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Table of Contents

01 November 2017; volume 50, issue 5

Electronic Resources

  • You have accessRestricted access
    ERJ November Podcast: ERS statement on the diagnosis and treatment of pulmonary disease caused by α1-antitrypsin deficiency
    European Respiratory Journal 50 (5) 17E5005; DOI: 10.1183/13993003.E5005-2017 Published 30 November 2017

Editorials

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    Action levels for indoor radon: different risks for the same lung carcinogen?
    Alberto Ruano-Ravina, Karl T. Kelsey, Alberto Fernández-Villar, Juan M. Barros-Dios
    European Respiratory Journal 50 (5) 1701609; DOI: 10.1183/13993003.01609-2017 Published 9 November 2017
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    Digital health to end tuberculosis in the Sustainable Development Goals era: achievements, evidence and future perspectives
    Dennis Falzon, Giovanni Battista Migliori, Ernesto Jaramillo, Karin Weyer, Guy Joos, Mario Raviglione on behalf of the Global Task Force on digital health for TB
    European Respiratory Journal 50 (5) 1701632; DOI: 10.1183/13993003.01632-2017 Published 9 November 2017
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    Closing the gap in surveillance of tuberculosis and HIV co-infection: a European perspective on the need for clinician–public health alliances
    Marieke J. van der Werf, Giovanni Sotgiu, Masoud Dara
    European Respiratory Journal 50 (5) 1701758; DOI: 10.1183/13993003.01758-2017 Published 16 November 2017
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    Cardiac safety of bedaquiline: a systematic and critical analysis of the evidence
    Emanuele Pontali, Giovanni Sotgiu, Simon Tiberi, Lia D'Ambrosio, Rosella Centis, Giovanni B. Migliori
    European Respiratory Journal 50 (5) 1701462; DOI: 10.1183/13993003.01462-2017 Published 16 November 2017
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    COPD: algorithms and clinical management
    Rosa Faner, Alvar Agustí
    European Respiratory Journal 50 (5) 1701733; DOI: 10.1183/13993003.01733-2017 Published 2 November 2017
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    Peripheral eosinophil count as a biomarker for the management of COPD: not there yet
    Klaus F. Rabe, Bianca Beghé, Leonardo M. Fabbri
    European Respiratory Journal 50 (5) 1702165; DOI: 10.1183/13993003.02165-2017 Published 22 November 2017
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    Genetic studies as a tool for identifying novel potential targets for treatment of COPD
    Ani Manichaikul, Jennifer N. Nguyen
    European Respiratory Journal 50 (5) 1702042; DOI: 10.1183/13993003.02042-2017 Published 30 November 2017
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    Reprogramming of cellular metabolism: driver for airway remodelling in COPD?
    Pieter S. Hiemstra, Anne M. van der Does
    European Respiratory Journal 50 (5) 1702197; DOI: 10.1183/13993003.02197-2017 Published 30 November 2017
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    Multi-trigger and viral wheeze: describing symptoms or defining diseases?
    Daan Caudri
    European Respiratory Journal 50 (5) 1701283; DOI: 10.1183/13993003.01283-2017 Published 2 November 2017
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    Elucidating progression of early cystic fibrosis lung disease
    Kathryn Ramsey, Felix Ratjen, Philipp Latzin
    European Respiratory Journal 50 (5) 1701916; DOI: 10.1183/13993003.01916-2017 Published 9 November 2017
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    Inflammation, age and changing microbiology: the search for causation in the cystic fibrosis airways
    Geraint B. Rogers
    European Respiratory Journal 50 (5) 1701935; DOI: 10.1183/13993003.01935-2017 Published 16 November 2017
  • European lung corner

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      Plain packaging of tobacco products in the European Union: an EU success story?
      Constantine Vardavas, Filippos T. Filippidis, Brian Ward, Marine Faure, Carlos Jimenez-Ruiz, Christina Gratziou, Paraskevi Katsaounou, Francisco Lozano, Panagiotis Behrakis, Cornel Radu-Loghin on behalf of the European Respiratory Society (ERS) Tobacco Control Committee, on behalf of the European Network for Smoking and Tobacco Prevention (ENSP) Scientific Committee
      European Respiratory Journal 50 (5) 1701232; DOI: 10.1183/13993003.01232-2017 Published 22 November 2017

From the Museum

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    The Art of Breathing: Apnoea
    Tom Kotsimbos, Gary P. Anderson
    European Respiratory Journal 50 (5) 1705005; DOI: 10.1183/13993003.05005-2017 Published 30 November 2017

ERS Official Documents

  • ERS statements

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      An official European Respiratory Society statement: pulmonary haemodynamics during exercise
      Gabor Kovacs, Philippe Herve, Joan Albert Barbera, Ari Chaouat, Denis Chemla, Robin Condliffe, Gilles Garcia, Ekkehard Grünig, Luke Howard, Marc Humbert, Edmund Lau, Pierantonio Laveneziana, Gregory D. Lewis, Robert Naeije, Andrew Peacock, Stephan Rosenkranz, Rajeev Saggar, Silvia Ulrich, Dario Vizza, Anton Vonk Noordegraaf, Horst Olschewski
      European Respiratory Journal 50 (5) 1700578; DOI: 10.1183/13993003.00578-2017 Published 22 November 2017
    • You have accessRestricted access
      European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency
      Marc Miravitlles, Asger Dirksen, Ilaria Ferrarotti, Vladimir Koblizek, Peter Lange, Ravi Mahadeva, Noel G. McElvaney, David Parr, Eeva Piitulainen, Nicolas Roche, Jan Stolk, Gabriel Thabut, Alice Turner, Claus Vogelmeier, Robert A. Stockley
      European Respiratory Journal 50 (5) 1700610; DOI: 10.1183/13993003.00610-2017 Published 30 November 2017

Original articles

  • COPD

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      A simple algorithm for the identification of clinical COPD phenotypes
      Pierre-Régis Burgel, Jean-Louis Paillasseur, Wim Janssens, Jacques Piquet, Gerben ter Riet, Judith Garcia-Aymerich, Borja Cosio, Per Bakke, Milo A. Puhan, Arnulf Langhammer, Inmaculada Alfageme, Pere Almagro, Julio Ancochea, Bartolome R. Celli, Ciro Casanova, Juan P. de-Torres, Marc Decramer, Andrés Echazarreta, Cristobal Esteban, Rosa Mar Gomez Punter, MeiLan K. Han, Ane Johannessen, Bernhard Kaiser, Bernd Lamprecht, Peter Lange, Linda Leivseth, Jose M. Marin, Francis Martin, Pablo Martinez-Camblor, Marc Miravitlles, Toru Oga, Ana Sofia Ramírez, Don D. Sin, Patricia Sobradillo, Juan J. Soler-Cataluña, Alice M. Turner, Francisco Javier Verdu Rivera, Joan B. Soriano, Nicolas Roche on behalf of Initiatives BPCO, EABPCO, Leuven and 3CIA study groups
      European Respiratory Journal 50 (5) 1701034; DOI: 10.1183/13993003.01034-2017 Published 2 November 2017
    • You have accessRestricted access
      Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD
      Ciro Casanova, Bartolome R. Celli, Juan P. de-Torres, Cristina Martínez-Gonzalez, Borja G. Cosio, Victor Pinto-Plata, Pilar de Lucas-Ramos, Miguel Divo, Antonia Fuster, Germán Peces-Barba, Myriam Calle-Rubio, Ingrid Solanes, Ramón Aguero, Nuria Feu-Collado, Inmaculada Alfageme, Alfredo De Diego, Amparo Romero, Eva Balcells, Antonia Llunell, Juan B. Galdiz, Margarita Marin, Amalia Moreno, Carlos Cabrera, Rafael Golpe, Celia Lacarcel, Joan B. Soriano, José Luis López-Campos, Juan J. Soler-Cataluña, José M. Marin
      European Respiratory Journal 50 (5) 1701162; DOI: 10.1183/13993003.01162-2017 Published 22 November 2017
    • Open Access
      Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study
      Filip Mejza, Louisa Gnatiuc, A. Sonia Buist, William M. Vollmer, Bernd Lamprecht, Daniel O. Obaseki, Pawel Nastalek, Ewa Nizankowska-Mogilnicka, Peter G.J. Burney for the BOLD collaborators
      European Respiratory Journal 50 (5) 1700621; DOI: 10.1183/13993003.00621-2017 Published 22 November 2017
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      Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation
      Ma'en Obeidat, Xuan Li, Stephen Burgess, Guohai Zhou, Nick Fishbane, Nadia N. Hansel, Yohan Bossé, Philippe Joubert, Ke Hao, David C. Nickle, Maarten van den Berge, Wim Timens, Michael H. Cho, Brian D. Hobbs, Kim de Jong, Marike Boezen, Rayjean J. Hung, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H. Beaty, Kathleen C. Barnes, Peter D. Paré, Don D. Sin International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study
      European Respiratory Journal 50 (5) 1700657; DOI: 10.1183/13993003.00657-2017 Published 30 November 2017
    • Open Access
      Metabolic re-patterning in COPD airway smooth muscle cells
      Charalambos Michaeloudes, Chih-Hsi Kuo, Gulam Haji, Donna K. Finch, Andrew J. Halayko, Paul Kirkham, Kian Fan Chung, Ian M. Adcock on behalf of COPDMAP
      European Respiratory Journal 50 (5) 1700202; DOI: 10.1183/13993003.00202-2017 Published 30 November 2017
  • Paediatric pulmonology

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      Temporal stability of multitrigger and episodic viral wheeze in early childhood
      Ben D. Spycher, Cara Cochrane, Raquel Granell, Jonathan A.C. Sterne, Michael Silverman, Eva Pedersen, Erol A. Gaillard, John Henderson, Claudia E. Kuehni
      European Respiratory Journal 50 (5) 1700014; DOI: 10.1183/13993003.00014-2017 Published 2 November 2017
  • Bronchoscopy

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      Endoscopic ultrasound fine-needle aspiration by experienced pulmonologists: a cusum analysis
      Paul Leong, Sheetal Deshpande, Louis B. Irving, Philip G. Bardin, Michael W. Farmer, Barton R. Jennings, Daniel P. Steinfort
      European Respiratory Journal 50 (5) 1701102; DOI: 10.1183/13993003.01102-2017 Published 2 November 2017
  • Cystic fibrosis

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      Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient
      Gwyneth Davies, Janet Stocks, Lena P. Thia, Ah-Fong Hoo, Andrew Bush, Paul Aurora, Lucy Brennan, Simon Lee, Sooky Lum, Philippa Cottam, Joanne Miles, Jane Chudleigh, Jane Kirkby, Ian M. Balfour-Lynn, Siobhán B. Carr, Colin Wallis, Hilary Wyatt, Angie Wade on behalf of the London Cystic Fibrosis Collaboration (LCFC)
      European Respiratory Journal 50 (5) 1700326; DOI: 10.1183/13993003.00326-2017 Published 9 November 2017
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      Elevated lung clearance index in infants with cystic fibrosis shortly after birth
      Elisabeth Kieninger, Sophie Yammine, Insa Korten, Pinelopi Anagnostopoulou, Florian Singer, Urs Frey, Anne Mornand, Maura Zanolari, Isabelle Rochat, Daniel Trachsel, Dominik Mueller-Suter, Alexander Moeller, Carmen Casaulta, Philipp Latzin and the SCILD, and BILD study groups
      European Respiratory Journal 50 (5) 1700580; DOI: 10.1183/13993003.00580-2017 Published 9 November 2017
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      Airway microbiota across age and disease spectrum in cystic fibrosis
      Edith T. Zemanick, Brandie D. Wagner, Charles E. Robertson, Richard C. Ahrens, James F. Chmiel, John P. Clancy, Ronald L. Gibson, William T. Harris, Geoffrey Kurland, Theresa A. Laguna, Susanna A. McColley, Karen McCoy, George Retsch-Bogart, Kurtis T. Sobush, Pamela L. Zeitlin, Mark J. Stevens, Frank J. Accurso, Scott D. Sagel, J. Kirk Harris
      European Respiratory Journal 50 (5) 1700832; DOI: 10.1183/13993003.00832-2017 Published 16 November 2017
  • Lung transplantation

    • You have accessRestricted access
      Donor-specific and -nonspecific HLA antibodies and outcome post lung transplantation
      Stijn E. Verleden, Bart M. Vanaudenaerde, Marie-Paul Emonds, Dirk E. Van Raemdonck, Arne P. Neyrinck, Geert M. Verleden, Robin Vos
      European Respiratory Journal 50 (5) 1701248; DOI: 10.1183/13993003.01248-2017 Published 16 November 2017
  • Sleep

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      The effect of treatment for sleep apnoea on determinants of blood pressure control
      Raquel Casitas, Elisabet Martínez-Cerón, Raúl Galera, Carolina Cubillos-Zapata, María Jesús González-Villalba, Isabel Fernández-Navarro, Begoña Sánchez, Aldara García-Sánchez, Ester Zamarrón, Francisco García-Río
      European Respiratory Journal 50 (5) 1701261; DOI: 10.1183/13993003.01261-2017 Published 16 November 2017
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      Predictors of sleepiness in obstructive sleep apnoea at baseline and after 6 months of continuous positive airway pressure therapy
      Rohit Budhiraja, Clete A. Kushida, Deborah A. Nichols, James K. Walsh, Richard D. Simon, Daniel J. Gottlieb, Stuart F. Quan
      European Respiratory Journal 50 (5) 1700348; DOI: 10.1183/13993003.00348-2017 Published 30 November 2017
  • Asthma

    • Open Access
      Sex-specific impact of asthma during pregnancy on infant gut microbiota
      Petya T. Koleva, Hein M. Tun, Theodore Konya, David S. Guttman, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Malcolm R. Sears, James A. Scott, Anita L. Kozyrskyj for the CHILD Study Investigators
      European Respiratory Journal 50 (5) 1700280; DOI: 10.1183/13993003.00280-2017 Published 22 November 2017
  • Bronchiectasis

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      Correlates and assessment of excess cardiovascular risk in bronchiectasis
      Aarash D. Saleh, Bessie Kwok, Jeremy S. Brown, John R. Hurst
      European Respiratory Journal 50 (5) 1701127; DOI: 10.1183/13993003.01127-2017 Published 22 November 2017
  • Respiratory infections

    • Open Access
      Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study
      Michael Moore, Beth Stuart, Paul Little, Sue Smith, Matthew J. Thompson, Kyle Knox, Anne van den Bruel, Mark Lown, David Mant
      European Respiratory Journal 50 (5) 1700434; DOI: 10.1183/13993003.00434-2017 Published 22 November 2017
  • Breathlessness

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      Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis
      Cindy A. Verberkt, Marieke H.J. van den Beuken-van Everdingen, Jos M.G.A. Schols, Sushma Datla, Carmen D. Dirksen, Miriam J. Johnson, Sander M.J. van Kuijk, Emiel F.M. Wouters, Daisy J.A. Janssen
      European Respiratory Journal 50 (5) 1701153; DOI: 10.1183/13993003.01153-2017 Published 22 November 2017

Review

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    TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications
    Andrea Olschewski, Emma L. Veale, Bence M. Nagy, Chandran Nagaraj, Grazyna Kwapiszewska, Fabrice Antigny, Mélanie Lambert, Marc Humbert, Gábor Czirják, Péter Enyedi, Alistair Mathie
    European Respiratory Journal 50 (5) 1700754; DOI: 10.1183/13993003.00754-2017 Published 9 November 2017

Agora

  • Research letters

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      Un-diagnosing persistent adult asthma
      Brian J. Lipworth, Sunny Jabbal
      European Respiratory Journal 50 (5) 1701433; DOI: 10.1183/13993003.01433-2017 Published 2 November 2017
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      Children under 5 years are at risk for tuberculosis after occasional contact with highly contagious patients: outbreak from a smear-positive healthcare worker
      Roberto Luzzati, Giovanni Battista Migliori, Matteo Zignol, Daniela Maria Cirillo, Massimo Maschio, Riccardo Tominz, Giovanna Ventura, Valentino Patussi, Lia D'Ambrosio, Rosella Centis, Franco Michieletto, Alberto Trovato, Francesco Salton, Marina Busetti, Manuela Di Santolo, Mario Raviglione, Marco Confalonieri
      European Respiratory Journal 50 (5) 1701414; DOI: 10.1183/13993003.01414-2017 Published 2 November 2017
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      Final treatment outcomes of multidrug- and extensively drug-resistant tuberculosis patients in Latvia receiving delamanid-containing regimens
      Liga Kuksa, Linda Barkane, Norbert Hittel, Rajesh Gupta
      European Respiratory Journal 50 (5) 1701105; DOI: 10.1183/13993003.01105-2017 Published 9 November 2017
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      Infertility in an adult cohort with primary ciliary dyskinesia: phenotype–gene association
      Gert Jan Vanaken, Laurence Bassinet, Mieke Boon, Rahma Mani, Isabelle Honoré, Jean-Francois Papon, Harry Cuppens, Martine Jaspers, Natalie Lorent, André Coste, Estelle Escudier, Serge Amselem, Bernard Maitre, Marie Legendre, Sophie Christin-Maitre
      European Respiratory Journal 50 (5) 1700314; DOI: 10.1183/13993003.00314-2017 Published 9 November 2017
    • You have accessRestricted access
      Tuberculosis patients with unknown HIV status in the Netherlands: analysing underreporting and lack of testing
      Maike Arnoldussen, Henrieke Schimmel, Eline Op de Coul, Susan van den Hof, Gerard de Vries
      European Respiratory Journal 50 (5) 1701257; DOI: 10.1183/13993003.01257-2017 Published 16 November 2017
    • You have accessRestricted access
      Proof of concept that most borderline Quantiferon results are true antigen-specific responses
      Jonathan W. Uzorka, Lucia J.M. Kroft, Jaap A. Bakker, Erik W. van Zwet, Erik Huisman, Corine Knetsch-Prins, Cornelis J. van der Zwan, Tom H.M. Ottenhoff, Sandra M. Arend
      European Respiratory Journal 50 (5) 1701630; DOI: 10.1183/13993003.01630-2017 Published 16 November 2017
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      Right ventricular longitudinal strain is diminished in systemic sclerosis compared with idiopathic pulmonary arterial hypertension
      Monica Mukherjee, Valentina Mercurio, Ryan J. Tedford, Ami A. Shah, Steven Hsu, Christopher J. Mullin, Takahiro Sato, Rachel Damico, Todd M. Kolb, Stephen C. Mathai, Paul M. Hassoun
      European Respiratory Journal 50 (5) 1701436; DOI: 10.1183/13993003.01436-2017 Published 22 November 2017
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      Pneumocystosis revealing immunodeficiency secondary to TERC mutation
      Raphael Borie, Caroline Kannengiesser, Flore Sicre de Fontbrune, David Boutboul, Laure Tabeze, Florence Brunet-Possenti, Elodie Lainey, Marie Pierre Debray, Aurélie Cazes, Bruno Crestani
      European Respiratory Journal 50 (5) 1701443; DOI: 10.1183/13993003.01443-2017 Published 22 November 2017
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      Mortality: a neglected outcome in OCS-treated severe asthma
      Arnaud Bourdin, Nicolas Molinari, Isabelle Vachier, Laurie Pahus, Carey Suehs, Pascal Chanez
      European Respiratory Journal 50 (5) 1701486; DOI: 10.1183/13993003.01486-2017 Published 30 November 2017
    • You have accessRestricted access
      Association of wheeze with lung function decline in children with sickle cell disease
      Glenda N. Bendiak, Dimas Mateos-Corral, Anwar Sallam, Eshetu G. Atenafu, Melanie Kirby, Isaac Odame, Peter Bikangaga, Padmaja Subbarao, Hartmut Grasemann
      European Respiratory Journal 50 (5) 1602433; DOI: 10.1183/13993003.02433-2016 Published 30 November 2017
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      The feasibility of a mandibular movement test as a screening tool for polysomnography candidates
      Marie-Caroline Rotty, Jean-Pierre Mallet, Jean-Christian Borel, Carey M. Suehs, Arnaud Bourdin, Nicolas Molinari, Dany Jaffuel
      European Respiratory Journal 50 (5) 1701076; DOI: 10.1183/13993003.01076-2017 Published 30 November 2017
  • Correspondence

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      Recommending prolonged bedaquiline use for the treatment of highly resistant strains of tuberculosis
      Jennifer Furin, Erica Lessem, Vivian Cox
      European Respiratory Journal 50 (5) 1701552; DOI: 10.1183/13993003.01552-2017 Published 9 November 2017
    • You have accessRestricted access
      Bedaquiline: how better to use it
      Jose A. Caminero, Alberto Piubello, Anna Scardigli, Giovanni Battista Migliori
      European Respiratory Journal 50 (5) 1701670; DOI: 10.1183/13993003.01670-2017 Published 9 November 2017
    • You have accessRestricted access
      Restricted magnetic resonance diffusion of lung consolidation is not specific for respiratory exacerbation
      Gaël Dournes, François Laurent
      European Respiratory Journal 50 (5) 1701621; DOI: 10.1183/13993003.01621-2017 Published 16 November 2017
    • You have accessRestricted access
      Are we addressing relevant determinants of smoking cessation?
      Pasquale Caponnetto, Riccardo Polosa
      European Respiratory Journal 50 (5) 1701615; DOI: 10.1183/13993003.01615-2017 Published 22 November 2017
    • You have accessRestricted access
      Neuropsychiatric adverse drug reactions in children initiated on montelukast in real-life practice
      Eduardo Urdaneta
      European Respiratory Journal 50 (5) 1701984; DOI: 10.1183/13993003.01984-2017 Published 22 November 2017
    • You have accessRestricted access
      Neuropsychiatric adverse drug reactions in children initiated on montelukast in real-life practice
      Francine M. Ducharme, Brigitte Bénard
      European Respiratory Journal 50 (5) 1702135; DOI: 10.1183/13993003.02135-2017 Published 22 November 2017

Erratum

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    “Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients.” Myriam Delaunay, Jacques Cadranel, Amélie Lusque, Nicolas Meyer, Valérie Gounant, Denis Moro-Sibilot, Jean-Marie Michot, Judith Raimbourg, Nicolas Girard, Florian Guisier, David Planchard, Anne-Cécile Metivier, Pascale Tomasini, Eric Dansin, Maurice Pérol, Marion Campana, Oliver Gautschi, Martin Früh, Jean-David Fumet, Clarisse Audigier-Valette, Sébastien Couraud, Stéphane Dalle, Marie-Thérèse Leccia, Marion Jaffro, Samia Collot, Grégoire Prévot, Julie Milia and Julien Mazieres. Eur Respir J 2017; 50: 1700050.
    European Respiratory Journal 50 (5) 1750050; DOI: 10.1183/13993003.50050-2017 Published 9 November 2017

Author correction

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    “Neuropsychiatric adverse drug reactions in children initiated on montelukast in real-life practice.” Brigitte Benard, Valérie Bastien, Benjamin Vinet, Roger Yang, Maja Krajinovic and Francine M. Ducharme. Eur Respir J 2017; 50: 1700148.
    European Respiratory Journal 50 (5) 1750148; DOI: 10.1183/13993003.50148-2017 Published 22 November 2017
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