Extract
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) remain significant global health challenges, with an annual incidence of approximately 480 000 and 46 000 cases, respectively [1]. Treatment outcomes in MDR-TB patients remain poor overall (52% success) and outcomes in XDR-TB patients are even more dismal (28% success) [1–3]. To improve these outcomes, new drugs are needed [4]. Delamanid, a nitroimidazooxazole agent that has been included in the guidelines for MDR-TB treatment by the World Health Organization (WHO), has been shown to improve two-month sputum culture conversion (SCC) and long-term treatment outcomes, when added to an optimised background regimen (OBR) in MDR-TB patients [5–7]. As part of a global access initiative, Otsuka Pharmaceutical Co., Ltd. in coordination with the European Respiratory Society (ERS)/WHO TB Consilium, and Médecins Sans Frontières/Partners in Health (MSF-PIH) established its first Compassionate Use (CU) programme in February 2014 to provide patients with very limited treatment options access to delamanid. We present here early safety and efficacy outcomes of patients enrolled in this effort.
Abstract
Early data from the CU programme show delamanid may be effective in MDR/XDR-TB with few treatment options http://ow.ly/tA6Y30cs2Yg
Acknowledgements
We would like to thank Clotilde Picard and Lusine Breitscheidel (Otsuka Novel Products GmbH, Munich, Germany) for their assistance with data collection, as well as Zuzanna Huebschmann (Otsuka Novel Products GmbH) for her critical review of the manuscript.
Footnotes
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received February 13, 2017.
- Accepted April 24, 2017.
- Copyright ©ERS 2017
This ERJ Open article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.