable safety profile at 2 years http://ow.ly/eVlg30gKrPE
Acknowledgements
Author's contributions: G. Deslée had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of data analysis. Study concept and design: G. Deslée, C.H. Marquette, C. Barbe; acquisition of data: G. Deslée, S. Leroy, J.M. Perotin, H. Mal, H. Dutau, A. Bourdin, J.M. Vergnon, C. Pison, R. Kessler, V. Jounieaux, M. Salaün, A. Marceau, S. Dury, J. Benzaquen, S. Dukic, M. Bonnaire, C.H. Marquette; analysis and interpretation of data: G. Deslée, C.H. Marquette, C. Barbe; drafting of the manuscript: G. Deslée, C.H. Marquette, S. Leroy, J.M. Perotin; critical revision of the manuscript for important intellectual content: G. Deslée, S. Leroy, J.M. Perotin, H. Mal, H. Dutau, A. Bourdin, J.M. Vergnon, C. Pison, R. Kessler, V. Jounieaux, M. Salaün, A. Marceau, S. Dury, J. Benzaquen, M. Bonnaire, S. Dukic, C. Barbe, C.H. Marquette; statistical analysis: C. Barbe; study supervision: G. Deslée.
Members of the REVOLENS Study Group: The members of the REVOLENS Study Group include all authors and Hervé Vallerand, François Lebargy, Claire Launois (Hôpital Universitaire de Reims), Johanna Pradelli, Matthieu Buscot, Celine Sanfiorenzo, Sylvie Korzeniewski, Andrea Mazzetta, Jennifer Griffonnet, Ariane Guillemart, Demosthenes Makris (Hôpital Universitaire de Nice), Marie Christine Dombret, Frédérique Servin, Marie Pierre Debray (Hôpital Universitaire Bichat, Paris), Sophie Laroumagne, Fabienne Bregeon, Carine Gomez, Philippe Astoul (Hôpital Universitaire de Marseille), Nathalie Lesavre (Centre d'Investigation Clinique 1409, AP-HM, Marseille), Jean Pierre Mallet, Anne Sophie Gamez, Philippe Tarodo, Christophe Brousse, Clément Broissin (Hôpital Universitaire de Montpellier), Yoann Thibout, Fabrice Di Palma, Frédéric Costes (Hôpital Universitaire de Saint Etienne), Amandine Briault, François Arbib, Emilie Reymond (Hôpital Universitaire de Grenoble), Michele Porzio, Benjamin Renaud-Picard (Hôpital Universitaire de Strasbourg), Bénédicte Toublanc, Géraldine François (Hôpital Universitaire d'Amiens), Luc Thiberville, Antoine Cuvelier, Samy Lachkar (Hôpital Universitaire de Rouen), Delphine Gras (Monitoring team, Hôpital Universitaire de Reims), Philippe Benoit (Pharmacie, Hôpital Universitaire de Reims), Annick Leclainche, Damien Jolly (Pôle recherche et innovation, Hôpital Universitaire de Reims). Data and Safety Management Board: François Fourrier, Eric Hachulla, Nicolas Roche, Daniel Dusser. The collaborators did not receive any compensation for their contribution.
Footnotes
This study is registered at ClinicalTrials.gov with identifier number NCT01822795.
Support statement: The REVOLENS Study was supported by an academic grant from the French Ministry of Health (Direction Générale de l'Offre de Soins, PSTIC-2012) which required a randomised trial design. The coils were purchased from the manufacturer (PneumRx/BTG, Mountain View, CA, USA) which had no involvement in the study design and analysis of the data. PneumRx/BTG provided a financial support for the follow-up assessment after 1 year. The French Ministry of Health had full access to the results of the study, but had no involvement in the design and conduct of the study, collection, management, analysis, and interpretation of the data, preparation, review, or approval of the manuscript, and decision to submit the manuscript for publication. Funding information for this article has been deposited with the Crossref Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received July 17, 2017.
- Accepted September 19, 2017.
- Copyright ©ERS 2017
