European Respiratory Journal: 50 (4)

01 October 2017; volume 50, issue 4

Electronic Resources

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ERJ October Podcast: Lessons from IPF clinical trials over the past 25 years
European Respiratory Journal 50 (4) 17E5004; DOI: 10.1183/13993003.E5004-2017 Published 26 October 2017

Editorial

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A risky political game with climate change
Mehdi Mirsaeidi, Abdy Javadzadeh, Michael Campos

European Respiratory Journal 50 (4) 1701145; DOI: 10.1183/13993003.01145-2017 Published 5 October 2017
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A unique event for the francophone respiratory community
Louis-Philippe Boulet, Elyse Bissonnette, Marc Humbert, Bernard Maître, Bernard Pigearias

European Respiratory Journal 50 (4) 1701479; DOI: 10.1183/13993003.01479-2017 Published 5 October 2017
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Pharmacological treatment optimisation for stable COPD: an endless story?
Maeva Zysman, François Chabot, Bruno Housset, Capucine Morelot Panzini, Philippe Devillier, Nicolas Roche for the Société de Pneumologie de Langue Française

European Respiratory Journal 50 (4) 1701250; DOI: 10.1183/13993003.01250-2017 Published 12 October 2017
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Management of hypertension in obstructive sleep apnoea: predicting blood pressure reduction under continuous positive airway pressure
Renaud Tamisier, Patrick Lévy

European Respiratory Journal 50 (4) 1701822; DOI: 10.1183/13993003.01822-2017 Published 5 October 2017
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Treatment of sarcoidosis-associated pulmonary hypertension: so close, and yet so far
Robert P. Baughman, Oksana A. Shlobin

European Respiratory Journal 50 (4) 1701725; DOI: 10.1183/13993003.01725-2017 Published 19 October 2017
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Mucolytics for COPD: negotiating a slippery slope towards proof of efficacy
Shawn D. Aaron

European Respiratory Journal 50 (4) 1701465; DOI: 10.1183/13993003.01465-2017 Published 12 October 2017
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Morphine to relieve exertional dyspnoea in COPD: myth, dream or reality?
Louis Laviolette, Pierantonio Laveneziana

European Respiratory Journal 50 (4) 1701865; DOI: 10.1183/13993003.01865-2017 Published 19 October 2017
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Next generation of anti-inflammatory therapy for COPD?
Henrik Watz

European Respiratory Journal 50 (4) 1702084; DOI: 10.1183/13993003.02084-2017 Published 26 October 2017
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Are inhaled corticosteroids increasing the “load” for some patients with COPD?
Tom M.A. Wilkinson

European Respiratory Journal 50 (4) 1701848; DOI: 10.1183/13993003.01848-2017 Published 5 October 2017
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Occupational exposure and asthma control
Dick Heederik

European Respiratory Journal 50 (4) 1701951; DOI: 10.1183/13993003.01951-2017 Published 26 October 2017

From the Museum

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The Art of Breathing: Synergy
Tom Kotsimbos, Gary P. Anderson

European Respiratory Journal 50 (4) 1705004; DOI: 10.1183/13993003.05004-2017 Published 26 October 2017

Original articles

Sleep
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  Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring
  Anabel L. Castro-Grattoni, Gerard Torres, Montserrat Martínez-Alonso, Ferran Barbé, Cecilia Turino, Alicia Sánchez-de-la-Torre, Anunciacion Cortijo, Joaquin Duran-Cantolla, Carlos Egea, Gonzalo Cao, Manuel Sánchez-de-la-Torre
  
  European Respiratory Journal 50 (4) 1700651; DOI: 10.1183/13993003.00651-2017 Published 5 October 2017
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  Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea
  Carolina Cubillos-Zapata, Jose Avendaño-Ortiz, Enrique Hernandez-Jimenez, Victor Toledano, Jose Casas-Martin, Anibal Varela-Serrano, Marta Torres, Isaac Almendros, Raquel Casitas, Isabel Fernández-Navarro, Aldara Garcia-Sanchez, Luis A. Aguirre, Ramón Farre, Eduardo López-Collazo, Francisco García-Rio
  
  European Respiratory Journal 50 (4) 1700833; DOI: 10.1183/13993003.00833-2017 Published 19 October 2017
Lung function
- Open Access
  Inter-test reproducibility of the lung clearance index measured by multiple breath washout
  Esther Oude Engberink, Felix Ratjen, Stephanie D. Davis, George Retsch-Bogart, Reshma Amin, Sanja Stanojevic
  
  European Respiratory Journal 50 (4) 1700433; DOI: 10.1183/13993003.00433-2017 Published 5 October 2017
Pulmonary vascular diseases and lung function
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  Combined measurement of carbon monoxide and nitric oxide lung transfer does not improve the identification of pulmonary hypertension in systemic sclerosis
  Bruno Degano, Thibaud Soumagne, Thomas Delaye, Patrick Berger, Thierry Perez, Alicia Guillien, Jean-Luc Pellegrin, David Launay, Nadine Magy-Bertrand, Christian Agard, Kiet Phong Tiev, Thông Hua-Huy, Catherine Tardiff, Véronique Diaz, Arnaud Chambellan, Anh Tuan Dinh-Xuan
  
  European Respiratory Journal 50 (4) 1701008; DOI: 10.1183/13993003.01008-2017 Published 19 October 2017
Pulmonary vascular diseases and sarcoidosis
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  Management and long-term outcomes of sarcoidosis-associated pulmonary hypertension
  Athénaïs Boucly, Vincent Cottin, Hilario Nunes, Xavier Jaïs, Abdelatif Tazi, Grégoire Prévôt, Martine Reynaud-Gaubert, Claire Dromer, Catherine Viacroze, Delphine Horeau-Langlard, Christophe Pison, Emmanuel Bergot, Julie Traclet, Jason Weatherald, Gérald Simonneau, Dominique Valeyre, David Montani, Marc Humbert, Olivier Sitbon, Laurent Savale
  
  European Respiratory Journal 50 (4) 1700465; DOI: 10.1183/13993003.00465-2017 Published 19 October 2017
COPD
- Open Access
  Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study
  Roberto W. Dal Negro, Jadwiga A. Wedzicha, Martin Iversen, Giovanni Fontana, Clive Page, Arrigo F. Cicero, Edoardo Pozzi, Peter M.A. Calverley on behalf of the RESTORE group
  
  European Respiratory Journal 50 (4) 1700711; DOI: 10.1183/13993003.00711-2017 Published 12 October 2017
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  Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
  Viktoriya L. Kim, Ngaire A. Coombs, Karl J. Staples, Kristoffer K. Ostridge, Nicholas P. Williams, Stephen A. Wootton, Jeanne-Marie Devaster, Emmanuel Aris, Stuart C. Clarke, Andrew C. Tuck, Simon C. Bourne, Tom M.A. Wilkinson on behalf of the AERIS Study Group
  
  European Respiratory Journal 50 (4) 1700853; DOI: 10.1183/13993003.00853-2017 Published 12 October 2017
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  Effect of morphine on breathlessness and exercise endurance in advanced COPD: a randomised crossover trial
  Sara J. Abdallah, Courtney Wilkinson-Maitland, Nathalie Saad, Pei Zhi Li, Benjamin M. Smith, Jean Bourbeau, Dennis Jensen
  
  European Respiratory Journal 50 (4) 1701235; DOI: 10.1183/13993003.01235-2017 Published 19 October 2017
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  RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation
  Catherine E. Charron, Paul Russell, Kazuhiro Ito, Simon Lea, Yasuo Kizawa, Charlie Brindley, Dave Singh
  
  European Respiratory Journal 50 (4) 1700188; DOI: 10.1183/13993003.00188-2017 Published 26 October 2017
COPD and respiratory infections
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  Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD
  Marco Contoli, Alessia Pauletti, Maria Rita Rossi, Antonio Spanevello, Paolo Casolari, Andrea Marcellini, Giacomo Forini, Giulia Gnesini, Brunilda Marku, Neil Barnes, Andrea Rizzi, Giacomo Curradi, Gaetano Caramori, Paolo Morelli, Alberto Papi
  
  European Respiratory Journal 50 (4) 1700451; DOI: 10.1183/13993003.00451-2017 Published 5 October 2017
Paediatric pulmonology and asthma
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  A virtual asthma clinic for children: fewer routine outpatient visits, same asthma control
  Lara S. van den Wijngaart, Jolt Roukema, Annemie L.M. Boehmer, Marianne L. Brouwer, Cindy A.C. Hugen, Laetitia E.M. Niers, Arwen J. Sprij, Eleonora R.V.M. Rikkers-Mutsaerts, Bart L. Rottier, A. Rogier T. Donders, Chris M. Verhaak, Mariëlle W. Pijnenburg, Peter J.F.M. Merkus
  
  European Respiratory Journal 50 (4) 1700471; DOI: 10.1183/13993003.00471-2017 Published 5 October 2017
Asthma
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  Characterisation of asthma subgroups associated with circulating YKL-40 levels
  Jose L. Gomez, Xiting Yan, Carole T. Holm, Nicole Grant, Qing Liu, Lauren Cohn, Vera Nezgovorova, Deborah A. Meyers, Eugene R. Bleecker, Gina M. Crisafi, Nizar N. Jarjour, Linda Rogers, Joan Reibman, Geoffrey L. Chupp for the SARP Investigators
  
  European Respiratory Journal 50 (4) 1700800; DOI: 10.1183/13993003.00800-2017 Published 12 October 2017
Asthma and occupational lung disease
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  Occupational exposure to disinfectants and asthma control in US nurses
  Orianne Dumas, Aleta S. Wiley, Catherine Quinot, Raphaëlle Varraso, Jan-Paul Zock, Paul K. Henneberger, Frank E. Speizer, Nicole Le Moual, Carlos A. Camargo Jr
  
  European Respiratory Journal 50 (4) 1700237; DOI: 10.1183/13993003.00237-2017 Published 5 October 2017
Air pollution and asthma
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  Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
  Gayan Bowatte, Bircan Erbas, Caroline J. Lodge, Luke D. Knibbs, Lyle C. Gurrin, Guy B. Marks, Paul S. Thomas, David P. Johns, Graham G. Giles, Jennie Hui, Martine Dennekamp, Jennifer L. Perret, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage
  
  European Respiratory Journal 50 (4) 1602357; DOI: 10.1183/13993003.02357-2016 Published 26 October 2017
Occupational exposure and lung cancer
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  Association between lung cancer somatic mutations and occupational exposure in never-smokers
  Christophe Paris, Pascal Do, Bénédicte Mastroianni, Adrien Dixmier, Patrick Dumont, Eric Pichon, Christos Chouaid, Bruno Coudert, Pascal Foucher, Séverine Fraboulet, Myriam Locatelli-Sanchez, Nathalie Baize, Eric Dansin, Lionel Moreau, Michel Vincent, Pascale Missy, Franck Morin, Denis Moro-Sibilot, Sébastien Couraud for the BioCAST/IFCT-1002 study investigators
  
  European Respiratory Journal 50 (4) 1700716; DOI: 10.1183/13993003.00716-2017 Published 26 October 2017

Reviews

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Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations
Olivier Le Rouzic, Muriel Pichavant, Emilie Frealle, Antoine Guillon, Mustapha Si-Tahar, Philippe Gosset

European Respiratory Journal 50 (4) 1602434; DOI: 10.1183/13993003.02434-2016 Published 12 October 2017
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Idiopathic pulmonary fibrosis: lessons from clinical trials over the past 25 years
Ganesh Raghu

European Respiratory Journal 50 (4) 1701209; DOI: 10.1183/13993003.01209-2017 Published 26 October 2017
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What is precision medicine?
Inke R. König, Oliver Fuchs, Gesine Hansen, Erika von Mutius, Matthias V. Kopp

European Respiratory Journal 50 (4) 1700391; DOI: 10.1183/13993003.00391-2017 Published 19 October 2017

Perspective

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Precision medicine in airway diseases: moving to clinical practice
Alvar Agustí, Mona Bafadhel, Richard Beasley, Elisabeth H. Bel, Rosa Faner, Peter G. Gibson, Renaud Louis, Vanessa M. McDonald, Peter J. Sterk, Mike Thomas, Claus Vogelmeier, Ian D. Pavord on behalf of all participants in the seminar

European Respiratory Journal 50 (4) 1701655; DOI: 10.1183/13993003.01655-2017 Published 19 October 2017

Agora

Research letters
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  Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis
  Sébastien Boutin, Simon Y. Graeber, Mirjam Stahl, A. Susanne Dittrich, Marcus A. Mall, Alexander H. Dalpke
  
  European Respiratory Journal 50 (4) 1701086; DOI: 10.1183/13993003.01086-2017 Published 5 October 2017
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  Endothelial dysfunction and increased platelet reactivity in patients with acute coronary syndrome and undiagnosed COPD: insights into the SCAP trial
  Rita Pavasini, Francesco Vieceli dalla Sega, Francesco Gallo, Giulia Passarini, Alberto Papi, Marco Contoli, Gianluca Campo
  
  European Respiratory Journal 50 (4) 1701183; DOI: 10.1183/13993003.01183-2017 Published 5 October 2017
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  Online asthma management for children is cost-effective
  Lara S. van den Wijngaart, Wietske Kievit, Jolt Roukema, Annemie L.M. Boehmer, Marianne L. Brouwer, Cindy A.C. Hugen, Laetitia E.M. Niers, Arwen J. Sprij, Eleonora R.V.M. Rikkers-Mutsaerts, Bart L. Rottier, Chris M. Verhaak, Mariëlle W. Pijnenburg, Peter J.F.M. Merkus
  
  European Respiratory Journal 50 (4) 1701413; DOI: 10.1183/13993003.01413-2017 Published 5 October 2017
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  The role of ethnicity in the upper airway in a Belgian paediatric population with obstructive sleep apnoea
  Monique Slaats, Wim Vos, Cedric Van Holsbeke, Jan De Backer, Dieter Loterman, Wilfried De Backer, An Boudewyns, Stijn Verhulst
  
  European Respiratory Journal 50 (4) 1701278; DOI: 10.1183/13993003.01278-2017 Published 5 October 2017
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  BRAF and NRAS mutations in circulating Langerhans-like CD1a⁺ cells in a patient with pulmonary Langerhans’ cell histiocytosis
  Li Zhang, Gustavo Pacheco-Rodriguez, Wendy K. Steagall, Jiro Kato, Thomas V. Colby, Mary Haughey, Joel Moss
  
  European Respiratory Journal 50 (4) 1700521; DOI: 10.1183/13993003.00521-2017 Published 12 October 2017
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  Evaluation of tuberculosis screening of immigrants in the Netherlands
  Sarah van de Berg, Connie Erkens, Job van Rest, Susan van den Hof, Margreet Kamphorst, Sytze Keizer, Gerard de Vries
  
  European Respiratory Journal 50 (4) 1700977; DOI: 10.1183/13993003.00977-2017 Published 12 October 2017
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  Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study
  Yi-Qian Sun, Yue Chen, Arnulf Langhammer, Frank Skorpen, Chunsen Wu, Xiao-Mei Mai
  
  European Respiratory Journal 50 (4) 1700824; DOI: 10.1183/13993003.00824-2017 Published 12 October 2017
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  Prospective study of body mass index and risk of sarcoidosis in US women
  Orianne Dumas, Krislyn M. Boggs, Yvette C. Cozier, Meir J. Stampfer, Carlos A. Camargo Jr
  
  European Respiratory Journal 50 (4) 1701397; DOI: 10.1183/13993003.01397-2017 Published 19 October 2017
- Open Access
  Effect of pirfenidone on cough in patients with idiopathic pulmonary fibrosis
  Mirjam J.G. van Manen, Surinder S. Birring, Carlo Vancheri, Virginia Vindigni, Elisabetta Renzoni, Anne-Marie Russell, Monique Wapenaar, Vincent Cottin, Marlies S. Wijsenbeek
  
  European Respiratory Journal 50 (4) 1701157; DOI: 10.1183/13993003.01157-2017 Published 19 October 2017
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  Do admission glucose levels aid in predicting mortality associated with community-acquired pneumonia?
  Douwe F. Postma, Cornelis H. van Werkhoven, Darren P.R. Troeman, Sanjay U.C. Sankatsing, Jan Jelrik Oosterheert, Marc J.M. Bonten
  
  European Respiratory Journal 50 (4) 1700307; DOI: 10.1183/13993003.00307-2017 Published 19 October 2017
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  Tuberculosis screening in asylum seekers in Germany, 2015: characteristics of cases and yield
  Lena Fiebig, Barbara Hauer, Marta Andrés, Walter Haas
  
  European Respiratory Journal 50 (4) 1602550; DOI: 10.1183/13993003.02550-2016 Published 26 October 2017
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  Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis
  Chiori Kodama, Berit Lange, Ioana D. Olaru, Palwasha Khan, Marc Lipman, James A. Seddon, Derek Sloan, Louis Grandjean, Rashida Abbas Ferrand, Katharina Kranzer
  
  European Respiratory Journal 50 (4) 1701044; DOI: 10.1183/13993003.01044-2017 Published 26 October 2017
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  Frequency and significance of indeterminate and borderline Quantiferon Gold TB IGRA results
  James Brown, Kartik Kumar, Jacob Reading, Jennifer Harvey, Saraswathi Murthy, Santino Capocci, Susan Hopkins, Suranjith Seneviratne, Ian Cropley, Marc Lipman
  
  European Respiratory Journal 50 (4) 1701267; DOI: 10.1183/13993003.01267-2017 Published 26 October 2017
Correspondence
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  Crowdfunding for respiratory research: a new frontier for patient and public engagement?
  Darrin P. Wiebe, J. Mark FitzGerald
  
  European Respiratory Journal 50 (4) 1701333; DOI: 10.1183/13993003.01333-2017 Published 5 October 2017
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  High-dose isoniazid in the shorter-course multidrug-resistant tuberculosis regimen in the Republic of Moldova
  Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Jan Heyckendorf, Valeriu Crudu
  
  European Respiratory Journal 50 (4) 1701340; DOI: 10.1183/13993003.01340-2017 Published 12 October 2017
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  A katG 315 mutation alone should not lead to exclusion of isoniazid in treatment of multidrug-resistant tuberculosis
  Einar Heldal
  
  European Respiratory Journal 50 (4) 1701696; DOI: 10.1183/13993003.01696-2017 Published 12 October 2017
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  Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of the katG 315T mutation
  Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Thomas Schön, Jan Heyckendorf, Valeriu Crudu
  
  European Respiratory Journal 50 (4) 1701752; DOI: 10.1183/13993003.01752-2017 Published 12 October 2017
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  Xpert MTB/RIF Ultra: the long-awaited game changer for tuberculous meningitis?
  Jerome H. Chin
  
  European Respiratory Journal 50 (4) 1701201; DOI: 10.1183/13993003.01201-2017 Published 19 October 2017
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  Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how “large” your diagnostic criteria are
  Giulio Rossi, Lucia Longo, Fausto Barbieri, Federica Bertolini, Paolo Spagnolo
  
  European Respiratory Journal 50 (4) 1701292; DOI: 10.1183/13993003.01292-2017 Published 26 October 2017
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  Why we should improve current practice of diagnosing and treating pulmonary large cell neuroendocrine carcinomas in patients with advanced disease
  Jules Derks, Robert Jan van Suylen, Erik Thunnissen, Michael den Bakker, Harry Groen, Egbert Smit, Ronald Damhuis, Esther van den Broek, Ernst-Jan Speel, Anne-Marie C. Dingemans
  
  European Respiratory Journal 50 (4) 1701658; DOI: 10.1183/13993003.01658-2017 Published 26 October 2017

Author Correction

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“Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.” Geoffrey Chupp, Michel Laviolette, Lauren Cohn, Charlene McEvoy, Sandeep Bansal, Adrian Shifren, Sumita Khatri, G. Mark Grubb, Edmund McMullen, Racho Strauven and Joel N. Kline. Eur Respir J 2017; 50: 1700017.
European Respiratory Journal 50 (4) 1750017; DOI: 10.1183/13993003.50017-2017 Published 12 October 2017

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Table of Contents

Electronic Resources

Editorial

From the Museum

Original articles

Sleep

Lung function

Pulmonary vascular diseases and lung function

Pulmonary vascular diseases and sarcoidosis

COPD

COPD and respiratory infections

Paediatric pulmonology and asthma

Asthma

Asthma and occupational lung disease

Air pollution and asthma

Occupational exposure and lung cancer

Reviews

Perspective

Agora

Research letters

Correspondence

Author Correction

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