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Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort

Viktoriya L. Kim, Ngaire A. Coombs, Karl J. Staples, Kristoffer K. Ostridge, Nicholas P. Williams, Stephen A. Wootton, Jeanne-Marie Devaster, Emmanuel Aris, Stuart C. Clarke, Andrew C. Tuck, Simon C. Bourne, Tom M.A. Wilkinson on behalf of the AERIS Study Group
European Respiratory Journal 2017 50: 1700853; DOI: 10.1183/13993003.00853-2017
Viktoriya L. Kim
1NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
3NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
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Ngaire A. Coombs
4Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Karl J. Staples
1NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
5Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK
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  • ORCID record for Karl J. Staples
Kristoffer K. Ostridge
1NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Nicholas P. Williams
1NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Stephen A. Wootton
3NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
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Jeanne-Marie Devaster
6GSK Vaccines, Rixensart, Belgium
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Emmanuel Aris
6GSK Vaccines, Rixensart, Belgium
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Stuart C. Clarke
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
5Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK
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Andrew C. Tuck
7Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK
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Simon C. Bourne
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
8Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, UK
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Tom M.A. Wilkinson
1NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
5Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK
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  • For correspondence: T.Wilkinson@soton.ac.uk
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Article Information

vol. 50 no. 4
DOI 
https://doi.org/10.1183/13993003.00853-2017
PubMed 
29025891

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received April 24, 2017
  • Accepted July 16, 2017
  • Published online October 12, 2017.

Copyright & Usage 
Copyright ©ERS 2017

Author Information

  1. Viktoriya L. Kim1,2,3,
  2. Ngaire A. Coombs4,
  3. Karl J. Staples1,2,5,
  4. Kristoffer K. Ostridge1,2,
  5. Nicholas P. Williams1,2,
  6. Stephen A. Wootton3,
  7. Jeanne-Marie Devaster6,
  8. Emmanuel Aris6,
  9. Stuart C. Clarke2,5,
  10. Andrew C. Tuck7,
  11. Simon C. Bourne2,8 and
  12. Tom M.A. Wilkinson1,2,5⇑
  13. on behalf of the AERIS Study Group9
  1. Tom M.A. Wilkinson, Mailpoint 810, Level F, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: T.Wilkinson{at}soton.ac.uk
    1. 1NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    2. 2Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
    3. 3NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    4. 4Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
    5. 5Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK
    6. 6GSK Vaccines, Rixensart, Belgium
    7. 7Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK
    8. 8Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, UK
    9. 9Members of the AERIS Study Group are listed in the Acknowledgements section
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    Funding

    • GlaxoSmithKline

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    Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
    Viktoriya L. Kim, Ngaire A. Coombs, Karl J. Staples, Kristoffer K. Ostridge, Nicholas P. Williams, Stephen A. Wootton, Jeanne-Marie Devaster, Emmanuel Aris, Stuart C. Clarke, Andrew C. Tuck, Simon C. Bourne, Tom M.A. Wilkinson
    European Respiratory Journal Oct 2017, 50 (4) 1700853; DOI: 10.1183/13993003.00853-2017

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    Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
    Viktoriya L. Kim, Ngaire A. Coombs, Karl J. Staples, Kristoffer K. Ostridge, Nicholas P. Williams, Stephen A. Wootton, Jeanne-Marie Devaster, Emmanuel Aris, Stuart C. Clarke, Andrew C. Tuck, Simon C. Bourne, Tom M.A. Wilkinson
    European Respiratory Journal Oct 2017, 50 (4) 1700853; DOI: 10.1183/13993003.00853-2017
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