Extract
Unknown/undiagnosed chronic obstructive pulmonary disease (UCOPD) frequently coexists and negatively impacts in the short- and long-term prognosis of patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) [1]. In the Screening for COPD in Acute coronary syndromes Patients (SCAP) trial [2], we recently showed that COPD is frequently undiagnosed in ccute coronary syndrome (ACS) patients with smoking history. Furthermore, we found that a simple screening procedure including peak expiratory flow measurement and respiratory health status questionnaire (RHSQ) might be administered before hospital discharge to discriminate those at risk of UCOPD. In the SCAP study, it was pre-specified that an ancillary analysis aimed to clarify if UCOPD was related to abnormalities in platelet reactivity and endothelial function.
Abstract
Endothelial dysfunction and increased platelet reactivity in acute coronary syndrome with unknown/undiagnosed COPD http://ow.ly/SVEg30eExbK
Acknowledgements
Author contributions are as follows. R. Pavasini is the guarantor of the content of the manuscript, including the data and analysis. R. Pavasini, G. Campo, F. Vieceli dalla Sega: conception, design, analysis and interpretation of data. R. Pavasini, G. Campo, M. Contoli, A. Papi: data analysis and interpretation. All authors: drafting of the manuscript and revising it critically for important intellectual content. All authors: final approval of the manuscript submitted.
Footnotes
This study is registered at ClinicalTrials.gov (number: NCT02324660).
Conflict of interest: None declared.
- Received June 14, 2017.
- Accepted July 4, 2017.
- Copyright ©ERS 2017
