The shorter multidrug-resistant tuberculosis treatment regimen in Singapore: are patients from South-East Asia eligible?

Cynthia B.E. Chee; Kyi-Win KhinMar; Li-H. Sng; Roland Jureen; Jeffery Cutter; Vernon J.M. Lee; Yee-Tang Wang

doi:10.1183/13993003.00753-2017

Tables

TABLE 1

Number and percentage of cases resistant to each of the six individual drugs in the shorter World Health Organization regimen, resistant to at least one of the six drugs and resistant to at least one of the five drugs excluding ethambutol, classified according to country of origin

Drug	Bangladesh (n=4)	China (n=37)	India (n=7)	Indonesia (n=76)	Myanmar (n=56)	Philippines (n=18)	Vietnam (n=15)	Singapore/Malaysia (n=54)	Total (n=267)
Ethambutol
Tested	4 (100)	37 (100)	7 (100)	76 (100)	56 (100)	18 (100)	15 (100)	54 (100)	267 (100)
Resistant	3 (75.0)	13 (35.1)	5 (71.4)	38 (50.0)	34 (60.7)	2 (11.1)	6 (40)	15 (27.8)	116 (43.4)
Pyrazinamide
Tested	2 (50.0)	23 (62.2)	3 (42.9)	32 (42.1)	40 (71.4)	10 (55.6)	11 (73.3)	44 (81.5)	165 (61.8)
Resistant	0 (0.0)	13 (56.5)	2 (66.7)	20 (62.5)	24 (60.0)	3 (30.0)	7 (63.6)	3 (6.8)	72 (43.6)
Ethionamide
Tested	4 (100)	37 (100)	7 (100)	75 (98.7)	56 (100)	18 (100)	15 (100)	54 (100)	266 (99.6)
Resistant	0 (0.0)	14 (37.8)	0 (0.0)	17 (22.7)	8 (14.3)	8 (44.4)	2 (13.3)	26 (48.1)	75 (28.2)
Kanamycin
Tested	4 (100)	37 (100)	7 (100)	75 (98.7)	56 (100)	18 (100)	15 (100)	54 (100)	266 (99.6)
Resistant	1 (25.0)	1 (2.7)	0 (0.0)	7 (9.3)	0 (0.0)	0 (0.0)	2 (13.3)	0 (0.0)	11 (4.1)
Ofloxacin
Tested	3 (75.0)	37 (100)	7 (100)	72 (94.7)	56 (100)	18 (100)	15 (100)	53 (98.1)	261 (97.8)
Resistant	0 (0.0)	3 (8.1)	0 (0.0)	21 (29.2)	7 (12.5)	0 (0.0)	3 (20.0)	1 (1.9)	35 (13.4)
Clofazimine
Tested	2 (50.0)	15 (40.5)	2 (28.6)	18 (23.7)	23 (40.7)	7 (38.9)	8 (53.3)	30 (55.6)	105 (39.3)
Resistant	0 (0.0)	0 (0.0)	0 (0.0)	3 (16.7)	1 (4.3)	0 (0.0)	0 (0.0)	0 (0.0)	4 (3.8)
Resistant to at least one of the above six drugs	3 (75.0)	23 (62.2)	6 (85.7)	57 (75.0)	40 (71.4)	10 (55.6)	12 (80.0)	39 (72.2)	190 (71.2)
Resistant to at least one of the above five drugs excluding ethambutol	1 (25.0)	20 (54.1)	2 (28.6)	44 (57.9)	30 (53.6)	9 (50.0)	8 (53.3)	28 (51.9)	142 (53.2)