Extract
Dyspnoea is the aversive cardinal symptom in various prevalent conditions such as respiratory, cardiovascular and neuromuscular diseases and is associated with great individual and socioeconomic burden [1]. Over the past years, several physiological and also psychological factors have been demonstrated to affect the perception of dyspnoea [1, 2]. For example, high levels of anxiety in adulthood were associated with increased dyspnoea perception in patients with asthma or chronic obstructive pulmonary disease (COPD), but also in healthy controls [2]. Moreover, adverse, separation-related experiences in childhood were linked to the subsequent development of increased anxiety and dyspnoea [3]. However, the effects of adverse experiences in early, prenatal life on dyspnoea perception remain widely unknown, although prenatal exposure to maternal stress and anxiety has convincingly been related to the development of other health and behavioural problems later in life, including impairments of the respiratory control system and high anxiety levels [4–9]. Therefore, this study investigated the relationship between prenatal exposure to maternal stress and the perception of dyspnoea in adulthood 28 years later.
Abstract
Prenatal exposure to maternal stress is associated with increased perception of dyspnoea in adulthood 28 years later http://ow.ly/M6EH30d1NEQ
Footnotes
Support statement: This study was partly supported by a grant from the European Commission Seventh Framework Programme (FP7–HEALTH.2011.2.2.2-2 BRAINAGE, Grant agreement no: 279281) to B.R.H. Van den Bergh and an infrastructure grant from the Herculesstichting, Belgium (AKUL/13/07) to A. von Leupoldt. A. von Leupoldt is supported by the “Asthenes” long-term structural funding Methusalem grant (# METH/15/011) by the Flemish Government, Belgium. Funding information for this article has been deposited with the Crossref Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received March 27, 2017.
- Accepted May 20, 2017.
- Copyright ©ERS 2017