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LATE-BREAKING ABSTRACT: Antioxidant supplementation in chronic obstructive pulmonary disease (COPD): A relevant way to optimize pulmonary rehabilitation effects

Jonathan Maury, Fares Gouzi, Nelly Héraud, Philippe De Rigal, Nicolas Molinari, Joël Pincemail, Dalila Laoudj-Chenivesse, François Bughin, Magali Poulain, Marine Blaquière, Jacques Mercier, Christian Préfaut, Pascal Pomiès, Maurice Hayot
European Respiratory Journal 2016 48: PA714; DOI: 10.1183/13993003.congress-2016.PA714
Jonathan Maury
1Pulmonary Rehabilitation Center “La Solane”, 5-Santé Group, Osséja, France
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Fares Gouzi
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Nelly Héraud
3Pulmonary Rehabilitation Center “La Vallonie”, 5-Santé Group, Lodève, France
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Philippe De Rigal
1Pulmonary Rehabilitation Center “La Solane”, 5-Santé Group, Osséja, France
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Nicolas Molinari
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Joël Pincemail
4Department of Cardiovascular Surgery and CREDEC, University of Liège, CHU Sart Tilman, Liège, Belgium
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Dalila Laoudj-Chenivesse
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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François Bughin
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Magali Poulain
1Pulmonary Rehabilitation Center “La Solane”, 5-Santé Group, Osséja, France
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Marine Blaquière
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Jacques Mercier
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Christian Préfaut
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Pascal Pomiès
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Maurice Hayot
2PhyMedExp, INSERM U1046 - CNRS UMR9214, INSERM - CNRS - University Montpellier - CHU Montpellier, Montpellier, France
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Abstract

In COPD patients oxidative stress (OS) is a limiting factor of exercise training effects on muscle impairment during pulmonary rehabilitation (PR). Antioxidant supplementation used during PR appeared inappropriate to cope with COPD-related antioxidant deficits. We therefore investigated whether exercise training PR, combined with non-pharmacological antioxidant supplementation (vitamins C and E, zinc, selenium), would have beneficial effects on muscle impairment and exercise capacity.

58 stable COPD patients (61 years; FEV1: 59%predicted) referred for a 4-week PR program, were recruited in a double-blind randomized, placebo-controlled clinical trial. Primary outcome was change in quadriceps endurance (Qend). Secondary outcomes were: quadriceps maximal voluntary contraction (QMVC), exercise capacity (maximal oxygen uptake (Vo2sl), systemic OS markers and muscle fiber cross sectional area (CSA).

Qend was significantly increased in both COPD patient groups. QMVC and VO2sl were improved (+9 and +16%, respectively) exclusively in “PR+antioxidant” group (p=0.01 and p<0.05). The “PR+antioxidant” group showed a significant increase in vitamin E and selenium compared to “PR+placebo” group (p=0.05 and p<0.001, respectively) without differences in vitamin C and lipid peroxidation. Muscle fiber CSA was significantly increased in “PR+antioxidant” group compared to “PR+placebo” group (+17% vs -6% respectively, p<0.05).

In conclusion, this study showed that antioxidant supplementation combining vitamin C, E, zinc and selenium, improves the PR effects on QMVC, Vo2sl and muscle fiber CSA by enhancing antioxidant capacity of COPD patients.

  • COPD - management
  • Quality of life
  • Sepsis
  • Copyright ©the authors 2016
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LATE-BREAKING ABSTRACT: Antioxidant supplementation in chronic obstructive pulmonary disease (COPD): A relevant way to optimize pulmonary rehabilitation effects
Jonathan Maury, Fares Gouzi, Nelly Héraud, Philippe De Rigal, Nicolas Molinari, Joël Pincemail, Dalila Laoudj-Chenivesse, François Bughin, Magali Poulain, Marine Blaquière, Jacques Mercier, Christian Préfaut, Pascal Pomiès, Maurice Hayot
European Respiratory Journal Sep 2016, 48 (suppl 60) PA714; DOI: 10.1183/13993003.congress-2016.PA714

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LATE-BREAKING ABSTRACT: Antioxidant supplementation in chronic obstructive pulmonary disease (COPD): A relevant way to optimize pulmonary rehabilitation effects
Jonathan Maury, Fares Gouzi, Nelly Héraud, Philippe De Rigal, Nicolas Molinari, Joël Pincemail, Dalila Laoudj-Chenivesse, François Bughin, Magali Poulain, Marine Blaquière, Jacques Mercier, Christian Préfaut, Pascal Pomiès, Maurice Hayot
European Respiratory Journal Sep 2016, 48 (suppl 60) PA714; DOI: 10.1183/13993003.congress-2016.PA714
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  • Developing integrated symptom-based diagnostic pathways: how do adults with breathlessness currently present to secondary care?
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