Abstract
Introduction or background: E-Selectin (ES) is one of the adhesion molecules expressed on the vascular endothelial cells. We previously demonstrated that ES predicts the occurrence of acute lung injury in the pneumonic patients.
Aims and objectives: To assess whether ES predicts the outcome of the patients with inflammatory lung diseases (IDs).
Methods: We analyzed serum levels of ES in the 118 patients who were admitted to our hospital due to IDs including interstitial pneumonia (n=41), and lower respiratory tract infection (n=69), and pneumothorax, as non-inflammatory disease control (n=8), from January 2013 to December 2013, retrospectively. One hundred eleven patients were alive during hospital stay, and seven patents were died due to respiratory failure (n=7).
Results: Subjects' mean age was 71.8 years (78 men and 40 women). Mean hospital stay was 18.8 days. ES levels in the IDs tended to be higher compared to control group (P =0.09). Among the patients with the IDs, circulating levels of ES were significantly higher in patients who were died than those who were alive (alive: 5241 ± 389 pg/mL, died: 11012 ± 1486 pg/mL, P <0.05).
Conclusions: ES may be a predictive factor for outcome of patients with IDs.
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