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Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of the katG 315T mutation

Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Thomas Schön, Jan Heyckendorf, Valeriu Crudu
European Respiratory Journal 2017 50: 1701752; DOI: 10.1183/13993003.01752-2017
Dumitru Chesov
1Dept of Pneumology and Allergology, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Chişinău, Republic of Moldova
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  • For correspondence: dumitru.chesov@usmf.md
Nelly Ciobanu
2National TB Reference Laboratory, Phthisiopneumology Institute “Chiril Draganiuc”, Chişinău, Republic of Moldova
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Christoph Lange
3Division of Clinical Infectious Diseases, German Center for Infection Research (DZIF), Research Center Borstel, Borstel, Germany
4International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
5Dept of Medicine, Karolinska Institute, Stockholm, Sweden
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Thomas Schön
6Dept of Infectious Diseases and Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden
7Dept of Clinical and Experimental Medicine, Division of Medical Microbiology, Linköping University, Linköping, Sweden
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Jan Heyckendorf
3Division of Clinical Infectious Diseases, German Center for Infection Research (DZIF), Research Center Borstel, Borstel, Germany
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  • ORCID record for Jan Heyckendorf
Valeriu Crudu
2National TB Reference Laboratory, Phthisiopneumology Institute “Chiril Draganiuc”, Chişinău, Republic of Moldova
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Article Information

vol. 50 no. 4
DOI 
https://doi.org/10.1183/13993003.01752-2017
PubMed 
29025884

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received August 26, 2017
  • Accepted August 29, 2017
  • Published online October 12, 2017.

Copyright & Usage 
Copyright ©ERS 2017

Author Information

  1. Dumitru Chesov1⇑,
  2. Nelly Ciobanu2,
  3. Christoph Lange3,4,5,
  4. Thomas Schön6,7,
  5. Jan Heyckendorf3 and
  6. Valeriu Crudu2
  1. 1Dept of Pneumology and Allergology, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Chişinău, Republic of Moldova
  2. 2National TB Reference Laboratory, Phthisiopneumology Institute “Chiril Draganiuc”, Chişinău, Republic of Moldova
  3. 3Division of Clinical Infectious Diseases, German Center for Infection Research (DZIF), Research Center Borstel, Borstel, Germany
  4. 4International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
  5. 5Dept of Medicine, Karolinska Institute, Stockholm, Sweden
  6. 6Dept of Infectious Diseases and Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden
  7. 7Dept of Clinical and Experimental Medicine, Division of Medical Microbiology, Linköping University, Linköping, Sweden
  1. D. Chesov, Dept of Pneumology and Allergology, State University of Medicine and Pharmacy “Nicolae Testemitanu”, 165, Ştefan cel Mare şi Sfînt Bd., Chişinău, MD-2004, Republic of Moldova. E-mail: dumitru.chesov{at}usmf.md
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Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of the katG 315T mutation
Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Thomas Schön, Jan Heyckendorf, Valeriu Crudu
European Respiratory Journal Oct 2017, 50 (4) 1701752; DOI: 10.1183/13993003.01752-2017

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Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of the katG 315T mutation
Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Thomas Schön, Jan Heyckendorf, Valeriu Crudu
European Respiratory Journal Oct 2017, 50 (4) 1701752; DOI: 10.1183/13993003.01752-2017
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