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Factors associated with bronchial hyperresponsiveness in Australian adults and children

JK Peat, CM Salome, AJ Woolcock
European Respiratory Journal 1992 5: 921-929; DOI: 10.1183/09031936.93.05080921
JK Peat
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CM Salome
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AJ Woolcock
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Abstract

To accurately assess putative risk factors for bronchial hyperresponsiveness (BHR), we have used multivariate models to analyse data from 4,366 children living in four regions and from 878 adults. A standard protocol was used to measure bronchial responsiveness to histamine. The prevalence of BHR was high at 7-9 yrs (16-18%), decreased significantly at 11-14 yrs (7-8%), and then increased in adults (12-14%). Atopy was the most important risk factor for BHR at all ages. In children, parental asthma, early respiratory illness and being born in Australia also had a significant influence, and eating fish more than once a week had a protective effect. No effect of parental smoking, gender or race was found. In adults, BHR was associated with being female and with smoking history. It appears that many factors have a significant influence on the presence of BHR, with environmental factors, particularly atopy, birthplace and diet, being the most important.

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Factors associated with bronchial hyperresponsiveness in Australian adults and children
JK Peat, CM Salome, AJ Woolcock
European Respiratory Journal Sep 1992, 5 (8) 921-929; DOI: 10.1183/09031936.93.05080921

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Factors associated with bronchial hyperresponsiveness in Australian adults and children
JK Peat, CM Salome, AJ Woolcock
European Respiratory Journal Sep 1992, 5 (8) 921-929; DOI: 10.1183/09031936.93.05080921
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