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LSC Abstract – The AsthmaMap: Towards a community-driven reconstruction of asthma-relevant pathways and networks

Alexander Mazein, Bertrand De Meulder, Diane Lefaudeux, Richard G. Knowles, Craig Wheelock, Sven-Erik Dahlen, Fan Chung, Ian Adcock, Peter Openshaw, Graham Roberts, Ratko Djukanovic, Piotr Gawron, Marek Ostaszewski, Vasundra Touré, Micha Kuzma, Mansoor Saqi, Johann Pellet, Reinhard Schneider, Rudi Balling, Peter Sterk, Charles Auffray, The U-BIOPRED Study Group, The eTRIKS Working Group
European Respiratory Journal 2016 48: PP204; DOI: 10.1183/13993003.congress-2016.PP204
Alexander Mazein
1CNRS-EISBM, Lyon, France
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Bertrand De Meulder
1CNRS-EISBM, Lyon, France
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Diane Lefaudeux
1CNRS-EISBM, Lyon, France
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Richard G. Knowles
2Knowles Consulting, Stevenage, United Kingdom
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Craig Wheelock
3Karolinska Institutet, Stockholm, Sweden
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Sven-Erik Dahlen
3Karolinska Institutet, Stockholm, Sweden
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Fan Chung
4Imperial College London, London, United Kingdom
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Ian Adcock
4Imperial College London, London, United Kingdom
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Peter Openshaw
4Imperial College London, London, United Kingdom
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Graham Roberts
5Imperial College London, London, United Kingdom
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Ratko Djukanovic
5Imperial College London, London, United Kingdom
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Piotr Gawron
6Luxembourg Centre for Systems Biomedicine, Luxembourg, Luxembourg
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Marek Ostaszewski
6Luxembourg Centre for Systems Biomedicine, Luxembourg, Luxembourg
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Vasundra Touré
1CNRS-EISBM, Lyon, France
7Université Paris-Sud, Orsay, France
8Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany
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Micha Kuzma
1CNRS-EISBM, Lyon, France
9Poznan University of Technology, Poznan, Poland
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Mansoor Saqi
1CNRS-EISBM, Lyon, France
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Johann Pellet
1CNRS-EISBM, Lyon, France
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Reinhard Schneider
6Luxembourg Centre for Systems Biomedicine, Luxembourg, Luxembourg
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Rudi Balling
6Luxembourg Centre for Systems Biomedicine, Luxembourg, Luxembourg
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Peter Sterk
10Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
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Charles Auffray
1CNRS-EISBM, Lyon, France
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1CNRS-EISBM, Lyon, France
1CNRS-EISBM, Lyon, France
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Abstract

Background: Recent advances in systems medicine allow detailed reconstruction of molecular interactions in particular diseases e.g. Parkinson's disease map (Fujita et al., Molecular Neurobiology, 2013) and Atlas of Cancer Signalling Networks (Kuperstein et al., Oncogenesis, 2015).

Objectives: 1. Integration of current knowledge on asthma into a network of molecular interactions. 2. Explore applications for functional analysis and interpretation of multi-omics data.

Methods: The standard Systems Biology Graphical Notation (SBGN, www.sbgn.org) is used for literature-based network reconstruction, with ensuing review by domain experts to ensure high-quality knowledge representation.

Results: AsthmaMap is a collection of interconnected asthma-relevant pathways including 22 cell types, > 50 receptors and their signaling pathways and > 1,000 proteins and metabolites associated with asthma pathogenesis. We demonstrate its application for adequate description of disease mechanisms and for result interpretation of disease phenotyping based on clinical and multi-omics data from UBIOPRED severe asthma cohorts, as well as its potential application as a knowledge resource and teaching aid.

Conclusion: AsthmaMap is the first knowledge base that collects and integrates known molecular processes involved in asthma. While being complementary to other pathway analysis solutions, AsthmaMap enables multiple 'omics data visualisation and their interpretation in the asthma-specific context, thus supporting the process of systems medicine.

Acknowledgements: Funded by the Innovative Medicines Initiative (U-BIOPRED n°115010, eTRIKS n°115446).

  • Copyright ©the authors 2016
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LSC Abstract – The AsthmaMap: Towards a community-driven reconstruction of asthma-relevant pathways and networks
Alexander Mazein, Bertrand De Meulder, Diane Lefaudeux, Richard G. Knowles, Craig Wheelock, Sven-Erik Dahlen, Fan Chung, Ian Adcock, Peter Openshaw, Graham Roberts, Ratko Djukanovic, Piotr Gawron, Marek Ostaszewski, Vasundra Touré, Micha Kuzma, Mansoor Saqi, Johann Pellet, Reinhard Schneider, Rudi Balling, Peter Sterk, Charles Auffray, The U-BIOPRED Study Group, The eTRIKS Working Group
European Respiratory Journal Sep 2016, 48 (suppl 60) PP204; DOI: 10.1183/13993003.congress-2016.PP204

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LSC Abstract – The AsthmaMap: Towards a community-driven reconstruction of asthma-relevant pathways and networks
Alexander Mazein, Bertrand De Meulder, Diane Lefaudeux, Richard G. Knowles, Craig Wheelock, Sven-Erik Dahlen, Fan Chung, Ian Adcock, Peter Openshaw, Graham Roberts, Ratko Djukanovic, Piotr Gawron, Marek Ostaszewski, Vasundra Touré, Micha Kuzma, Mansoor Saqi, Johann Pellet, Reinhard Schneider, Rudi Balling, Peter Sterk, Charles Auffray, The U-BIOPRED Study Group, The eTRIKS Working Group
European Respiratory Journal Sep 2016, 48 (suppl 60) PP204; DOI: 10.1183/13993003.congress-2016.PP204
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