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Effects of celiprolol, a cardioselective beta-blocker, on respiratory function in asthmatic patients

JC Pujet, C Dubreuil, B Fleury, O Provendier, ML Abella
European Respiratory Journal 1992 5: 196-200; DOI:
JC Pujet
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C Dubreuil
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B Fleury
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O Provendier
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ML Abella
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Abstract

The aim of this study was to compare the pulmonary effects of a single dose of celiprolol 400 mg, versus bisoprolol 20 mg and the combination of celiprolol 400 mg plus propranolol 40 mg versus placebo plus propranolol 40 mg. We conducted a double-blind randomized cross-over study in 10 stable asthmatic patients (mean age +/- SD 31 +/- 7 yrs) with forced expiratory volume in one second (FEV1): 2.5 +/- 0.7 l. A three-day washout period preceded each treatment period. Measurements of respiratory function were done before treatment and after 90, 120 and 180 min. There was a significant increase of FEV1 (+12%) and forced vital capacity (FVC) (+8%) after celiprolol (p less than 0.05) and a decrease of FEV1 (-9%) after propranolol. Concerning the combination, celiprolol inhibits the bronchoconstrictor effects of propranolol. We conclude that celiprolol has bronchosparing properties in asthmatic patients, and even improves some of the ventilatory parameters.

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Effects of celiprolol, a cardioselective beta-blocker, on respiratory function in asthmatic patients
JC Pujet, C Dubreuil, B Fleury, O Provendier, ML Abella
European Respiratory Journal Feb 1992, 5 (2) 196-200;

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Effects of celiprolol, a cardioselective beta-blocker, on respiratory function in asthmatic patients
JC Pujet, C Dubreuil, B Fleury, O Provendier, ML Abella
European Respiratory Journal Feb 1992, 5 (2) 196-200;
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